The aromatic medicinal plant Angelica dahurica (Umbelliferae) is a perennial herb found abundantly in Korea, China and Russia. The root of this species has been used in Korea as a traditional folk medicine to treat headache, toothache, aching eyes, abdominal pain, hysteria, bleeding, menstrual disor...
The aromatic medicinal plant Angelica dahurica (Umbelliferae) is a perennial herb found abundantly in Korea, China and Russia. The root of this species has been used in Korea as a traditional folk medicine to treat headache, toothache, aching eyes, abdominal pain, hysteria, bleeding, menstrual disorder and neuralgia. The aim of this study is to investigate the transformation of constituents and bioactivities of A. dahurica root by fermentation. The author investigated the anti-oxidation, anti-inflammatory effects of A. dahurica root and fermented A. dahurica root.
1. Using HPLC method, the author investigated that isoimperatorin, imperatorin, oxypeucedanin in fermented A. dahurica root were decreased, oxypeucedanin hydrate was increased 14 folds. Futhermore, the structures of isoimperatorin and imperatorin were determined.
2. A. dahurica root and fermented A. dahurica root have shown anti-oxidant effects using DPPH assay, especially in the fat-soluble fraction.
3. A. dahurica root and fermented A. dahurica root have not affect the cell viability measured by MTS assay.
4. The productions of nitrite were inhibited 29% and 55% by A. dahurica root and fermented A. dahurica root.
5. The COX-2 expressions were inhibited by every fractions of A. dahurica root and fermented A. dahurica root, and fat-soluble fraction was most effective.
6. The iNOS expressions were inhibited by every fractions of A. dahurica root and fermented A. dahurica root, and the fat-soluble fraction was most effective.
7. Using antibody array, every fractions of A. dahurica root and fermented A. dahurica root have shown to inhibit the productions of IL-1β, IL-2, IL-6, and TNF-α. The production of IL-3 was inhibited 83% by fermented A. dahurica root, but was not inhibited by A. dahurica root. The production of IL-4 was inhibited by A. dahurica root, but was not inhibited by fermented A. dahurica root.
In conclusion, the author investigated the constituents of A. dahurica root were transformed by fermentation, and the bioactivities were changed by fermentation. The anti-inflammatory effect was most effective in the fat-soluble fraction of fermented A. dahurica root. The author suggests that this study will be a good reference for using fermented oriental medicine, and developing new medicine.
The aromatic medicinal plant Angelica dahurica (Umbelliferae) is a perennial herb found abundantly in Korea, China and Russia. The root of this species has been used in Korea as a traditional folk medicine to treat headache, toothache, aching eyes, abdominal pain, hysteria, bleeding, menstrual disorder and neuralgia. The aim of this study is to investigate the transformation of constituents and bioactivities of A. dahurica root by fermentation. The author investigated the anti-oxidation, anti-inflammatory effects of A. dahurica root and fermented A. dahurica root.
1. Using HPLC method, the author investigated that isoimperatorin, imperatorin, oxypeucedanin in fermented A. dahurica root were decreased, oxypeucedanin hydrate was increased 14 folds. Futhermore, the structures of isoimperatorin and imperatorin were determined.
2. A. dahurica root and fermented A. dahurica root have shown anti-oxidant effects using DPPH assay, especially in the fat-soluble fraction.
3. A. dahurica root and fermented A. dahurica root have not affect the cell viability measured by MTS assay.
4. The productions of nitrite were inhibited 29% and 55% by A. dahurica root and fermented A. dahurica root.
5. The COX-2 expressions were inhibited by every fractions of A. dahurica root and fermented A. dahurica root, and fat-soluble fraction was most effective.
6. The iNOS expressions were inhibited by every fractions of A. dahurica root and fermented A. dahurica root, and the fat-soluble fraction was most effective.
7. Using antibody array, every fractions of A. dahurica root and fermented A. dahurica root have shown to inhibit the productions of IL-1β, IL-2, IL-6, and TNF-α. The production of IL-3 was inhibited 83% by fermented A. dahurica root, but was not inhibited by A. dahurica root. The production of IL-4 was inhibited by A. dahurica root, but was not inhibited by fermented A. dahurica root.
In conclusion, the author investigated the constituents of A. dahurica root were transformed by fermentation, and the bioactivities were changed by fermentation. The anti-inflammatory effect was most effective in the fat-soluble fraction of fermented A. dahurica root. The author suggests that this study will be a good reference for using fermented oriental medicine, and developing new medicine.
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