[논문]Molecular immune pathogenesis and diagnosis of COVID-19

Li, Xiaowei; Geng, Manman; Peng, Yizhao; Meng, Liesu; Lu, Shemin

doi:10.1016/j.jpha.2020.03.001

Molecular immune pathogenesis and diagnosis of COVID-19 원문보기

Journal of pharmaceutical analysis = 藥物分析學報 (英文版), v.10 no.2, 2020년, pp.102 - 108

Li, Xiaowei (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center) , Geng, Manman (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center) , Peng, Yizhao (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center) , Meng, Liesu (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center) , Lu, Shemin (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center)

Abstract ▼ AI-Helper

Abstract Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. Highlights The highly pathogenic SARS-CoV-2 appearing in December 2019 can cause COVID-19 and even death in infected persons. Coronavirus infections led to the damage of lung, while imbalanced and excessive immune responses may cause pneumonia. RT-PCR and CT scans are significant for the diagnosis of SARS-CoV-2 infection, and drugs and vaccines against SARS-CoV-2 are being developed. Graphical abstract [DISPLAY OMISSION]

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Molecular immune pathogenesis and diagnosis of COVID-19 원문보기

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