다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Microvascular research, v.106, 2016년, pp.128 - 136
da Guarda, C.C. , Santiago, R.P. , Pitanga, T.N. , Santana, S.S. , Zanette, D.L. , Borges, V.M. , Goncalves, M.S.
AI-Helper
The sickle cell disease (SCD) is a hemolytic genetic anemia characterized by free heme and hemoglobin release into intravascular spaces, with endothelial activation. Heme is a proinflammatory molecule able to directly activate vascular endothelium, thus, endothelial dysfunction and vascular disease ...
Blood Belcher 96 7 2451 2000 10.1182/blood.V96.7.2451 Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion
Blood Belcher 123 3 377 2014 10.1182/blood-2013-04-495887 Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
JAMA Bjelakovic 8 297 842 2007 10.1001/jama.297.8.842 Mortality in randomized trials of antioxidant supplements for primary and secondary prevention systematic review and meta-analysis
Kidney Int. Blanco-Colio 63 1 12 2003 10.1046/j.1523-1755.2003.00744.x Anti-inflammatory and immunomodulatory effects of statins
Blood Brittain 115 10 2014 2010 10.1182/blood-2009-04-217950 Placenta growth factor in sickle cell disease: association with hemolysis and inflammation
Free Radic. Biol. Med. Bryan 43 5 645 2007 10.1016/j.freeradbiomed.2007.04.026 Methods to detect nitric oxide and its metabolites in biological samples
Chem. Biol. Interact. Cai 137 1 75 2001 10.1016/S0009-2797(01)00210-1 Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper
Haematologica Canalli 96 4 526 2011 10.3324/haematol.2010.032912 Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin
Biochemistry Carcamo 41 43 12995 2002 10.1021/bi0263210 Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation
Carvalho MOS 2014 Doença falciforme: avaliação de biomarcadores relacionados ao perfil lipídico e disfunção endotelial
Blood Charache 79 10 2555 1992 10.1182/blood.V79.10.2555.2555 Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia
Antioxid. Redox Signal. Clement 3 1 157 2001 10.1089/152308601750100687 The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide
Nitric Oxide Cokic 16 3 371 2007 10.1016/j.niox.2007.01.001 Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity
Lancet Collina 360 9326 7 2002 10.1016/S0140-6736(02)09327-3 MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo controlled trial
Haematologica Covas 89 3 273 2004 Effects of hydroxyurea on the membrane of erythrocytes and platelets in sickle cell anemia
Free Radic. Biol. Med. Dhar-Mascareno 38 10 1311 2005 10.1016/j.freeradbiomed.2005.01.017 Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C
Arterioscler. Thromb. Vasc. Biol. Dichtl 23 1 58 2003 10.1161/01.ATV.0000043456.48735.20 HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
Free Radic. Res. Duarte 39 7 671 2005 10.1080/10715760500104025 Review: when is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C
Eur J Pharmacol El-Azab 690 1-3 31 2012 10.1016/j.ejphar.2012.06.002 Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: effects on capillary density, angiogenesis markers, and oxidative stress
Biochim. Biophys. Acta Feng 1814 12 1997 2011 10.1016/j.bbapap.2011.08.004 Intraprotein electron transfer between the FMN and heme domains in endothelial nitric oxide synthase holoenzyme
J. Biol. Chem. Figueiredo 282 28 20221 2007 10.1074/jbc.M610737200 Characterization of heme as activator of Toll-like receptor 4
Proc. Natl. Acad. Sci. U. S. A. Frei 86 16 6377 1989 10.1073/pnas.86.16.6377 Ascorbate is an outstanding antioxidant in human blood plasma
Blood Graca-Souza 99 11 4160 2002 10.1182/blood.V99.11.4160 Neutrophil activation by heme: implications for inflammatory processes
Microcirculation Hebbel 11 2 129 2004 10.1080/mic.11.2.129.151 The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy
J. Biol. Chem. Heller 274 12 8254 1999 10.1074/jbc.274.12.8254 l-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells
Br. J. Haematol. Hoppe 153 5 655 2011 10.1111/j.1365-2141.2010.08480.x A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction
Blood Jeney 100 3 879 2002 10.1182/blood.V100.3.879 Pro-oxidant and cytotoxic effects of circulating heme
Annu. Rev. Biochem. Kaelin 74 115 2005 10.1146/annurev.biochem.74.082803.133142 Proline hydroxylation and gene expression
Ind. J. Endocrinol. Metabol. Kavalipati 19 5 554 2015 10.4103/2230-8210.163106 Pleiotropic effects of statins
Med. Hypotheses Kovacic 76 1 24 2011 10.1016/j.mehy.2010.08.023 Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications
Toxicol. Lett. Kumar 157 3 175 2005 10.1016/j.toxlet.2005.03.004 Free heme toxicity and its detoxification systems in human
Blood Kumar 88 11 4348 1996 10.1182/blood.V88.11.4348.bloodjournal88114348 Phorbol ester stimulation increases sickle erythrocyte adherence to endothelium: a novel pathway involving alpha 4 beta 1 integrin receptors on sickle reticulocytes and fibronectin
Nat. Med. Kureishi 6 9 1004 2000 10.1038/79510 The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
J. Biol. Chem. Kuzkaya 278 25 22546 2003 10.1074/jbc.M302227200 Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
Eur. J. Biochem. Lando 270 5 781 2003 10.1046/j.1432-1033.2003.03445.x Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation
FEBS J. Linster 274 1 1 2007 10.1111/j.1742-4658.2006.05607.x Vitamin C. Biosynthesis, recycling and degradation in mammals
Microvasc. Res. Lopes 94 106 2014 10.1016/j.mvr.2014.05.009 In vitro and in vivo anti-angiogenic effects of hydroxyurea
Environ. Toxicol. Pharmacol. Maluf 27 1 26 2009 10.1016/j.etap.2008.08.004 Length of treatment and dose as determinants of mutagenicity in sickle cell disease patients treated with hydroxyurea
J. Biol. Chem. Montecinos 282 21 15506 2007 10.1074/jbc.M608361200 Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Am. J. Hematol. Nur 86 6 484 2011 10.1002/ajh.22012 Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management
Lancet Pacelli 347 9005 900 1996 10.1016/S0140-6736(96)91378-1 Hydroxyurea reacts with heme proteins to generate nitric oxide
Nature Palmer 333 6174 664 1988 10.1038/333664a0 Vascular endothelial cells synthesize nitric oxide from l-arginine
Br. J. Haematol. Rees 156 4 433 2012 10.1111/j.1365-2141.2011.08961.x Biomarkers in sickle cell disease
J. Biol. Chem. Retsky 268 2 1304 1993 10.1016/S0021-9258(18)54075-8 Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions
J. Clin. Invest. Rosch 120 2 627 2010 10.1172/JCI39843 Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease
Biophys. Chem. Rupon 84 1 1 2000 10.1016/S0301-4622(99)00132-5 The reactions of myoglobin, normal adult hemoglobin, sickle cell hemoglobin and hemin with hydroxyurea
Nat. Rev. Mol. Cell Biol. Schofield 5 5 343 2004 10.1038/nrm1366 Oxygen sensing by HIF hydroxylases
Seixas 2014 Biomarkers of steady and crisis states in sickle cell disease patients: roles of heme, MMP-9 and TIMP-1. Manuscript submitted
J. Thromb. Haemost. Setty 6 12 2202 2008 10.1111/j.1538-7836.2008.03177.x Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia
Acta Vitaminol. Enzymol. Som 5 4 243 1983 Ascorbic acid: a scavenger of superoxide radical
Sci. World J. Steinberg 8 1295 2008 10.1100/tsw.2008.157 Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches
Free Radic. Biol. Med. Vissers 42 6 765 2007 10.1016/j.freeradbiomed.2006.11.023 Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate
Proc. Soc. Exp. Biol. Med. Wagener 216 3 456 1997 10.3181/00379727-216-44197 Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells
Arterioscler. Thromb. Vasc. Biol. Wakefield 28 3 387 2008 10.1161/ATVBAHA.108.162289 Mechanisms of venous thrombosis and resolution
Int. J. Vitam. Nutr. Res. Weber 66 1 19 1996 Vitamin C and human health-a review of recent data relevant to human requirements
FASEB J. Wenger 16 10 1151 2002 10.1096/fj.01-0944rev Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
Life Sci. Zhu 83 23-24 801 2008 10.1016/j.lfs.2008.09.029 Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.