초록 ▼

The present invention relates to the use of compositions comprising receptor ligands obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with lactic acid bacteria to obtain a fermented food or feed material that comprises ligands of specific a

The present invention relates to the use of compositions comprising receptor ligands obtainable by a process comprising fermenting a food material, comprising animal milk or vegetable proteins, with lactic acid bacteria to obtain a fermented food or feed material that comprises ligands of specific adrenoreceptors and/or serotonin receptors. The fermented food or feed material is useful e.g. for reducing and/or stabilizing heart rate in a mammal. It may furthermore be used for treatment and/or relief of erectile dysfunctions and for treatment and/or relief of benign prostate hypertrophy (BPH), in a mammal.

대표청구항 ▼

1. A method of treating or preventing benign prostate hypertrophy and/or erectile dysfunction in a mammal, comprising administering to said mammal a composition (A) that comprises a ligand of an adrenergic or a serotonin receptor and (B) that is prepared by fermenting, with at least one lactic acid

1. A method of treating or preventing benign prostate hypertrophy and/or erectile dysfunction in a mammal, comprising administering to said mammal a composition (A) that comprises a ligand of an adrenergic or a serotonin receptor and (B) that is prepared by fermenting, with at least one lactic acid bacterial strain, a food material comprised of animal milk or vegetable proteins, wherein said lactic acid bacterial strain is a Lactobacillus helveticus strain. 2. The method according to claim 1, wherein said receptor is selected from the group of receptors comprising alpha-adrenergic receptors, beta-adrenergic receptors and serotonin receptors. 3. The method according to claim 2, wherein said receptor is selected from the group of receptors comprising the alpha1A-, the alpha1B-, the alpha2A(h)-, the alpha2B(h)-, the alpha2C(h)-, the beta1(h)-, the beta2(h)- and the beta3(h)-adrenergic receptor and serotonin receptors. 4. The method according to claim 3, wherein said receptor is selected from the group of receptors comprising the alpha2A(h)-, the apha2B(h)- and the beta2(h)-adrenergic receptor. 5. The method according to claim 1, wherein said ligand of said receptor has the characteristics of being an antagonist of the receptor. 6. The method according to claim 1, wherein the composition is a food or feed product. 7. The method according to claim 1, wherein said administration reduces the heart rate of said mammal. 8. The method according to claim 1, wherein said composition further comprises at least one ligand of the GABA receptor. 9. The method according to claim 8, wherein said ligand to the GABA receptor is GABA produced by GABA-producing microorganisms included amongst microorganisms used to perform said fermentation. 10. The method according to claim 1, wherein the composition is fermented using a combination of at least two lactic acid bacteria.