초록 ▼

○ 다기관 임상연구 협력 네트워크 관리 및 확충
- 전국 한방병원 및 한의원으로 구성된 한방기관 및 코호트, 생리체, 국외 연구기관을 포괄하는 29개 다기관 임상연구 협력 네트워크를 확충함.
○ 체질 증례 구축
- 체질 확진자 증례 3701건, 지역 코호트와 연계한 증례 7,752건, 생리체 증례 626건, 일반인 증례 2,257건, 국외 증례 263건 수집함.
- 3명 이상의 직계가족이나 형제를 포함한 총 280가계 1,319명의 소가계 증례 및 3대 40명 이상으로 구성된 2개의 대가계 148명의 증례를 수

○ 다기관 임상연구 협력 네트워크 관리 및 확충
- 전국 한방병원 및 한의원으로 구성된 한방기관 및 코호트, 생리체, 국외 연구기관을 포괄하는 29개 다기관 임상연구 협력 네트워크를 확충함.
○ 체질 증례 구축
- 체질 확진자 증례 3701건, 지역 코호트와 연계한 증례 7,752건, 생리체 증례 626건, 일반인 증례 2,257건, 국외 증례 263건 수집함.
- 3명 이상의 직계가족이나 형제를 포함한 총 280가계 1,319명의 소가계 증례 및 3대 40명 이상으로 구성된 2개의 대가계 148명의 증례를 수집함.
○ 체질정보은행 구축 현황
- 다기관으로부터 대상자의 안면, 체형, 설문, 약리, 진단소견 등 체질임상정보, 계측정보 및 혈액검사, DNA 등 생물학적 정보를 수집함.
- 의약품 임상시험 관리기준(KGCP) 제28조 자료의 처리에 근거하여 전자자료 수집 및 처리시스템을 재구축함.
○ 체질-질병 상관성 연구
- 두 개 한방병원에서 뇌졸젒 환자 50례, 근위축성측삭경화증 환자 28례의 체질임상정보 및 생물학적 정보를 수집하여 체질과 질환위험인자와의 상관관계를 밝힐 수 있는 기초 데이터를 확보함.
(출처 : 보고서 요약서 4P)

Abstract ▼

Chapter 4. Results of research and development
I. Management and expansion of the clinical research network
(1) Oriental medicine hospital and oriental medicine clinic
- Oriental medicine cooperative network consisting of nationwide oriental medicine hospital(13) and clinic (11) is managed.

Chapter 4. Results of research and development
I. Management and expansion of the clinical research network
(1) Oriental medicine hospital and oriental medicine clinic
- Oriental medicine cooperative network consisting of nationwide oriental medicine hospital(13) and clinic (11) is managed. The constitutional clinical data and biological data for the confirmed cases are collecting through the network.
(2) Cohort research Center
- For verifying constitutional diagnosis tool and the epidemiological study about Sasang constitution and disease, the joint research was conducted with a regional cohort of National Institute of Health. The existing diagnosis data and additional clinical data, measured data, and biological data were collected for Ansan and Asan Cohort medical examination subjects of Korea and Aju University respectively.
(3) Physiome Research center
- To establish the foundation for interpreting Sasang constitutional phenomenon physiologically, Ulsan medical college and Seoul Asan hospital were cooperatively conducting the research of physiome according to constitutions. The index of psychology related to variety of energy metabolism for ordinary people who are healthy was collected with the clinical data and measured data including constitutional characteristics.
(4) Overseas research center
- To build up the international constitutional data collaborating with overseas research center, Tohoku medical college in Japan and Joui hospital in China were selected as the overseas cooperation research center. Clinical data and measured data about Japanese and Chinese were collected.

II. Expansion of Clinical Constitution data for subjects
1. Establishment of Korea Constitutional Multicenter Bank, KCMB
A. Establishment of KCMB
- KCMB was constructed participating in oriental medicine hospitals and clinics, cohort research centers, physiome research institution and overseas research centers. And KCMB built up the database by collecting clinical constitution data, measured data, biological data about the confirmed case, cohort case, physiome case, family case, ordinary people's case and overseas case(Japan, China).
B. The current status on the construction of KCMB
- The total number of cases which have been collected in KCMB is 14,927 cases. The cases consist of 3,701 for the constitution confirmed cases, 7,752 cohort cases, 626 physiome cases, 2,257 ordinary people's cases, 263 overseas cases, and 328 family cases. (From November, 2006 to May 6th, 2012).
2. The systematic data management of KCMB
- The standard operating procedure was developed for the data management of KCMB, accordingly the systematic and standardized data management procedure such as data entry, data error checking, validity test and so on has been conducted.
3. The data utilization of KCMB
A. The procedure of the KCMB data utilization
- The procedure for the data utilization has been prepared and an examination committee has been running. Also 58 cases were provided to inside and outside institutions.
B. Publishing a white paper for the cases of KCMB
- The white paper was published in April, 2012, and statistically arranged and analysed about 10,000 data which domestic oriental · western medication clinics and overseas research centers had collaboratively collected(The collection period: November, 2006~August, 2011)(ISBN: 978-89-5970-125-4).

III. Analysis and a follow-up survey for clinical constitution data of a family
1. Collecting the clinical data for a family
A. Collecting the cases of a family study and a follow-up survey.
- Cooperation institutions collected the family information about three generations on the basis of the subject(first generation: parents, second generation: the subject, third generation: children), who are related to each other by blood, and a follow-up survey was conducted.
- Through the follow-up survey, the total 462 people which constitute 53 families as parents-the subject-children were observed.
B. Upgrading constitutional diagnosis in two large families
- Three constitutional specialists classified large family A and B class which are in accord with the constitutional diagnosis. Excepting the cases, they reinvestigated and adjusted 39 cases of C, D and F class which are not in accord with the constitutional diagnosis. And finally the family constitution class was upgraded as 87 for A class, 45 for B class.
C. The result on the family constitution heredity analysis
- According to the result on heredity analysis of family data, sons' personality and body shape related to obesity generally correlate the maternal heredity, and the shape of the face is related to the paternal side. For daughters' case, their personality is related to the paternal side, but their body shape and appearance are related to the maternal line.

IV. Study on the correlation of Constitution-Disease
1. The study on the correlation between constitution and disease
A. The clinical study on the correlation of constitution-Stroke
(1) The purpose of the study is to prove the hypothesis that there exist differences in physiological pathology by constitution and differences in prevalence rates of disease by constitution. It was conducted by investigating the correlation between apoplexy and each constitution considering other major risk factors .
(2) For weight and weight of skeletal muscle, Taeeumin was much heavier than soeumin. For LDL(Low Density Lipoprotein), the result of Soyangin was much higher than Taeeumin's and Soeumin's.
(3) On the analysis according to the types of apoplexy, any item of cerebral hemorrhage(N=10) didn't show a difference by constitution. According to the result of cerebral infraction, the weight of Taeeumin and Soyangin was much heavier than Soeumin, and for the weight of skeletal muscle and BMI, Taeeumin was much higher than Soeumin. For total cholesterol and LDL, the result from Soyangin was much higher than the one from Taeeumin and Soeumin, and besides, the rate of non-smoker in Soeumin was higher than any other constitutions. B. The analysis of the constitutional factors in Amyotrophic Lateral Sclerosis(ALS) patients
(1) The purpose of the analysis is to prepare the basis of the hypothesis that the constitution of Taeyangin is correlated to ALS. For the analysis, body constitution specialists collected the constitutional factors such as demographic information, face and voice characteristics and physical shape about ALS patients, and then investigated the constitutional diagnosis with them.
(2) The number of the cases which we originally aimed was 30, but finally 28 cases were collected due to some difficulties to collect rare disease case. Male cases were 21, females were 7 among the total 28 cases. Taeemins were 10 people, Souemins 6, Soyangins 9, and Taeyangins 3 according to constitution. The rate of soyangin and taeyangin in the group was larger than the one in general population group.
(3) Physical shape
- Other 585 cases which consisted of people who were similar ages of 28 cases were compared with ALS patient group ALS. From the result, we discovered that the value of part 1, 2, 6 and 8 showed significant difference in measured value of part 8 . In the measured value of part 6, the value of part 3 and 5 were indicated differently. Among the parts except part 8-8 and 5-5, which indicated significant difference, all the cases of ALS had more higher value than the comparison group. It shows that the rate of physical development of the upper body in ALS group is larger than the comparison group. And also the result can explain that there are more Taeyangins and Soyangins in ALS group than in the comparison group.
(출처 : SUMMARY 17P)

목차 Contents

• 표지 ... 1제 출 문 ... 2보고서 요약서 ... 4요 약 문 ... 5SUMMARY ... 16CONTENTS ... 28목차 ... 29제 1 장 연구개발과제의 개요 ... 30 1. 연구개발의 목적 ... 30 2. 연구개발의 필요성 ... 30 3. 연구개발의 범위 ... 31제 2 장 국내외 기술개발 현황 ... 32 1. 지금까지의 연구개발 실적 ... 32 2. 현기술상태의 취약성 ... 33 3. 앞으로의 전망 ... 33제 3 장 연구개발 수행내용 및 결과 ... 34 제 1 절 임상연구 네트워크 관리 및 확충 ... 34 제 2 절 피험자 체질임상정보 확충 ... 92 제 3 절 체질 가계 체질임상정보 분석 및 추적조사 ... 125 제 4 절 체질-질병 상관성 연구 시행 ... 141 제 5 절 체질정보 은행 확충 및 eCRF 개선 ... 155제 4 장 목표달성도 및 관련분야에의 기여도 ... 172제 5 장 연구개발결과의 활용계획 ... 173 1. 추가연구의 필요성 ... 173 2. 타 연구에의 응용 ... 173제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 174제 7 장 연구시설·장비 현황 ... 175제 8 장 참고문헌 ... 176끝페이지 ... 178