[논문]체중조절 기전과 항비만 기능성물질

안인숙; 박건영; 도명술

doi:10.3746/jkfn.2007.36.4.503

[국내논문] 체중조절 기전과 항비만 기능성물질
Weight Control Mechanisms and Antiobesity Functional Agents 원문보기

한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, v.36 no.4, 2007년, pp.503 - 513

안인숙 (한동대학교 생명식품과학부) , 박건영 (부산대학교 식품영양학과) , 도명술 (한동대학교 생명식품과학부)

Abstract ▼ AI-Helper

The obese population has been increasing worldwide and obesity has become one of the socioeconomic problems. Obesity raises more concerns as more studies regarding its direct and indirect relativity to several diseases such as type II diabetes, hypertension, etc. are published. Since leptin, an important signal in the chronic control of food intake and energy expenditure, was discovered in 1994, there has been a great accumulation of knowledge on fighting obesity by facilitating pharmacological and nutritional strategies on the molecular level of the body weight control system. In particular, evidences are accumulating that particular food components affect our physiological function and gene expressions which are associated with body weight control. In this study, we review the four mechanisms for weight control and antiobesity functional agents such as HCA, L-carnitine, CLA, chitosan, calcium supplements capsaicin contained in red pepper, and oriental herbal mixture. We also describe about the efficacy and working mechanism of these functional agents on the basis of antiobesity mechanisms.

주제어

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문제 정의

본 총설에서는 비 만을 해소하고 적절한 체중을 유지하기 위한 체중조절 전략을 4가지(식욕의 조절, 지방의 소화 및 흡수 방해, 적응성 열발생을 통한 에너지 소비의 증가, 지질대사의 조절)로 정리하여 그 기전을 정리하고 이 전략에 따라 현재까지 효능이 입증되었거나 연구 중에 있는 항비 만 기능성 물질들을 소개하였다.
이 총설에서는 체중조절을 위하여 식욕조절에 관여하는 신호들과 작용 기작, 지방의 소화 및 흡수 과정과 이 과정 에 관여하는 단백질들, 적응성 열발생에 의한 에너지 소모, 지질대사(지방의 생성과 분해)에 관여하는 효소들과 전사인자들을 살펴보고 여기에 영향을 미치는 기능성 물질들을 정리해 보았다. 이들은 대부분 우리 식생활에 익숙한 것들로서 비교적 연구가 많이 되었으나 아직까지도 그 작용 기전이나 효과 등을 밝히는데 있어서는 부족한 실정이다.

성능/효과

녹차는 콜레스테롤 저하 효능이 있으며 녹차를 함유한 식이를 마우스에 투여했을 때 체중, 지방축적, 혈청과 간에서의 중성지방 함량이 억제되었고 혈중 렙틴 수준도 현저히 감소하였다(56, 57). 이는 녹차에 다량 함유된 카테킨과 카페인이 교감신경에 작용해 노르에피네프린의 분비의 촉진을 통해 베타 교감신경 수용체를 활성화시켜 열 발생을 통한 에너지소비를 유도하기 때문인 것으로 이해된다(58, 59).
매운맛은 없으나 캡사이신과 유사한 작용을 한다. 쥐에게 0.03%의 수준으로 12일 동안 섭취시켰을 때 지방조직의 감소가 관찰되었으며 Evodia 열매의 추출물을 0.02%의 수준으로 21일 동안 섭취시켰을 때 지방조직, 혈액과 간의 지방이 감소하였으며 체중의 감소도 관찰되었다. Evodiamine은 열의 생산과 방출을 동시에 유도함으로써 복부지방 조직과 체중의 감소를 유도하게 된다(87).

후속연구

이들은 작용기전이 각각 다르므로 각 개인의 특성에 따라 혼합하여 사용함과 동시 에 행동요법 (behavioral therapy)을 병 행함으로써더 효과적인 체중감량을 기대할 수 있을 것이다. 그러나 이들 기능성식품들은 그 효능이 임상실험에 대하여 일관적이지 못하거나 부작용의 우려가 있는 것도 있으므로 보다 정밀한 안전성 실험과 사람을 대상으로 한 체계적인 심층 연구가 요구된다. 어떤 종류의 항비만 기능성식품이 소개되든지 단순한 비만치료만을 위한 목적보다는 에너지 전체적인 조화를 이루며 개인의 건강상태가 고려되어야 한다는 것을 기억해야 할 것이다.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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