초록 ▼

1차년도('98)
- 연구목표: 학습검사, 5-HT 함량 및 활성도 분석기술 확립
- 연구내용: 스트레스 노출법 확립 학습검사 분석기술 확립 5-HT 함량 및 활성도 분석기술 확립
2차년도('99)
- 연구목표: 스트레스에 의한 학습기능 변동에 관련된 5-HT계 변동규명
- 연구내용: 생애초기 스트레스 노출 성숙 후 학습기능 검색 동반된 신경화학적 변동 검사 행동과 내재된 생물학적 변동간의 상관관계 추구
3차년도('00)
- 연구목표: 5-HT계 변동으로 인한 학습기능 변동 규명

1차년도('98)
- 연구목표: 학습검사, 5-HT 함량 및 활성도 분석기술 확립
- 연구내용: 스트레스 노출법 확립 학습검사 분석기술 확립 5-HT 함량 및 활성도 분석기술 확립
2차년도('99)
- 연구목표: 스트레스에 의한 학습기능 변동에 관련된 5-HT계 변동규명
- 연구내용: 생애초기 스트레스 노출 성숙 후 학습기능 검색 동반된 신경화학적 변동 검사 행동과 내재된 생물학적 변동간의 상관관계 추구
3차년도('00)
- 연구목표: 5-HT계 변동으로 인한 학습기능 변동 규명
- 연구내용: 생애초기 인위적 5-HT계 변동 학습기능 검색 행동과 내재된 생물학적 변동간의 상관관계 추구

Abstract ▼

Learning and memory is one of the most important brain functions because it expresses the plasticity of brain. The fundamental phenomena and mechanisms of learning and memory are still in debate although many reports have addressed these issues. Long-term potentiation and long-term depression have b

Learning and memory is one of the most important brain functions because it expresses the plasticity of brain. The fundamental phenomena and mechanisms of learning and memory are still in debate although many reports have addressed these issues. Long-term potentiation and long-term depression have been used to explain the molecular mechanisms of learning and memory. However, studies concerning a specific synapse(s) can not explain the comprehensive phenomena of learning and memory since learning and memory is expressed as a goal-directed behavior leer the adjustment of the organism to the new environment. Therefore, a new theoretical framework is needed to solve the problems.
Life consists of a continuous response upon environmental stimulation. Environmental stimuli, stress, evokers coping response of an organism. We recognize learning and memory as a stress response of an organism to the environmental stimulation. The controllable stress strengthens the existing neuronal network while the uncontrollable stress destroys the network. We think the strengthening of the neuronal network is expressed by the learning. Therefore, studies of the falters influencing learning and memory should begin at the study of stress especially early in life when the plasticity of brawn is the highest throughout life.
This study aimed to develop a method of enhancing learning and memory on the basis of determining the direction of response which is evoked by environmental stimulation. The direction of the response should be dependent upon the previous response of the organism. Therefore, we examined the role of the previous response on the facing stressor-stress response. Especially, the role of 5-hydroxytryptamine(5-HT) system was examined in relation to the stress response. This study provided a basis to develop methods of enhancing learning and memory, and a theoretical background to develop an artificial brain.
This study had three specific aims.
1 To establish the method of analysis of the learning behavior and of the 5-hydroxytryptamine system.
2. To examine changes of the 5-hydroxytryptamine system in stress-related alteration of the learning behavior
3. To examine altered learning behavior induced by changed 5-hydroytryptamine system.
We established the autoshaped learning test, the method of exposing foot shock early in life and tole methods of examining 5-hydroxytryptamine system. We found that early life stress results In altered teaming behavior and hippocampal corticosteroid receptors at adulthood. We also found that differences in the previous experiences determine the nature of stress response occurring later. Moreover, the response trait to the environmental stimuli plays an important role for determining the performance level of the conditioned behavior at adulthood. Finally, altered 5-hydroxytryptamine activity of tole brain resulted in altered learning performance, suggesting a possibility to modify ability of learning and memory by manipulating 5-hydroxytryptamine system.
The experimental results using this model, which deal with the fundamental issues of the expression of brain functions, will contribute to the development of learning-enhancing methods and of the artificial brain eventually.

목차 Contents

• 제 1 장 서론...11
• 제1절. 연구개발의 목적 및 필요성...11
• 제2절. 연구범위...12
• 제 2 장 국내외 기술개발 현황...14
• 제1절. 기술개발 현황...14
• 제2절. 현기술상태의 취약성과 본연구진의 가설...15
• 제 3 장 연구개발수행 내용 및 결과...17
• 제1절. 학습검사, 5-HT 함량 및 활성도 분석기술 확립...17
• 제2절. 스트레스에 의한 학습기능 변동에 관련된 5-HT계 변동 규명...19
• 제3절. 5-HT계 변동으로 인한 학습기능 변동 규명...21
• 제4절. 종합결론 및 연구개발성과...22
• 제 4 장 연구개발목표 달성도 및 대외기여도...35
• 제 5 장 연구개발결과의 활용계획...36