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NTIS 바로가기Genome research, v.27 no.10, 2017년, pp.1645 - 1657
Andrysik, Zdenek (Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA) , Galbraith, Matthew D. , Guarnieri, Anna L. (Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA) , Zaccara, Sara , Sullivan, Kelly D. (Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA) , Pandey, Ahwan , MacBeth, Morgan (Centre for Integrative Biology (CIBIO), University of Trento, 38123 Trento, TN, Italy) , Inga, Alberto , Espinosa, Joaquín M. (Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA)
The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the TP53 gene, while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactivation of its endogenous repres...
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