[논문]Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells

Zheng, XiaoLei; Xie, ZhaoHong; Zhu, ZhengYu; Liu, Zhen; Wang, Yun; Wei, LiFei; Yang, Hui; Yang, HongNa; Liu, YiQing; Bi, JianZhong

doi:10.1371/journal.pone.0111536

Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells 원문보기

PloS one, v.9 no.10, 2014년, pp.e111536 -

Zheng, XiaoLei (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Xie, ZhaoHong (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Zhu, ZhengYu (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Liu, Zhen (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Wang, Yun (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Wei, LiFei (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Yang, Hui (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Yang, HongNa (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Liu, YiQing (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China) , Bi, JianZhong (Department of Neural Medicine, Second Hospital of Shandong University, Jinan, China)

Abstract ▼ AI-Helper

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. As the most common form of dementia, it affects more than 35 million people worldwide and is increasing. Excessive extracellular deposition of amyloid-β peptide (Aβ) is a pathologic feature of AD. Accumulating evidence indicates that macroautophagy is involved in the pathogenesis of AD, but its exact role is still unclear. Although major findings on the molecular mechanisms have been reported, there are still no effective treatments to prevent, halt, or reverse Alzheimer's disease. In this study, we investigated whether Aβ25–35 could trigger an autophagy process and inhibit the growth of SH-SY5Y cells. Furthermore, we examined the effect of methyllycaconitine (MLA) on the cytotoxity of Aβ25–35. MLA had a protective effect against cytotoxity of Aβ, which may be related to its inhibition of Aβ-induced autophagy and the involvement of the mammalian target of rapamycin pathway. Moreover, MLA had a good safety profile. MLA treatment may be a promising therapeutic tool for AD.

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Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells 원문보기

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