Hwangryunhaedok-tang (HRHDT) is one of the well-known prescription herbal drugs of oriental herbal medicine, which has been widely used for the treatment of various bacterial and inflammatory diseases. This study was conducted in order to develop the tablet formulations of HRHDT and compare its effi...
Hwangryunhaedok-tang (HRHDT) is one of the well-known prescription herbal drugs of oriental herbal medicine, which has been widely used for the treatment of various bacterial and inflammatory diseases. This study was conducted in order to develop the tablet formulations of HRHDT and compare its efficacy with the other commercial formulations. Corresponding herbal medicines comprising of HRHDT were extracted with water for 3 hr at 95~100℃ and then vacuum dried. The yield % of HRHDT obtained from Scutellaria Root, Coptis Rhizome, Phellodendron Bark and Gardenia Fruit extracts were approximately 28.0, 11.2, 13.5 and 21.6 % respectively. Subsequently, some pharmaceutical excipients such as microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, etc were used to prepare the HRHDT tablets. Furthermore, we investigated the anti-inflammatory and antioxidative abilities of two different commercial HRHDT granules (HJP-1 and HJP-2) and were compared with that of the formulated HRHDT tablets. Our results demonstrated that HRHDT tablets showed more anti-inflammatory and antioxidative effects than HJP-1, HJP-2. Moreover, it showed more superior effects in terms of dose, usability and stability than the granules. Hence, we concluded that in order to improve the quality and efficacy of the oriental herbal medicine, it is necessary to develop appropriate methods and establish standardized techniques for the development of good formulations.The aim of this study was to develop a hydrophilic matrix based controlled release gastroretentive drug delivery system for samchulkunbi-tang (ST), a traditional Korean herbal medicine widely used for treatment of chronic gastritis and gastric ulcers. Effervescent floating gastroretentive drug delivery system of ST was prepared by non-aqueous wet granulation method. Hydroxypropyl methylcellulose 2208 (100,000cps) was used as the hydrophilic polymer, while the combination of sodium bicarbonate (NaHCO3) and citric acid was used as the gas-generating agents. Formulation optimization was done by altering the amount of polymer and floating aid, keeping the tablet weight constant. Tablet properties including floating lag time(FLT), total floating time(TFT) and swelling index(SI) were measured to determine the optimized formulation. Scanning electron microscopy(SEM) analysis revealed the surface morphology of the swollent ablet with concomitant gasbubbles. Optimized formulation showed satisfactory controlled in vitro drug release for more than 8 h with excellent buoyancy properties (FLT of 30 sec, TFT >12 h). Therefore, the developed formulation of ST in the form of a floating tablet would provide effective gastroprotection and can be a promising approach to delivery of the drug in the upper gastrointestinal tract.
Hwangryunhaedok-tang (HRHDT) is one of the well-known prescription herbal drugs of oriental herbal medicine, which has been widely used for the treatment of various bacterial and inflammatory diseases. This study was conducted in order to develop the tablet formulations of HRHDT and compare its efficacy with the other commercial formulations. Corresponding herbal medicines comprising of HRHDT were extracted with water for 3 hr at 95~100℃ and then vacuum dried. The yield % of HRHDT obtained from Scutellaria Root, Coptis Rhizome, Phellodendron Bark and Gardenia Fruit extracts were approximately 28.0, 11.2, 13.5 and 21.6 % respectively. Subsequently, some pharmaceutical excipients such as microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, etc were used to prepare the HRHDT tablets. Furthermore, we investigated the anti-inflammatory and antioxidative abilities of two different commercial HRHDT granules (HJP-1 and HJP-2) and were compared with that of the formulated HRHDT tablets. Our results demonstrated that HRHDT tablets showed more anti-inflammatory and antioxidative effects than HJP-1, HJP-2. Moreover, it showed more superior effects in terms of dose, usability and stability than the granules. Hence, we concluded that in order to improve the quality and efficacy of the oriental herbal medicine, it is necessary to develop appropriate methods and establish standardized techniques for the development of good formulations.The aim of this study was to develop a hydrophilic matrix based controlled release gastroretentive drug delivery system for samchulkunbi-tang (ST), a traditional Korean herbal medicine widely used for treatment of chronic gastritis and gastric ulcers. Effervescent floating gastroretentive drug delivery system of ST was prepared by non-aqueous wet granulation method. Hydroxypropyl methylcellulose 2208 (100,000cps) was used as the hydrophilic polymer, while the combination of sodium bicarbonate (NaHCO3) and citric acid was used as the gas-generating agents. Formulation optimization was done by altering the amount of polymer and floating aid, keeping the tablet weight constant. Tablet properties including floating lag time(FLT), total floating time(TFT) and swelling index(SI) were measured to determine the optimized formulation. Scanning electron microscopy(SEM) analysis revealed the surface morphology of the swollent ablet with concomitant gasbubbles. Optimized formulation showed satisfactory controlled in vitro drug release for more than 8 h with excellent buoyancy properties (FLT of 30 sec, TFT >12 h). Therefore, the developed formulation of ST in the form of a floating tablet would provide effective gastroprotection and can be a promising approach to delivery of the drug in the upper gastrointestinal tract.
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