당뇨병(diabetes mellitus)은 전 세계적으로 문제가 되고 있는 대사성 만성질환으로 현재 한국인 사망요인 중 4위를 차지하는 질병이다. 당뇨병은 인슐린의 분비 저하 또는 기능의 결함으로 당질, 단백질, 지질대사의 이상과 함께 고혈당을 동반하는 질환이다. 지속적으로 이상적인 혈당을 유지하여 당뇨병성 합병증을 예방하고 지연하는 것이 가장 중요한 당뇨병 치료목표이다. 당뇨병을 치료하기 위해 ...
당뇨병(diabetes mellitus)은 전 세계적으로 문제가 되고 있는 대사성 만성질환으로 현재 한국인 사망요인 중 4위를 차지하는 질병이다. 당뇨병은 인슐린의 분비 저하 또는 기능의 결함으로 당질, 단백질, 지질대사의 이상과 함께 고혈당을 동반하는 질환이다. 지속적으로 이상적인 혈당을 유지하여 당뇨병성 합병증을 예방하고 지연하는 것이 가장 중요한 당뇨병 치료목표이다. 당뇨병을 치료하기 위해 식사요법, 운동요법, 약물요법이 실시되고 있으나, 약물요법을 장기간 실시할 경우 구토, 복부팽만감 등의 부작용이 나타날 수 있어, 천연물로부터 부작용을 감소시키고 고혈당을 개선시킬 수 있는 소재에 대한 연구가 활발히 진행 중이다. 민들레에는 flavonoid 성분이 많이 함유되어 있어 지질 농도저하, 혈당강하에 큰 효과가 있다고 보고되어 당뇨병에 효능이 있을 것으로 기대되고 있다. 이에 본 연구에서는 제 2형 당뇨동물모델을 이용하여 민들레의 당뇨병 개선효과 및 당뇨 합병증 예방 효과를 규명하고자 하였다.
당뇨병(diabetes mellitus)은 전 세계적으로 문제가 되고 있는 대사성 만성질환으로 현재 한국인 사망요인 중 4위를 차지하는 질병이다. 당뇨병은 인슐린의 분비 저하 또는 기능의 결함으로 당질, 단백질, 지질대사의 이상과 함께 고혈당을 동반하는 질환이다. 지속적으로 이상적인 혈당을 유지하여 당뇨병성 합병증을 예방하고 지연하는 것이 가장 중요한 당뇨병 치료목표이다. 당뇨병을 치료하기 위해 식사요법, 운동요법, 약물요법이 실시되고 있으나, 약물요법을 장기간 실시할 경우 구토, 복부팽만감 등의 부작용이 나타날 수 있어, 천연물로부터 부작용을 감소시키고 고혈당을 개선시킬 수 있는 소재에 대한 연구가 활발히 진행 중이다. 민들레에는 flavonoid 성분이 많이 함유되어 있어 지질 농도저하, 혈당강하에 큰 효과가 있다고 보고되어 당뇨병에 효능이 있을 것으로 기대되고 있다. 이에 본 연구에서는 제 2형 당뇨 동물모델을 이용하여 민들레의 당뇨병 개선효과 및 당뇨 합병증 예방 효과를 규명하고자 하였다.
Diabetes mellitus is the fourth leading cause of death among Koreans. Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and/or defects of insu...
Diabetes mellitus is the fourth leading cause of death among Koreans. Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and/or defects of insulin action. To control blood glucose levels as close to normal is one of the major goals for the treatment of diabetes mellitus. To treat diabetes medical, diet and physical therapies are used. However, chronic use of oral hypoglycemic agent could result in side effects such as flatulence, abdominal cramping, vomiting so that their use may be limited. Therefore, the numerous research is underway to develop hypoglycemic agents from natural sources. The purpose of this study is to elucidate the antidiabetic effects of Taraxacum officinale (TO) in vitro and in animal models of type 2 diabetes. Inhibitory activities of methanol extract of TO against yeast alpha-glucosidase activity and pancreatic lipase were measured in vitro. Alhpa-glucosidase inhibitory activity of TO was 31.5% at the concentration of 0.5 mg/mL. Pancreatic lipase inhibitory activity of TO was 86.1% at the concentration of 0.25 mg/mL. Type 2 diabetic mice (db/db mice, C57BL/Ks, n=14) were fed AIN-93G diet or diet containing 1% TO methanol extract for 6 wk after 1 wk of adaptation period. Fasting plasma glucose level of TO group was significantly lower than those of control group (p<0.05). Glycated hemoglobin (HbA1c) level tended to decrease compared with control group. Plasma triglyceride (p<0.05) and total cholesterol levels (p<0.01) of TO group were significantly lower than control group. HDL-cholesterol level of TO group was significantly increased compared with control group (p<0.05). Hepatic thiobarbituric acid reactive substances (TBARS) level of TO group was significantly lower than control group (p<0.05). Feeding of TO significantly increased hepatic superoxide dismutase (SOD) activity compared with control group (p<0.01). However, there was no significant difference in catalase activites between TO and control groups. Chronic consumption of TO did not significantly influence BUN, creatinine, GOT and GPT. In conclusion, TO exerted hypoglycemic and hypolipidemic effects in animal model of type 2 diabetes mellitus. Thus, TO could be beneficial in the treatment of type 2 diabetes and in the prevention of cardiovascular complications.
Diabetes mellitus is the fourth leading cause of death among Koreans. Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and/or defects of insulin action. To control blood glucose levels as close to normal is one of the major goals for the treatment of diabetes mellitus. To treat diabetes medical, diet and physical therapies are used. However, chronic use of oral hypoglycemic agent could result in side effects such as flatulence, abdominal cramping, vomiting so that their use may be limited. Therefore, the numerous research is underway to develop hypoglycemic agents from natural sources. The purpose of this study is to elucidate the antidiabetic effects of Taraxacum officinale (TO) in vitro and in animal models of type 2 diabetes. Inhibitory activities of methanol extract of TO against yeast alpha-glucosidase activity and pancreatic lipase were measured in vitro. Alhpa-glucosidase inhibitory activity of TO was 31.5% at the concentration of 0.5 mg/mL. Pancreatic lipase inhibitory activity of TO was 86.1% at the concentration of 0.25 mg/mL. Type 2 diabetic mice (db/db mice, C57BL/Ks, n=14) were fed AIN-93G diet or diet containing 1% TO methanol extract for 6 wk after 1 wk of adaptation period. Fasting plasma glucose level of TO group was significantly lower than those of control group (p<0.05). Glycated hemoglobin (HbA1c) level tended to decrease compared with control group. Plasma triglyceride (p<0.05) and total cholesterol levels (p<0.01) of TO group were significantly lower than control group. HDL-cholesterol level of TO group was significantly increased compared with control group (p<0.05). Hepatic thiobarbituric acid reactive substances (TBARS) level of TO group was significantly lower than control group (p<0.05). Feeding of TO significantly increased hepatic superoxide dismutase (SOD) activity compared with control group (p<0.01). However, there was no significant difference in catalase activites between TO and control groups. Chronic consumption of TO did not significantly influence BUN, creatinine, GOT and GPT. In conclusion, TO exerted hypoglycemic and hypolipidemic effects in animal model of type 2 diabetes mellitus. Thus, TO could be beneficial in the treatment of type 2 diabetes and in the prevention of cardiovascular complications.
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