[논문]Prognostic Value of Axillary Nodal Ratio after Neoadjuvant Chemotherapy of Doxorubicin/Cyclophosphamide Followed by Docetaxel in Breast Cancer: A Multicenter Retrospective Cohort Study

Kim, Se Hyun; Jung, Kyung Hae; Kim, Tae-Yong; Im, Seock-Ah; Choi, In Sil; Chae, Yee Soo; Baek, Sun Kyung; Kang, Seok Yun; Park, Sarah; Park, In Hae; Lee, Keun Seok; Choi, Yoon Ji; Lee, Soohyeon; Sohn, Joo Hyuk; Park, Yeon-Hee; Im, Young-Hyuck; Ahn, Jin-Hee; Kim, Sung-Bae; Kim, Jee Hyun

doi:10.4143/crt.2015.475

Prognostic Value of Axillary Nodal Ratio after Neoadjuvant Chemotherapy of Doxorubicin/Cyclophosphamide Followed by Docetaxel in Breast Cancer: A Multicenter Retrospective Cohort Study 원문보기

Cancer research and treatment : official journal of Korean Cancer Association, v.48 no.4, 2016년, pp.1373 - 1381

Kim, Se Hyun (Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) , Jung, Kyung Hae (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) , Kim, Tae-Yong (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea) , Im, Seock-Ah (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea) , Choi, In Sil (Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea) , Chae, Yee Soo (Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea) , Baek, Sun Kyung (Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea) , Kang, Seok Yun (Department of Internal Medicine, Ajou University Hospital, Suwon, Korea) , Park, Sarah (Department of Internal Medicine, Seoul St. Mary) , Park, In Hae , Lee, Keun Seok , Choi, Yoon Ji , Lee, Soohyeon , Sohn, Joo Hyuk , Park, Yeon-Hee , Im, Young-Hyuck , Ahn, Jin-Hee , Kim, Sung-Bae , Kim, Jee Hyun

Abstract ▼ AI-Helper

PurposeThe purpose of this study is to investigate the prognostic value of lymph node (LN) ratio (LNR) in patients with breast cancer after neoadjuvant chemotherapy.Materials and MethodsThis retrospective analysis is based on the data of 814 patientswith stage II/III breast cancer treated with four cycles of doxorubicin/cyclophosphamide followed by four cycles of docetaxel before surgery. We evaluated the clinical significance of LNR (3 categories: low 0-0.20 vs. intermediate 0.21-0.65 vs. high 0.66-1.00) using a Cox proportional regression model.ResultsA total of 799 patients underwent breast surgery. Pathologic complete response (pCR, ypT0/isN0) was achieved in 129 patients (16.1%) (hormone receptor [HR] +/human epidermal growth factor receptor 2 [HER2] –, 34/373 [9.1%]; HER2+, 45/210 [21.4%]; triple negative breast cancer, 50/216 [23.1%]). The mean numbers of involved LN and retrieved LN were 2.70 (range, 0 to 42) and 13.98 (range, 1 to 64), respectively. The mean LNR was 0.17 (low, 574 [71.8%]; intermediate, 170 [21.3%]; high, 55 [6.9%]). In univariate analysis, LNR showed significant association with a worse relapse-free survival (3-year relapse-free survival rate 84.8% in low vs. 66.2% in intermediate vs. 54.3% in high; p < 0.001, log-rank test). In multivariate analysis, LNR did not show significant association with recurrence after adjusting for other clinical factors (age, histologic grade, subtype, ypT stage, ypN stage, lymphatic or vascular invasion, and pCR). In subgroup analysis, the LNR system had good prognostic value in HR+/HER2–subtype.ConclusionLNR is not superior to ypN stage in predicting clinical outcome of breast cancer after neoadjuvant chemotherapy. However, the prognostic value of the LNR system in HR+/HER2–patients is notable and worthy of further investigation.

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Prognostic Value of Axillary Nodal Ratio after Neoadjuvant Chemotherapy of Doxorubicin/Cyclophosphamide Followed by Docetaxel in Breast Cancer: A Multicenter Retrospective Cohort Study 원문보기

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