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차가버섯, 상황버섯 및 영지버섯 복합추출물 복용이 인체의 혈중 조혈모세포와 면역세포에 미치는 영향

The Effects of Extracts Mixture Drink from Inonotus Obliquus, Phellinus Linteus and Ganoderma Lucidum on Hematopoietic Stem Cells and Lymphocyte Subset of Blood in Human


본 연구는 차가버섯, 상황버섯, 영지버섯 혼합추출물(IPGE)음료 복용이 인체의 혈중 조혈모세포와 임파구 아형(Lymphocyte, $CD4^+T$ cell, $CD8^+T$ cell, Natural Killer cell) 증식에 미치는 영향을 관찰하기 위하여 수행하였다. 피험자는 건강한 지원자들로서 $40{\sim}70$대의 남여 일반인들로 하였다. 전체 39명을 모집하여 무작위 배정을 통해 27명, 12명 씩 2그룹으로 나누고 각각 버섯 복합추출물과 위약 음료를 따로 지급하여 4주 동안 매일 복용하게 하였다. 혈액은 복용 첫날부터 시작하여 2주 간격으로 피험자들로부터 채취되었으며 면역세포 수 측정에 사용되었다. 조혈모세포(hematopoietic stem cell)는 IPGE 음료 복용군에서 복용 전에 비하여 현저하게 증가하였으며 통계적으로 유의한 차이를 나타냈다(p<0.001). 임파구(lymphocyte)는 IPGE음료 복용 전과 후 간에 유의한 차이가 관찰되지 않았다. $CD4^+T$ 세포, $CD4^+T$ 세포 및 $CD4^+/CD8^+$ 비율은 시험 음료 복용 전과 후 간에 유의한 차이가 나타나지 않았다. 그리고 NK 세포도 IPGE 음료 복용 전과 후 간에 유의한 차이가 관찰되지 않았다. 본 연구결과를 종합해 볼 때 차가버섯, 상황버섯 및 영지버섯 혼합추출물(IPGE)음료는 조혈모세포의 증식효과를 현저하게 높게 나타내었기 때문에 총체적인 혈액세포 정상화를 통해 인체 건강증진에 긍정적인 효과를 나타낼 것으로 사료되었다.


This study was performed to investigate the effect of extract mixture(IPGE) drink from Inonotus Obliquus, Phellinus Linteus and Ganoderma Lucidum on hematopoietic stem cells and lymphocyte subset[lymphocyte, $CD4^+T$ cell, $CD8^+T$ cell, Natural Killer(NK) cells] of blood in 37 participants who were healthy and about $40{\sim}70$ years old. They were divided into two groups; extract mixture drink administration group(n=27) and placebo administration group(n=12). They were given the test drink daily for 4 weeks. Blood was obtained from the subjects every two week in the beginning of administration day to evaluate the $CD34^+$ hematopoietic stem cells and immune cells. As results, $CD34^+$ hematopoietic stem cells were significantly increased after taking IPGE drink for 4 weeks compared to that before taking the drink (p<0.001). There was no significant changes in number of lymphocytes, $CD4^+T$ cells, $CD8^+T$ cells, NK cells and in the ratio of $CD4^+/CD8^+$ cell after taking the test drink. From these results, it was suggested that IPGE have a good health effect by promoting the proliferation of the hematopoietic stem cells.

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이 논문을 인용한 문헌 (4)

  1. Youn, Myung-Ja ; O, Kwang-Joong ; Park, Kie-In 2011. "Anti-oxidant Effects of the Water Extracts from the Inonotus Obliquus against Cisplatin- Induced Damage in HEI-OC1 Cells" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 25(3): 451~458 
  2. Cho, Ju-Hyun ; Park, In-Jae ; Choi, Soo-Young ; Baik, Soon-Ok ; Kim, Choong-Sik 2014. "The Hepatoprotective Effect of Acanthopanax senticosus Fermentation Products in Fatty Liver Model" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(1): 40~46 
  3. Cho, Ju-Hyun ; Choi, Goo-Hee ; Park, In-Jae ; Baik, Soon-Ok ; Kim, Hyung-Ha ; Kim, Choong-Sik 2014. "Development of Functional Food Materials from Acanthopanax senticosus-Fermented Mushroom Mycelia" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(3): 411~418 
  4. Cho, Ju-Hyun ; Park, In-Jae ; Baik, Soon-Ok ; Choi, Soo-Young ; Choi, Goo-Hee 2014. "Single- and Repeated-dose Toxicities of Acanthopanax senticosus Fermentation Products in Rats" 한국식품과학회지 = Korean journal of food science and technology, 46(2): 249~255 


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