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[해외논문] β-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53-MDM2 Interaction in Colorectal Cancer

Journal of agricultural and food chemistry, v.68 no.12, 2020년, pp.3850 - 3858  

Wang, Ziyuan (Department of Pathology, Shuguang Hospital , Shanghai University of Traditional Chinese Medicine , 528 Zhangheng Road , Shanghai 201203 , China) ,  Zhan, Yueping (Interventional Cancer Institute of Integrative Medicine, Putuo Hospital , Shanghai University of Traditional Chinese Medicine , 164 Lanxi Road , Shanghai 200062 , China) ,  Xu, Jian (Interventional Cancer Institute of Integrative Medicine, Putuo Hospital , Shanghai University of Traditional Chinese Medicine , 164 Lanxi Road , Shanghai 200062 , China) ,  Wang, Yang (Department of Pathology, Shuguang Hospital , Shanghai University of Traditional Chinese Medicine , 528 Zhangheng Road , Shanghai 201203 , China) ,  Sun, Mingyu (Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital , Shanghai University of Traditional Chinese Medicine , 528 Zhangheng Road , Shanghai 201203 , China) ,  Chen, Jia (Department of Pathology, Shuguang Hospita) ,  Liang, Tingyu ,  Wu, Lili ,  Xu, Ke

Abstract AI-Helper 아이콘AI-Helper

Phytosterols are widely present in vegetable oils, nuts, cereal products, fruits, and berries. Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug resistance in cancer therapy. Here, we demonstrated that β-sitosterol, the most common dietary phytosterol, r...

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