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The antitumor activity of the fungicide ciclopirox 원문보기

International journal of cancer: Journal international du cancer, v.127 no.10, 2010년, pp.2467 - 2477  

Zhou, Hongyu (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Shen, Tao (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Luo, Yan (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Liu, Lei (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Chen, Wenxing (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Xu, Baoshan (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Han, Xiuzhen (Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Pang, Jia (Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA) ,  Rivera, Chantal A. (Department of Molecular and Cellular Physiology, Louisian) ,  Huang, Shile

Abstract AI-Helper 아이콘AI-Helper

Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell cu...

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