[논문]Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice

Liu, Bihui; Zhang, Jing; Yi, Ruokun; Zhou, Xianrong; Long, Xingyao; Pan, Yanni; Zhao, Xin

doi:10.3390/foods8030093

Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice 원문보기

Foods, v.8 no.3, 2019년, pp.93 -

Liu, Bihui (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China) , Zhang, Jing (liubh@foods.ac.cn (B.L.)) , Yi, Ruokun (yirk@cque.edu.cn (R.Y.)) , Zhou, Xianrong (zhouxr@foods.ac.cn (X.Z.)) , Long, Xingyao (longyaoyao@foods.ac.cn (X.L.)) , Pan, Yanni (panyanni@foods.ac.cn (Y.P.)) , Zhao, Xin (Environment and Quality Inspection College, Chongqing Chemical Industry Vocational College, Chongqing 401228, China)

Abstract ▼ AI-Helper

Lactobacillus fermentum CQPC08 (LF-CQPC08) is a newly discovered strain of bacteria isolated and identified from traditional pickled vegetables in Sichuan, China. We used 4-nitroquinoline 1-oxide to establish an experimental tongue cancer mouse model to evaluate the preventive effect of LF-CQPC08 on tongue cancer in vivo. Lactobacillus delbruechii subsp. bulgaricus, is a common commercial strain and is used as a positive control to compare the effect with LF-CQPC08. The preventive strength and mechanism of LF-CQPC08 on tongue cancer were determined by measuring the biochemical indicators in mouse serum and tissues. Our results showed LF-CQPC08 inhibits the decline of splenic index, thymus index, percentage of phagocytic macrophages, and phagocytic index effectively. LF-CQPC08 also increased levels of mouse serum granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage-CSF (GM-CSF), immunoglobulin (Ig)G, IgM levels of serum interleukin (IL)-4, IL-12, tumor necrosis factor-alpha, and interferon-gamma levels, thereby inhibiting the decline in immunity caused by tongue cancer. It also increased the activity levels of superoxide dismutase and glutathione peroxidase and decreased the levels of malondialdehyde in the tissues of the tongue cancer mouse model, thereby suppressing the oxidative stress damage in the tissue caused by tongue cancer. Through quantitative PCR, LF-CQPC08 upregulated the mRNA expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), heme oxygenase-1 (HO-1), glutathione-S-transferases-π (GST-π), and Bcl-2-associated X protein (Bax), and downregulated the mRNA expression of p53, p63, p73, phosphatase and tensin homolog (PTEN), B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL) in the tongue tissues of the tongue cancer mouse. These results indicated that LF-CQPC08 reduced the influence of tongue cancer on the immune system and oxidative balance and improved the immunity and enhanced antioxidant capacity of the mouse model, thereby preventing tongue cancer. LF-CQPC08 could be used as a microbial resource with a preventive effect on tongue cancer.

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참고문헌 (47)

1. Gong J.Y. Ye J. Yang S. Liu L. Chen J.J. Research and design of the tumorous stem mustard harvester J. Agric. Mech. Res. 2018 40 120 124
2. Chen G. Yu W.H. Zhang Q.S. Song P. Zhang B.B. Liu Z. You J.G. Li H. Research of Sichuan Paocai and Lactic Acid Bacteria Adv. J. Food Sci. Technol. 2014 6 1 5
3. Huang Y. Luo Y.B. Zhai Z.Y. Zhang H.X. Yang C.X. Tian H.T. Li Z. Feng J.N. Liu H. Hao Y.L. Characterization and application of an anti-Listeria bacteriocin produced by Pediococcus pentosaceus 05-10 isolated from Sichuan Pickle, a traditionally fermented vegetable product from China Food Control 2009 20 1030 1035 10.1016/j.foodcont.2008.12.008

상세보기
4. Liu A. Li X. Pu B. Ao X. Zhou K. He L. Chen S. Liu S. Use of psychrotolerant lactic acid bacteria ( Lactobacillus spp. and Leuconostoc spp.) Isolated from Chinese Traditional Paocai for the Quality Improvement of Paocai Products J. Agric. Food Chem. 2017 65 2580 2587 10.1021/acs.jafc.7b00050 28276234

상세보기
5. Liu W.L. Zhang L.W. Shi J. Yi H.X. Effect of complex food environment on production of enteriocin IN 3531 with Enterococcus faecium IN3531 as a starter in Chinese fermentation Paocai making Adv. Mater. Res. 2014 884–885 429 432 10.4028/www.scientific.net/AMR.884-885.429

상세보기
6. Zhang J. Zhou X. Chen B. Long X. Mu J. Pan Y. Song J.-L. Zhao X. Yang Z. Preventive effect of Lactobacillus plantarum CQPC10 on activated carbon induced constipation in Institute of Cancer Research (ICR) mice Appl. Sci. 2018 8 1498 10.3390/app8091498

상세보기
7. Qian Y. Zhang J. Zhou X. Yi R. Mu J. Long X. Pan Y. Zhao X. Liu W. Lactobacillus plantarum CQPC11 isolated from Sichuan pickled cabbages antagonizes d-galactose-induced oxidation and aging in mice Molecules 2018 23 3026 10.3390/molecules23113026 30463304

상세보기
8. Qian Y. Song J.-L. Yi R. Li G. Sun P. Zhao X. Huo G. Preventive effects of Lactobacillus plantarum YS4 on constipation induced by activated carbon in mice Appl. Sci. 2018 8 363 10.3390/app8030363

상세보기
9. Chen X. Zhao X. Wang H. Yang Z. Li J. Suo H. Prevent effects of Lactobacillus fermentum HY01 on dextran sulfate sodium-induced colitis in mice Nutrients 2017 9 545 10.3390/nu9060545 28587089

상세보기
10. Chen X. Zhang J. Yi R. Mu J. Zhao X. Yang Z. Hepatoprotective effects of Lactobacillus on carbon tetrachloride-induced acute liver injury in mice Int. J. Mol. Sci. 2018 19 2212 10.3390/ijms19082212 30060611

상세보기
11. Chen X. Tan F. Yi R. Mu J. Zhao X. Yang Z. Effects of Lactobacillus on mice with diabetes induced by high-fat diet with streptozotocin (STZ) Appl. Sci. 2018 8 1249 10.3390/app8081249

상세보기
12. Bartkiene E. Zavistanaviciute P. Lele V. Ruzauskas M. Bartkevics V. Bernatoniene J. Gallo P. Tenore G.C. Santini A. Lactobacillus plantarum LUHS135 and paracasei LUHS244 as functional starter cultures for the food fermentation industry: Characterisation, mycotoxin-reducing properties, optimisation of biomass growth and sustainable encapsulation by using dairy by-products LWT-Food Sci. Technol. 2018 93 649 658
13. Zhang J. Chen B. Liu B. Zhou X. Mu J. Wang Q. Zhao X. Yang Z. Preventive effect of Lactobacillus fermentum CQPC03 on activated carbon-induced constipation in ICR mice Medicina 2018 54 89 10.3390/medicina54050089 30463207

상세보기
14. Watari J. Chen N. Amenta P.S. Fukui H. Oshima T. Tomita T. Miwa H. Lim K.J. Das K.M. Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development World J. Gastroenterol. 2014 20 5461 5473 10.3748/wjg.v20.i18.5461 24833876

상세보기
15. Shichijo S. Hirata Y. Sakitani K. Yamamoto S. Serizawa T. Niikura R. Watabe H. Yoshida S. Yamada A. Yamaji Y. Distribution of intestinal metaplasia as a predictor of gastric cancer development J. Gastroenterol. Hepatol. 2015 30 1260 1264 10.1111/jgh.12946 25777777

상세보기
16. González C.A. Sanz-Anquela J.M. Gisbert J.P. Correa P. Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence Int. J. Cancer 2013 133 1023 1032 10.1002/ijc.28003 23280711

상세보기
17. Xi J. He L. Yan L. Kinetic modeling of pressure-assisted solvent extraction of polyphenols from green tea in comparison with the conventional extraction Food Chem. 2005 166 287 291 10.1016/j.foodchem.2014.06.026 25053058

상세보기
18. Zhao X. Pang L. Li J. Song J.L. Qiu L.H. Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885 Nutrients 2014 6 3084 3100 10.3390/nu6083084 25100434

상세보기
19. Ward D.M. Weller R. Bateson M.M. 16S rRNA sequences reveal numerous uncultured microorganisms in a natural community Nature 1990 345 63 65 10.1038/345063a0 1691827

상세보기
20. Steidler N.E. Reade P.C. Initiation and promotion of experimental oral mucosal carcinogenesis in mice J. Oral Pathol. 1986 15 43 47 10.1111/j.1600-0714.1986.tb00562.x 3080566

상세보기
21. Chen L. Pan D.D. Zhou J. Jiang Y.Z. Protective effect of selenium-enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms World J. Gastroenterol. 2005 11 5795 5800 10.3748/wjg.v11.i37.5795 16270387

상세보기
22. Yao Y. Chen L. Xiao J. Wang C. Jiang W. Zhang R. Hao J. Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation Int. J. Mol. Sci. 2014 15 20913 20926 10.3390/ijms151120913 25402649

상세보기
23. Zhang Z.J. Feng X. Jiang J. Xiao P. Influence of Pachyman on biosynthesis level of mice serum IgA, IgG and IgM Chin. J. Immunol. 2013 29 1213 1215
24. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res. 2001 29 e45 10.1093/nar/29.9.e45 11328886

상세보기
25. Qian Y. Zhang J. Fu X. Yi R. Sun P. Zou M. Long X. Zhao X. Preventive effect of raw Liubao tea polyphenols on mouse gastric injuries induced by HCl/ethanol via anti-oxidative stress Molecules 2018 23 2848 10.3390/molecules23112848 30388863

상세보기
26. Suo H. Zhao X. Qian Y. Sun P. Zhu K. Li J. Sun B. Lactobacillus fermentum Suo attenuates HCl/ethanol induced gastric injury in mice through its antioxidant effects Nutrients 2016 8 155 10.3390/nu8030155 26978395

상세보기
27. Suo H. Feng X. Zhu K. Wang C. Zhao X. Kan J. Shuidouchi (fermented soybean) fermented in different vessels attenuates HCl/ethanol-induced gastric mucosal injury Molecules 2015 20 19748 19763 10.3390/molecules201119654 26540032

상세보기
28. Zhao X. Yi R. Qian Y. Park K.Y. Lactobacillus plantarum YS-3 prevents activated carbon-induced constipation in mice J. Med. Food 2018 21 575 584 10.1089/jmf.2017.4109 29757072

상세보기
29. Zhou Y.L. Wang R. Feng X. Zhao X. Preventive effect of insect tea against reserpine-induced gastric ulcers in mice Exp. Ther. Med. 2014 8 1318 1324 10.3892/etm.2014.1859 25187847

상세보기
30. Chen S.C. Zhu K. Wang R. Zhao X. Preventive effect of polysaccharides from the large yellow croaker swim bladder on HCl/ethanol induced gastric injury in mice Exp. Ther. Med. 2014 5 316 322 10.3892/etm.2014.1712 24944640

상세보기
31. Sugimoto M. Ohno T. Graham D.Y. Yamaoka Y. Helicobacter pylori outer membrane proteins on gastric mucosal interleukin 6 and 11 expression in Mongolian gerbils J. Gastroenterol. Hepatol. 2011 26 1677 1684 10.1111/j.1440-1746.2011.06817.x 21679252

상세보기
32. Tugues S. Burkhard S.H. Ohs I. Vrohlings M. Nussbaum K. vom Berg J. Kulig P. Becher B. New insights into IL-12-mediated tumor suppression Cell Death Differ. 2015 22 237 246 10.1038/cdd.2014.134 25190142

상세보기
33. Liu P. Chen L. Zhang H. Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell-based immunotherapy J. Immunol. Res. 2018 2018 1206737 10.1155/2018/1206737 30255103

상세보기
34. Werawatganon D. Rakananurak N. Sallapant S. Prueksapanich P. Somanawat K. Klaikeaw N. Rerknimitr R. Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats World J. Gastroenterol. 2014 20 18330 18337 10.3748/wjg.v20.i48.18330 25561799

상세보기
35. Qian Y. Li G.J. Zhu K. Suo H.Y. Sun P. Zhao X. Effects of three types of resistant starch on intestine and their gastric ulcer preventive activities in vivo J. Korean Soc. Appl. Biol. Chem. 2013 56 739 746 10.1007/s13765-013-3229-z

원문보기 상세보기
36. Kawabata A. Kinoshita M. Nishikawa H. Kuroda R. Nishida M. Araki H. Arizono N. Oda Y. Kakehi K. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection J. Clin. Investig. 2001 107 1443 1450 10.1172/JCI10806 11390426

상세보기
37. Piao X. Li S. Sui X. Guo L. Liu X. Li H. Gao L. Cai S. Li Y. Wang T. 1-deoxynojirimycin (DNJ) ameliorates indomethacin-induced gastric ulcer in mice by affecting NF-kappaB signaling pathway Front Pharmacol. 2018 9 372 10.3389/fphar.2018.00372 29725297

상세보기
38. Yi S.X. Yang R.D. Yan J. Chang X.R. Ling Y.P. Effect of electro-acupuncture at Foot-Yangming Meridian on somatostatin and expression of somatostatin receptor genes in rabbits with gastric ulcer World J. Gastroenterol. 2006 12 1761 1765 10.3748/wjg.v12.i11.1761 16586548

상세보기
39. Du Y. Zhao W. Lu L. Zheng J. Hu X. Yu Z. Zhu L. Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α (TNF-α) and endothelin-1 (ET-1) Asian Pac. J. Trop. Biomed. 2013 3 925 930 10.1016/S2221-1691(13)60180-X 24093781

상세보기
40. Cao L. Wang L.H. Liu T.J. Liu B.Y. Expressions of p73, p63 and p53 in oral squamous cell carcinoma and their clinical significance J. Pract. Med. 2008 24 3864 3866
41. Yang Y.P. Cao Y. Qin H.Y. Expression of p73, p63 and p53 in tongue squamous cell carcinoma J. Clin. Stomatol. 2002 18 409 411
42. Zhou C.X. Gao W.X. Gao Y. Expression and significance of PTEN, p27 in oral leukoplakia and oral squamous cell carcinoma J. Mod. Somatol. 2004 18 499 502
43. Zhang M. An C. Gao Y. Leak R.K. Chen J. Zhang F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Prog. Neurobiol. 2013 100 30 47 10.1016/j.pneurobio.2012.09.003 23025925

상세보기
44. Was H. Sokolowska M. Sierpniowska A. Dominik P. Skrzypek K. Lackowska B. Pratnicki A. Grochot-Przeczek A. Taha H. Kotlinowski J. Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice Free Radic. Biol. Med. 2011 51 1717 1726 10.1016/j.freeradbiomed.2011.07.025 21867749

상세보기
45. Jia B.C. Guan J. Dai X.P. Yang J. Wang J.J. Liu X.P. Expression and clinical significance of Nrf2 and HO-1 in oral squamous cell carcinoma J. Oral Sci. Res. 2017 33 207 210
46. Calatayud S. Ramírez M.C. Sanz M.J. Moreno L. Hernández C. Bosch J. Piqué J.M. Esplugues J.V. Gastric mucosal resistance to acute injury in experimental portal hypertension Br. J. Pharmacol. 2001 132 209 317 10.1038/sj.bjp.0703785 11156591

상세보기
47. Shore R. Björne H. Omoto Y. Siemiatkowska A. Gustafsson J.A. Lindblad M. Holm L. Sex differences and effects of oestrogen in rat gastric mucosal defence World J. Gastroenterol. 2017 23 426 436 10.3748/wjg.v23.i3.426 28210078

상세보기

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Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice 원문보기

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