참고문헌 (44)

1. Adelman K , Kennedy MA , Nechaev S , Gilchrist DA , Muse GW , Chinenov Y , Rogatsky I . 2009 Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling . Proc Natl Acad Sci 106 : 18207 – 18212 . 19820169 

2. Allen MA , Andrysik Z , Dengler VL , Mellert HS , Guarnieri A , Freeman JA , Sullivan KD , Galbraith MD , Luo X , Kraus WL , et al. 2014 Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms . eLife 3 : e02200 . 24867637 

   상세보기

3. Brady CA , Jiang D , Mello SS , Johnson TM , Jarvis LA , Kozak MM , Kenzelmann Broz D , Basak S , Park EJ , McLaughlin ME , 2011 Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression . Cell 145 : 571 – 583 . 21565614 

   상세보기

4. Brummelkamp TR , Fabius AW , Mullenders J , Madiredjo M , Velds A , Kerkhoven RM , Bernards R , Beijersbergen RL . 2006 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors . Nat Chem Biol 2 : 202 – 206 . 16474381 

   상세보기

5. el-Deiry WS , Tokino T , Velculescu VE , Levy DB , Parsons R , Trent JM , Lin D , Mercer WE , Kinzler KW , Vogelstein B . 1993 WAF1, a potential mediator of p53 tumor suppression . Cell 75 : 817 – 825 . 8242752 

   상세보기

6. Fischer M . 2017 Census and evaluation of p53 target genes . Oncogene 36 : 3943 – 3956 . 28288132 

   상세보기

7. Fischer M , Steiner L , Engeland K . 2014 The transcription factor p53: not a repressor, solely an activator . Cell Cycle 13 : 3037 – 3058 . 25486564 

   상세보기

8. Freed-Pastor WA , Prives C . 2012 Mutant p53: one name, many proteins . Genes Dev 26 : 1268 – 1286 . 22713868 

   상세보기

9. Galbraith MD , Allen MA , Bensard CL , Wang X , Schwinn MK , Qin B , Long HW , Daniels DL , Hahn WC , Dowell RD , 2013 HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia . Cell 153 : 1327 – 1339 . 23746844 

   상세보기

10. Gomes NP , Bjerke G , Llorente B , Szostek SA , Emerson BM , Espinosa JM . 2006 Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program . Genes Dev 20 : 601 – 612 . 16510875 

    상세보기

11. Guertin MJ , Lis JT . 2013 Mechanisms by which transcription factors gain access to target sequence elements in chromatin . Curr Opin Genet Dev 23 : 116 – 123 . 23266217 

12. Hainaut P , Pfeifer GP . 2016 Somatic TP53 mutations in the era of genome sequencing . Cold Spring Harb Perspect Med 6 : a026179 . 27503997 

    상세보기

13. Hemann MT , Zilfou JT , Zhao Z , Burgess DJ , Hannon GJ , Lowe SW . 2004 Suppression of tumorigenesis by the p53 target PUMA . Proc Natl Acad Sci 101 : 9333 – 9338 . 15192153 

14. Henry RE , Andrysik Z , Paris R , Galbraith MD , Espinosa JM . 2012 A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX . EMBO J 31 : 1266 – 1278 . 22246181 

    상세보기

15. Jiang L , Kon N , Li T , Wang SJ , Su T , Hibshoosh H , Baer R , Gu W . 2015 Ferroptosis as a p53-mediated activity during tumour suppression . Nature 520 : 57 – 62 . 25799988 

16. Kenzelmann Broz D , Spano Mello S , Bieging KT , Jiang D , Dusek RL , Brady CA , Sidow A , Attardi LD . 2013 Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses . Genes Dev 27 : 1016 – 1031 . 23651856 

    상세보기

17. Kubbutat MH , Jones SN , Vousden KH . 1997 Regulation of p53 stability by Mdm2 . Nature 387 : 299 – 303 . 9153396 

    상세보기

18. Lawrence MS , Stojanov P , Polak P , Kryukov GV , Cibulskis K , Sivachenko A , Carter SL , Stewart C , Mermel CH , Roberts SA , 2013 Mutational heterogeneity in cancer and the search for new cancer-associated genes . Nature 499 : 214 – 218 . 23770567 

19. Lawrence MS , Stojanov P , Mermel CH , Robinson JT , Garraway LA , Golub TR , Meyerson M , Gabriel SB , Lander ES , Getz G . 2014 Discovery and saturation analysis of cancer genes across 21 tumour types . Nature 505 : 495 – 501 . 24390350 

20. Leach FS , Tokino T , Meltzer P , Burrell M , Oliner JD , Smith S , Hill DE , Sidransky D , Kinzler KW , Vogelstein B . 1993 p53 Mutation and MDM2 amplification in human soft tissue sarcomas . Cancer Res 53 : 2231 – 2234 . 8387391 

    상세보기

21. Li M , He Y , Dubois W , Wu X , Shi J , Huang J . 2012a Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells . Mol Cell 46 : 30 – 42 . 22387025 

22. Li T , Kon N , Jiang L , Tan M , Ludwig T , Zhao Y , Baer R , Gu W . 2012b Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence . Cell 149 : 1269 – 1283 . 22682249 

    상세보기

23. Lin C , Garrett AS , De Kumar B , Smith ER , Gogol M , Seidel C , Krumlauf R , Shilatifard A . 2011 Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC) . Genes Dev 25 : 1486 – 1498 . 21764852 

    상세보기

24. Menendez D , Nguyen TA , Freudenberg JM , Mathew VJ , Anderson CW , Jothi R , Resnick MA . 2013 Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells . Nucleic Acids Res 41 : 7286 – 7301 . 23775793 

    상세보기

25. Mermel CH , Schumacher SE , Hill B , Meyerson ML , Beroukhim R , Getz G . 2011 GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers . Genome Biol 12 : R41 . 21527027 

    상세보기

26. Nikulenkov F , Spinnler C , Li H , Tonelli C , Shi Y , Turunen M , Kivioja T , Ignatiev I , Kel A , Taipale J , 2012 Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis . Cell Death Differ 19 : 1992 – 2002 . 22790872 

    상세보기

27. Riemenschneider MJ , Buschges R , Wolter M , Reifenberger J , Bostrom J , Kraus JA , Schlegel U , Reifenberger G . 1999 Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification . Cancer Res 59 : 6091 – 6096 . 10626796 

    상세보기

28. Schlereth K , Heyl C , Krampitz AM , Mernberger M , Finkernagel F , Scharfe M , Jarek M , Leich E , Rosenwald A , Stiewe T . 2013 Characterization of the p53 cistrome—DNA binding cooperativity dissects p53's tumor suppressor functions . PLoS Genet 9 : e1003726 . 23966881 

    상세보기

29. Soussi T , Kato S , Levy PP , Ishioka C . 2005 Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations . Hum Mutat 25 : 6 – 17 . 15580553 

30. Sullivan KD , Padilla-Just N , Henry RE , Porter CC , Kim J , Tentler JJ , Eckhardt SG , Tan AC , DeGregori J , Espinosa JM . 2012 ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53 . Nat Chem Biol 8 : 646 – 654 . 22660439 

    상세보기

31. Takagi M , Absalon MJ , McLure KG , Kastan MB . 2005 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin . Cell 123 : 49 – 63 . 16213212 

    상세보기

32. Timofeev O , Schlereth K , Wanzel M , Braun A , Nieswandt B , Pagenstecher A , Rosenwald A , Elsasser HP , Stiewe T . 2013 p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo . Cell Rep 3 : 1512 – 1525 . 23665223 

    상세보기

33. Tonelli C , Morelli MJ , Sabo A , Verrecchia A , Rotta L , Capra T , Bianchi S , Campaner S , Amati B . 2017 Genome-wide analysis of p53-regulated transcription in Myc-driven lymphomas . Oncogene 36 : 2921 – 2929 . 28092679 

    상세보기

34. Tovar C , Rosinski J , Filipovic Z , Higgins B , Kolinsky K , Hilton H , Zhao X , Vu BT , Qing W , Packman K , 2006 Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy . Proc Natl Acad Sci 103 : 1888 – 1893 . 16443686 

35. Valente LJ , Gray DH , Michalak EM , Pinon-Hofbauer J , Egle A , Scott CL , Janic A , Strasser A . 2013 p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa . Cell Rep 3 : 1339 – 1345 . 23665218 

    상세보기

36. Vassilev LT , Vu BT , Graves B , Carvajal D , Podlaski F , Filipovic Z , Kong N , Kammlott U , Lukacs C , Klein C , 2004 In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 . Science 303 : 844 – 848 . 14704432 

    상세보기

37. Verfaillie A , Svetlichnyy D , Imrichova H , Davie K , Fiers M , Kalender Atak Z , Hulselmans G , Christiaens V , Aerts S . 2016 Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic . Genome Res 26 : 882 – 895 . 27197205 

    상세보기

38. Vousden KH , Prives C . 2009 Blinded by the light: the growing complexity of p53 . Cell 137 : 413 – 431 . 19410540 

    상세보기

39. Vousden KH , Ryan KM . 2009 p53 and metabolism . Nat Rev Cancer 9 : 691 – 700 . 19759539 

    상세보기

40. Wagner A . 2005 Distributed robustness versus redundancy as causes of mutational robustness . Bioessays 27 : 176 – 188 . 15666345 

    상세보기

41. Wang D , Garcia-Bassets I , Benner C , Li W , Su X , Zhou Y , Qiu J , Liu W , Kaikkonen MU , Ohgi KA , 2011 Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA . Nature 474 : 390 – 394 . 21572438 

42. Wang B , Niu D , Lam TH , Xiao Z , Ren EC . 2014 Mapping the p53 transcriptome universe using p53 natural polymorphs . Cell Death Differ 21 : 521 – 532 . 24076587 

    상세보기

43. Wei CL , Wu Q , Vega VB , Chiu KP , Ng P , Zhang T , Shahab A , Yong HC , Fu Y , Weng Z , 2006 A global map of p53 transcription-factor binding sites in the human genome . Cell 124 : 207 – 219 . 16413492 

    상세보기

44. Zaccara S , Tebaldi T , Pederiva C , Ciribilli Y , Bisio A , Inga A . 2014 p53-directed translational control can shape and expand the universe of p53 target genes . Cell Death Differ 21 : 1522 – 1534 . 24926617 

    상세보기