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Abstract ▼ AI-Helper

Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been uses as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G. elata BI. has not been scientifically investigated. Therefore, the pres...

Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been uses as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G. elata BI. has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic properly and interaction with benzodiazepine receptor of G. elata BI. The putative anxiolytic activity of ethanol extract of G. elata BI. was performed in mice using an elevated plus maze paradigm. Chronic oral administration of G. elata BI. showed anxiolytic action in mice. It was suggested that regulation of GABAergic neurotransmission may be important in the action of G. elata BI. The interaction of G. elata BI. with benzodiazepine receptor was investigated using rat cortices. Ethanol extract of G. elata inhibited the binding of ［³H］ Ro15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor. The inhibition of ［³H］ Ro15-1788 binding by G. elata BI. appeared to be competitive. Further, GABA significantly enhanced the potency of this extract in inhibiting ［³H］ flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic properly of G. elata BI.

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