다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Cellular physiology and biochemistry, v.46 no.5, 2018년, pp.2138 - 2148
Pan, Shengli (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China) , Deng, Yingying (Department of Ophthalmology, Shanghai Eighth People Hospital, Shanghai, China) , Fu, Jun (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China) , Zhang, Yuhao (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China) , Zhang, Zhijin (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China) , Ru, Xiaokun (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China) , Qin, Xianju (Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Shanghai, China)
AI-Helper
Background/Aims: A few Rho GTPase activating proteins (RhoGAPs) have been identified as tumor suppressors in a variety of human cancers. ARHGAP17, a member of RhoGAPs, has been reported to be involved in the maintenance of tight junction and epithelial barrier. The present study aimed to explore its...
1 Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90. 10.3322/caac.20107 21296855
2 Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in globocan 2012 Int J Cancer 2015; 136:E359-386. 10.1002/ijc.29210 25220842
3 Slattery ML: Diet, lifestyle, and colon cancer. Semin Gastrointest Dis 2000; 11: 142-146. 10950460
4 Kuiper JG, Phipps AI, Neuhouser ML, Chlebowski RT, Thomson CA, Irwin ML, Lane DS, Wactawski-Wende J, Hou L, Jackson RD, Kampman E, Newcomb PA: Recreational physical activity, body mass index, and survival in women with colorectal cancer. Cancer Causes Control 2012; 23: 1939-1948. 10.1007/s10552-012-0071-2 23053793
5 Huxley RR, Ansary-Moghaddam A, Clifton P, Czernichow S, Parr CL, Woodward M: The impact of dietary and lifestyle risk factors on risk of colorectal cancer: A quantitative overview of the epidemiological evidence. Int J Cancer 2009; 125: 171-180. 10.1002/ijc.24343 19350627
6 Bellam N, Pasche B: Tgf-beta signaling alterations and colon cancer. Cancer Treat Res 2010; 155: 85-103. 10.1007/978-1-4419-6033-7_5 20517689
7 Huang XF, Chen JZ: Obesity, the pi3k/akt signal pathway and colon cancer. Obes Rev 2009; 10: 610-616. 10.1111/j.1467-789X.2009.00607.x 19527447
8 Fang JY, Richardson BC: The mapk signalling pathways and colorectal cancer. Lancet Oncol 2005; 6: 322-327. 10.1016/S1470-2045(05)70168-6 15863380
9 Bienz M, Clevers H: Linking colorectal cancer to wnt signaling. Cell 2000; 103: 311-320. 10.1016/S0092-8674(00)00122-7 11057903
10 Jaffe AB, Hall A: Rho gtpases: Biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247-269. 10.1146/annurev.cellbio.21.020604.150721 16212495
11 Luo L: Rho gtpases in neuronal morphogenesis. Nat Rev Neurosci 2000; 1: 173-180. 10.1038/35044547 11257905
12 Braun AC, Olayioye MA: Rho regulation: Dlc proteins in space and time. Cell Signal 2015; 27: 1643-1651. 10.1016/j.cellsig.2015.04.003 25889896
13 Harada A, Furuta B, Takeuchi K, Itakura M, Takahashi M, Umeda M: Nadrin, a novel neuron-specific gtpase-activating protein involved in regulated exocytosis. J Biol Chem 2000; 275: 36885-36891. 10.1074/jbc.M004069200 10967100
14 Richnau N, Aspenstrom P: Rich, a rho gtpase-activating protein domain-containing protein involved in signaling by cdc42 and rac1 J Biol Chem 2001; 276: 35060-35070. 10.1074/jbc.M103540200 11431473
15 Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila JL, Christian N, Persson NL, Shimono A, Speicher DW, Marmorstein R, Holmgren L, Kissil JL: A tight junction-associated merlin-angiomotin complex mediates merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell 2011; 19: 527-540. 10.1016/j.ccr.2011.02.017 21481793
16 Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T: A rich1/amot complex regulates the cdc42 gtpase and apical-polarity proteins in epithelial cells. Cell 2006; 125: 535-548. 10.1016/j.cell.2006.02.045 16678097
17 Lee SY, Kim H, Kim K, Lee H, Lee S, Lee D: Arhgap17, a rhogtpase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Sci Rep 2016; 6: 26923. 10.1038/srep26923 27229483
18 Hong Y, Downey T, Eu KW, Koh PK, Cheah PY: A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis 2010; 27: 83-90. 10.1007/s10585-010-9305-4 20143136
19 Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102: 15545-15550. 10.1073/pnas.0506580102 16199517
20 Anastas JN, Moon RT: Wnt signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 11-26. 10.1038/nrc3419 23258168
21 Clevers H, Nusse R: Wnt/beta-catenin signaling and disease. Cell 2012; 149: 1192-1205. 10.1016/j.cell.2012.05.012 22682243
22 Ji D, Chen Z, Li M, Zhan T, Yao Y, Zhang Z, Xi J, Yan L, Gu J: Microrna-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor wif-1 Mol Cancer 2014; 13: 86. 10.1186/1476-4598-13-86 24755295
23 Ravi A, Kaushik S, Ravichandran A, Pan CQ, Low BC: Epidermal growth factor activates the rho gtpase-activating protein (gap) deleted in liver cancer 1 via focal adhesion kinase and protein phosphatase 2a. J Biol Chem 2015; 290: 4149-4162. 10.1074/jbc.M114.616839 25525271
24 Tripathi BK, Qian X, Mertins P, Wang D, Papageorge AG, Carr SA, Lowy DR: Cdk5 is a major regulator of the tumor suppressor dlc1 J Cell Biol 2014; 207: 627-642. 10.1083/jcb.201405105 25452387
25 Wang J, Qian J, Hu Y, Kong X, Chen H, Shi Q, Jiang L, Wu C, Zou W, Chen Y, Xu J, Fang JY: Arhgap30 promotes p53 acetylation and function in colorectal cancer. Nat Commun 2014; 5: 4735. 10.1038/ncomms5735 25156493
26 Huang GH, Yang XT, Chen K, Xing J, Guo L, Zhu L, Li HJ, Li XC, Zhang SY, Feng DF: Porf-2 inhibits neural stem cell proliferation through wnt/beta-catenin pathway by its gap domain. Front Cell Neurosci 2016; 10: 85. 10.3389/fncel.2016.00085 27064446
27 Fang YJ, Lu ZH, Wang GQ, Pan ZZ, Zhou ZW, Yun JP, Zhang MF, Wan DS: Elevated expressions of mmp7, trop2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis 2009; 24: 875-884. 10.1007/s00384-009-0725-z 19421758
28 Gonzalez-Sancho JM, Aguilera O, Garcia JM, Pendas-Franco N, Pena C, Cal S, Garcia de Herreros A, Bonilla F, Munoz A: The wnt antagonist dickkopf-1 gene is a downstream target of beta-catenin/tcf and is downregulated in human colon cancer. Oncogene 2005; 24: 1098-1103. 10.1038/sj.onc.1208303 15592505
29 Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, Cocito A, Amati B: Genomic targets of the human c-myc protein. Genes Dev 2003; 17: 1115-1129. 10.1101/gad.1067003 12695333
30 Adachi Y, Yamamoto H, Itoh F, Hinoda Y, Okada Y, Imai K: Contribution of matrilysin (mmp-7) to the metastatic pathway of human colorectal cancers. Gut 1999; 45: 252-258. 10.1136/gut.45.2.252 10403738
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.