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NTIS 바로가기PLoS pathogens, v.8 no.10, 2012년, pp.e1002976 -
Jurgeit, Andreas (Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland) , McDowell, Robert (3-V Biosciences Inc., Menlo Park, California, United States of America) , Moese, Stefan (3-V Biosciences Inc., Menlo Park, California, United States of America) , Meldrum, Eric (3-V Biosciences Inc., Menlo Park, California, United States of America) , Schwendener, Reto (Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland) , Greber, Urs F. (Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland)
Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We identified the salicylanilide niclosamide as a broad range antiviral agent targeting acidified endosomes. Niclosamide is approved for human use a...
1 Fleming A ( 1929 ) On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae . Br J Exp Path 10 : 226 – 36 .
2 Yazdanpanah Y ( 2009 ) Multidrug resistance: a clinical approach . Curr Opin HIV AIDS 4 : 499 – 506 . 20048717
3 Le Gall O , Christian P , Fauquet CM , King AM , Knowles NJ , et al ( 2008 ) Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T = 3 virion architecture . Arch Virol 153 : 715 – 727 . 18293057
4 Hayden FG ( 2004 ) Rhinovirus and the lower respiratory tract . Rev Med Virol 14 : 17 – 31 . 14716689
5 Fuchs R , Blaas D ( 2010 ) Uncoating of human rhinoviruses . Rev Med Virol 20 : 281 – 297 . 20629045
6 Bochkov YA , Palmenberg AC , Lee WM , Rathe JA , Amineva SP , et al ( 2011 ) Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C . Nat Med 17 : 627 – 632 . 21483405
7 Fendrick AM , Monto AS , Nightengale B , Sarnes M ( 2003 ) The economic burden of non-influenza-related viral respiratory tract infection in the United States . Arch Intern Med 163 : 487 – 494 . 12588210
8 Florea NR , Maglio D , Nicolau DP ( 2003 ) Pleconaril, a novel antipicornaviral agent . Pharmacotherapy 23 : 339 – 348 . 12627933
9 Kaiser L , Crump CE , Hayden FG ( 2000 ) In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses . Antiviral Res 47 : 215 – 220 . 10974374
10 Ditzel J , Schwartz M ( 1967 ) Worm cure without tears. The effect of niclosamide on taeniasis saginata in man . Acta Medica Scandinavica 182 : 663 – 664 . 6057575
11 anonymous (1988) Data sheet on pesticides No 63: niclosamide. World Health Organisation (WHO): Food and Agriculture Organisation: International Programme on Chemical Safety, Inchem. pp. WHO/VBC/DS/88.63.
12 Sharma S, Anand N (1997) Approaches to design and synthesis of antiparasitic drugs. Pharmacochemistry library v 25. Amsterdam; New York: Elsevier. 511 p.
13 Wu CJ , Jan JT , Chen CM , Hsieh HP , Hwang DR , et al ( 2004 ) Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide . Antimicrob Agents Chemother 48 : 2693 – 2696 . 15215127
14 Zhu PJ , Hobson JP , Southall N , Qiu C , Thomas CJ , et al ( 2009 ) Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death . Bioorg Med Chem 17 : 5139 – 5145 . 19540764
15 Osada T , Chen M , Yang XY , Spasojevic I , Vandeusen JB , et al ( 2011 ) Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations . Cancer Res 71 : 4172 – 4182 . 21531761
16 Balgi AD , Fonseca BD , Donohue E , Tsang TC , Lajoie P , et al ( 2009 ) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling . PLoS One 4 : e7124 . 19771169
17 Chen M , Wang J , Lu J , Bond MC , Ren XR , et al ( 2009 ) The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling . Biochemistry 48 : 10267 – 10274 . 19772353
18 Wang AM , Ku HH , Liang YC , Chen YC , Hwu YM , et al ( 2009 ) The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells . J Cell Biochem 106 : 682 – 692 . 19160421
19 Fonseca BD , Diering GH , Bidinosti MA , Dalal K , Alain T , et al ( 2012 ) Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling . J Biol Chem 287 : 17530 – 17545 . 22474287
20 Weinbach EC , Garbus J ( 1969 ) Mechanism of action of reagents that uncouple oxidative phosphorylation . Nature 221 : 1016 – 1018 . 4180173
21 Jurgeit A , Moese S , Roulin P , Dorsch A , Lotzerich M , et al ( 2010 ) An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections . Virol J 7 : 264 . 20937137
22 Thibaut HJ , De Palma AM , Neyts J ( 2012 ) Combating enterovirus replication: state-of-the-art on antiviral research . Biochem Pharmacol 83 : 185 – 192 . 21889497
23 Dunn WA , Hubbard AL , Aronson NN Jr ( 1980 ) Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver . J Biol Chem 255 : 5971 – 5978 . 6155379
24 Nurani G , Lindqvist B , Casasnovas JM ( 2003 ) Receptor priming of major group human rhinoviruses for uncoating and entry at mild low-pH environments . J Virol 77 : 11985 – 11991 . 14581535
25 Pevear DC , Tull TM , Seipel ME , Groarke JM ( 1999 ) Activity of pleconaril against enteroviruses . Antimicrob Agents Chemother 43 : 2109 – 2115 . 10471549
26 Brabec M , Baravalle G , Blaas D , Fuchs R ( 2003 ) Conformational changes, plasma membrane penetration, and infection by human rhinovirus type 2: role of receptors and low pH . J Virol 77 : 5370 – 5377 . 12692239
27 Matlin KS , Reggio H , Helenius A , Simons K ( 1981 ) Infectious entry pathway of influenza virus in a canine kidney cell line . J Cell Biol 91 : 601 – 613 . 7328111
28 Bayer N , Schober D , Prchla E , Murphy RF , Blaas D , et al ( 1998 ) Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: implications for viral uncoating and infection . J Virol 72 : 9645 – 9655 . 9811698
29 Palmgren MG ( 1991 ) Acridine-Orange as a Probe for Measuring Ph Gradients across Membranes - Mechanism and Limitations . Anal Biochem 192 : 316 – 321 . 1827963
30 Forgac M ( 2007 ) Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology . Nat Rev Mol Cell Biol 8 : 917 – 929 . 17912264
31 Rogers J , Hesketh TR , Smith GA , Beaven MA , Metcalfe JC , et al ( 1983 ) Intracellular pH and free calcium changes in single cells using quene 1 and quin 2 probes and fluorescence microscopy . FEBS letters 161 : 21 – 27 . 6884525
32 Huotari J , Helenius A ( 2011 ) Endosome maturation . Embo J 30 : 3481 – 3500 . 21878991
33 Anonymous ( 2002 ) WHO SPECIFICATIONS AND EVALUATIONS FOR PUBLIC HEALTH PESTICIDES: Niclosamide . WORLD HEALTH ORGANIZATION GENEVA 1 – 24 .
34 Galloway CJ , Dean GE , Marsh M , Rudnick G , Mellman I ( 1983 ) Acidification of macrophage and fibroblast endocytic vesicles in vitro . Proc Natl Acad Sci U S A 80 : 3334 – 3338 . 6190176
35 Wermuth CG ( 2004 ) Selective optimization of side activities: another way for drug discovery . J Med Chem 47 : 1303 – 1314 . 14998318
36 Andrews P , Thyssen J , Lorke D ( 1982 ) The biology and toxicology of molluscicides, Bayluscide . Pharmacol Ther 19 : 245 – 295 . 6763710
37 Korba BE , Montero AB , Farrar K , Gaye K , Mukerjee S , et al ( 2008 ) Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication . Antiviral Res 77 : 56 – 63 . 17888524
38 Rossignol JF , Abu-Zekry M , Hussein A , Santoro MG ( 2006 ) Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial . Lancet 368 : 124 – 129 . 16829296
39 Rossignol JF ( 2009 ) Thiazolides: a new class of antiviral drugs . Expert Opin Drug Metab Toxicol 5 : 667 – 674 . 19442032
40 Stachulski AV , Pidathala C , Row EC , Sharma R , Berry NG , et al ( 2011 ) Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication . J Med Chem
41 Rossignol JF , La Frazia S , Chiappa L , Ciucci A , Santoro MG ( 2009 ) Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level . J Biol Chem 284 : 29798 – 29808 . 19638339
42 de Carvalho LP , Darby CM , Rhee KY , Nathan C ( 2011 ) Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis . ACS Med Chem Lett 2 : 849 – 854 . 22096616
43 Elazar M , Liu M , McKenna SA , Liu P , Gehrig EA , et al ( 2009 ) The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation . Gastroenterology 137 : 1827 – 1835 . 19664635
44 Yang YL , Reis LF , Pavlovic J , Aguzzi A , Schafer R , et al ( 1995 ) Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase . Embo J 14 : 6095 – 6106 . 8557029
45 Wen CC , Kuo YH , Jan JT , Liang PH , Wang SY , et al ( 2007 ) Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus . J Med Chem 50 : 4087 – 4095 . 17663539
46 Zhang XW , Yap YL ( 2004 ) Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs . Bioorg Med Chem 12 : 2517 – 2521 . 15110833
47 Casey JR , Grinstein S , Orlowski J ( 2010 ) Sensors and regulators of intracellular pH . Nat Rev Mol Cell Biol 11 : 50 – 61 . 19997129
48 Ohkuma S , Poole B ( 1978 ) Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents . Proc Natl Acad Sci U S A 75 : 3327 – 3331 . 28524
49 Helenius A , Marsh M , White J ( 1982 ) Inhibition of Semliki Forest virus penetration by lysosomotropic weak bases . J Gen Virol 58 : 47 – 61 . 7142969
50 Greber UF , Willetts M , Webster P , Helenius A ( 1993 ) Stepwise dismantling of adenovirus 2 during entry into cells . Cell 75 : 477 – 486 . 8221887
51 Blanchard E , Belouzard S , Goueslain L , Wakita T , Dubuisson J , et al ( 2006 ) Hepatitis C virus entry depends on clathrin-mediated endocytosis . J Virol 80 : 6964 – 6972 . 16809302
52 Acosta EG , Castilla V , Damonte EB ( 2008 ) Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis . J Gen Virol 89 : 474 – 484 . 18198378
53 Zoratti M , Favaron M , Pietrobon D , Petronilli V ( 1984 ) Nigericin-induced transient changes in rat-liver mitochondria . Biochim Biophys Acta 767 : 231 – 239 . 6498179
54 Steinberg BE , Huynh KK , Brodovitch A , Jabs S , Stauber T , et al ( 2010 ) A cation counterflux supports lysosomal acidification . J Cell Biol 189 : 1171 – 86 . 20566682
55 Pinkerton M , Steinrauf LK ( 1970 ) Molecular structure of monovalent metal cation complexes of monensin . J Mol Biol 49 : 533 – 546 . 5453344
56 Frelin C , Barbry P , Vigne P , Chassande O , Cragoe EJ Jr , et al ( 1988 ) Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger . Biochimie 70 : 1285 – 1290 . 2852509
57 Hurtado-Lorenzo A , Skinner M , El Annan J , Futai M , Sun-Wada GH , et al ( 2006 ) V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway . Nat Cell Biol 8 : 124 – 136 . 16415858
58 Spearman C ( 1908 ) The Method of ‘Right and Wrong Cases’ (Constant Stimuli) without Gauss' Formulae . Brit J Psychology 2 : 227 – 442 .
59 Crider BP , Xie XS ( 2003 ) Characterization of the functional coupling of bovine brain vacuolar-type H(+)-translocating ATPase. Effect of divalent cations, phospholipids, and subunit H (SFD) . J Biol Chem 278 : 44281 – 44288 . 12949075
60 Czekanska EM ( 2011 ) Assessment of cell proliferation with resazurin-based fluorescent dye . Methods Mol Biol 740 : 27 – 32 . 21468965
61 Prichard MN , Shipman C Jr ( 1990 ) A three-dimensional model to analyze drug-drug interactions . Antiviral Res 14 : 181 – 205 . 2088205
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