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Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects 원문보기

PLoS pathogens, v.8 no.10, 2012년, pp.e1002976 -   

Jurgeit, Andreas (Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland) ,  McDowell, Robert (3-V Biosciences Inc., Menlo Park, California, United States of America) ,  Moese, Stefan (3-V Biosciences Inc., Menlo Park, California, United States of America) ,  Meldrum, Eric (3-V Biosciences Inc., Menlo Park, California, United States of America) ,  Schwendener, Reto (Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland) ,  Greber, Urs F. (Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland)

Abstract AI-Helper 아이콘AI-Helper

Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We identified the salicylanilide niclosamide as a broad range antiviral agent targeting acidified endosomes. Niclosamide is approved for human use a...

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