$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

차가버섯, 상황버섯 및 영지버섯 복합추출물 복용이 인체의 혈중 조혈모세포와 면역세포에 미치는 영향

The Effects of Extracts Mixture Drink from Inonotus Obliquus, Phellinus Linteus and Ganoderma Lucidum on Hematopoietic Stem Cells and Lymphocyte Subset of Blood in Human

초록

본 연구는 차가버섯, 상황버섯, 영지버섯 혼합추출물(IPGE)음료 복용이 인체의 혈중 조혈모세포와 임파구 아형(Lymphocyte, $CD4^+T$ cell, $CD8^+T$ cell, Natural Killer cell) 증식에 미치는 영향을 관찰하기 위하여 수행하였다. 피험자는 건강한 지원자들로서 $40{\sim}70$대의 남여 일반인들로 하였다. 전체 39명을 모집하여 무작위 배정을 통해 27명, 12명 씩 2그룹으로 나누고 각각 버섯 복합추출물과 위약 음료를 따로 지급하여 4주 동안 매일 복용하게 하였다. 혈액은 복용 첫날부터 시작하여 2주 간격으로 피험자들로부터 채취되었으며 면역세포 수 측정에 사용되었다. 조혈모세포(hematopoietic stem cell)는 IPGE 음료 복용군에서 복용 전에 비하여 현저하게 증가하였으며 통계적으로 유의한 차이를 나타냈다(p<0.001). 임파구(lymphocyte)는 IPGE음료 복용 전과 후 간에 유의한 차이가 관찰되지 않았다. $CD4^+T$ 세포, $CD4^+T$ 세포 및 $CD4^+/CD8^+$ 비율은 시험 음료 복용 전과 후 간에 유의한 차이가 나타나지 않았다. 그리고 NK 세포도 IPGE 음료 복용 전과 후 간에 유의한 차이가 관찰되지 않았다. 본 연구결과를 종합해 볼 때 차가버섯, 상황버섯 및 영지버섯 혼합추출물(IPGE)음료는 조혈모세포의 증식효과를 현저하게 높게 나타내었기 때문에 총체적인 혈액세포 정상화를 통해 인체 건강증진에 긍정적인 효과를 나타낼 것으로 사료되었다.

Abstract

This study was performed to investigate the effect of extract mixture(IPGE) drink from Inonotus Obliquus, Phellinus Linteus and Ganoderma Lucidum on hematopoietic stem cells and lymphocyte subset[lymphocyte, $CD4^+T$ cell, $CD8^+T$ cell, Natural Killer(NK) cells] of blood in 37 participants who were healthy and about $40{\sim}70$ years old. They were divided into two groups; extract mixture drink administration group(n=27) and placebo administration group(n=12). They were given the test drink daily for 4 weeks. Blood was obtained from the subjects every two week in the beginning of administration day to evaluate the $CD34^+$ hematopoietic stem cells and immune cells. As results, $CD34^+$ hematopoietic stem cells were significantly increased after taking IPGE drink for 4 weeks compared to that before taking the drink (p<0.001). There was no significant changes in number of lymphocytes, $CD4^+T$ cells, $CD8^+T$ cells, NK cells and in the ratio of $CD4^+/CD8^+$ cell after taking the test drink. From these results, it was suggested that IPGE have a good health effect by promoting the proliferation of the hematopoietic stem cells.

참고문헌 (42)

  1. Franz, H., Suganuma, M., Okabe, S., Sueoka, N., Kozu, T. and Sakai Y.: Japanese green tea as a cancer preventive in Humans. Nutr. Rev. 54, 56~70 (1996) 
  2. Ikekawa, T., Nakanish, M., Uehara, N., Chihara, O. and Fukuoka, F.: Antumor action of some Basidiomycetes, especially Phellinus linteus. Gann 59, 155-157(1968) 
  3. Bea, W.C., Kim, Y.S. and Lee, J.W.: Bioactive Substances from Ganoderma luciderm Kor. J. Microbiol. Biotechnol. 33, 75-83 (2005) 
  4. Lee, J.W. and Bang, K.W.: Biological activity of Phellinus spp. Food Industry and Nutrition 6, 25-33(2001) 
  5. Shon, M.Y., Seo, K.L, Choi, S.Y., Sung, N.J., Lee, S.w. and Park, S.K.: Chemical Compounds and Biological Activity of Phellinus baumii. J. Korean Soc Food Sci Nur 35 524~529(2006) 
  6. Chung, K.S., Kim, S.B. and Chung S.H.: Immunoactivities of the Protein-polysaccharides of the Tips of the Growing Carpophores of Ganoderma lucidum. Yakhak Hoeji, 41, 105~110(1997) 
  7. Oh, Y.S., Oh, M.S., Son, C.K., Cho, C.K. and Song, T.W.: The Effects of PSM on Immune Response. J. Kor. Oriental Med. 22, 46~52(2001) 
  8. Cha, E.l, Hwang, Y.J. and Kim, S.H.: Studies on physiological functionality proposal of Coriolus versicolor(Fr.) Quel and Ganoderma Lucidum (Fr.)Karst. Kor. J. Human Ecology 7, 31~46(2004) 
  9. Lee, S.M., Lee, S.B., and Lee M.C.: The Effect ofPhellinus Igniarius Extract Administration on Exercise-Performing Ability, the Level of Muscle Fatigue and Antioxidant System. The Kor. J. Exer. Nutr. 10, 173-179(2006) 
  10. Yearnl, K., Shuichi, K. and Tsutomu, T.: Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats(SHR). J. Nutr. Sci. Vitaminal. 34, 433~438(1988) 
  11. Kim, Y.D., Kim, N.S., Eom, S.Y., Kim, S.H., Kang, J.W., Lee, S.W., Park, S.Y., Kim, lS., Kim, H., Hong, J.S.: Effects of Extracts from the Mushroom Keumsa Sangwhang (Phellunus linteus) on Fasting Blood Glucose and Cholesterol Levels in Human. Kor. J. Food Culture, 23, 68-72(2008) 
  12. Shin, K.A., Kwon, D.K., and Song, Y.J.: The Effect of Ph ellinus Linteus Extract Supplementation on Exercise Performance, Mustle Fatigue and Related Blood Components. The Kor. J. Exer. Nutr. 11, 117~122(2007) 
  13. Shimizu, A., Yano, T., Saito, Y., and Inada, Y.: Isolation of an inhibitor of platelet aggregation from a fungus, Ganoderma lucidum. Chem. Pharm. Bull. 33, 3012-3015(1985) 
  14. Hong, W.K., Shin, J.H., Lee, Y.H., Park, D.K. and Choi, GS.: The clinical Effect of Phellinus Linteus Grown on Germinated Brown Rice in the Treatment of Atopic Dermatitis. Kor. J. Herbology, 23, 103-108(2008) 
  15. Hwang, B.H. and Lee, J.K.: Antitumor Substances from Mushrooms J. Kor. For. En. 24, 1-12(2005) 
  16. Hengst, J.C.D. and Mitchel, M.S.: Principles of combining biological response modifier with cancer chemotherapy. In Fundamentalis of cancer chemotherapy. Hellman, K. and Carter, S.K. (Eds.) Mcgraw-Hill Book Co., New York 64 (1987) 
  17. Kim, H.M., Han, S.B., Oh, GT., Kim, Y.H., Hong, D.H., Hon, N.D. and Yoo, LD.: Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int. J. Immunopharm. 18, 295~303(1996) 
  18. Chung, K.S., Kim, S.S., Kim, H.S., Han, M.W. and Kim, B.K.: Antitumor activity of Kp, Protein-Polysaccharide from the Mycelial Culture of Phellinus linteus. Yakhak Hoeji, 38, 158-165 (1994) 
  19. Tsukagoshi, S., Ohashi, F.: Protein-bound polysaccharide preparation, PS-K, effective against mouse sarcoma 180 and rat ascites hepatoma by oral use. Gann 65, 557~560 (1974) 
  20. Moon, C.K., Lee, H.S., Mock, M.S. and Kim D.O.: Antitumor Activity of the Polysaccharide Fraction (Copolang) from Coriolus versicolor and its Effects on the Immune Function. Yakhak Hoeji 31, 126~ (1987) 
  21. Chihara, G., Hamura, J, Maeda, Y.Y., Arai, Y. and Fukuoka, F.: Fractionation and Purification of the polysaccharides with marked antitumor activity, especially lentinan from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res. 30, 2776~2781(1970) 
  22. 심재성, 이병화, 강석중: 차가버섯의 실체와 응용. 국제농업개발원, pp.35-173 (2003) 
  23. Eom, S.Y., Zhang, Y.w., Kim, N.S., Kang, lW., Hahn, Y.S., Song, H.G, Park, S.Y., Kim, lS., Kim, H. and Kim, Y.D.: Effects of Keumsa Sangwhang (Phellinus Linteus) Mushroom Extracts on the Natural Killer Cell Activity in Human. Korean J. Food Sci. 38, 717-719 (2006) 
  24. Kim, GY., Oh, w.K., Shin, B.C., Shin, Y.L, Park, Y.C., Ahn, S.C., Lee, J.D., Bae, Y.S., Kwak, J.Y., Park, Y.M.: Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+ DC and type I helper T cell-dominant immune state. FEBS Letters 576, 391~400(2004) 
  25. Seo, J.H.:The Effects of Phellinus Linteus Administration on Lymphocyte Subset and Cytokines of Blood by Athletic Player. The Kor. J. Exercise Nutr.11, 109-116(2007) 
  26. Oh, G.T., Han, S.B., Kim, H.M., Han, M.W. and Yoo, I.D. Immunostimulating activity of Phellinus linteus extracts to B-Iymphocyte. Arch. Pharm. Res. 15, 379~381(1992) 
  27. Kim, GY., Choi, GS., Lee, S.H. and Park, Y.M.: Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-a from peritoneal macrophages. J. Ethnopharmacology 95, 69~76(2004) 
  28. Shin, H.W., Kim, H.W., Choi, E.C., Tho S.H. and Kim B.K.: Studies on Inorganic Composition and Immunopotentiating Activity of Ganoderma lucidum in Korea. Kor. J. Pharmacogn. 16, 181-190(1985) 
  29. Shiao, M.S., Lee, K.R., Lin, J.J. and Wang, C.T.: Phytochemicals for Cancer Prevention II. P. 342 In Ho, C.T.(eds), Teas, Spices and Herbs. Amreican Society, Washington. (1994) 
  30. Oh IY and Chung, K.S.: Flowcytometric Analysis of the Antitumor and Immunomodulatory Activities ofGLB-A and GLB-B, the Protein-Polysaccharide Fractions of the Growing Tips of Ganoderma Luciderm. Yakhak Hoeji, 42, 487-493(1998) 
  31. Moon, C., Hyun, J.W, Kim, H.W, Shim, M.J.. and Kim, B.K.: Immunostimulating Activity by Protoplast Fusants between Ganoderma lucidum and Lentinus edodes J. Appl. Pharmacol. 8, 199-205(2000) 
  32. Bae, IH.: Effects of Ganoderma luciderm on the IL-l, TNF and IL-2 Gene Expression of Macrophages. J. Korean Soc Food Sci Nutr. 26, 978-982(1997) 
  33. O, J.Y., Cho, KJ., Chung, S.H., Kim, J.H., Lillehoj, H.S. and Chung K.S.: Activation of Macrophages by GLB, a Proteinpolysaccharide ofthe Growing Tips of Ganoderma Lucidum. Yakhak Hoeji, 42, 302-306(1998) 
  34. Kim, S.W and Kim, E.S.: Studies on the Immunomodulating Effects of Polysaccharide Extracted from Ganoderma lucidum on Macrophage. J. Korean Soc. Food Sci. Nutr. 26, 148-153(1997) 
  35. Baek, S.J., Kim, YS., Yong, H.M., Chae, J.B., Lee, S.A., Bae, WC., Park, D.W, Kim, D.H., Lee, J.W, Park, S.K.: Antimetastatic Effect of Proteoglycan Isolated from the Mycelium of Ganoderma lucidum IY009 in vitro and in vivo. Yakhak Hoeji, 46, 11-17(2002) 
  36. Sutherland, D.R, Anderson, L., Keeney, M., Nayer, R. and Chin-Yee, I.: The ISHAGE guidelines for CD34+ cell determination by flow cytometry. J Hematother 5, 221-226 (1996) 
  37. Kim, M.J. M.D., Kim, H.S. M.D., Park, Q. M.D., Kim, H,O. MD., and Song K.S. M.D.: Multicenter Study on Flow Cytometric Enumeration of CD34+ Hematopoietic Stem Cells. Kor. J. Clin. Pathol. 18,265-270(1998) 
  38. Bjorksten, B., Quie, P.G.: Abnormalities of circulating phagocyte function; recent advance in clinical immunology. Edited (Thompson RA) Churchill Livingston and New York, pp. 181-202 (1977) 
  39. So, J.M., Seo, J.H.: The Effects of Phellinus Linteus Extract Supplement on Immune Cell by Athletes. Kor. J. Physical Education, 45, 501~511 (2006) 
  40. Golub, E.S., Green, D.R.: Immunology. Sunderland, NY: Sinaur Associate. (1991) 
  41. Orange, J.S., Ballas, Z.K.: Natural killer cells in human health and disease. Clinical Immunology, 118, 1~10(2006) 
  42. Kim, H., Kim, Y.D., Eom, S.Y, Zhang, Y.W, Kim, N.S., Hahn, Y.S., Shin, K.S., Song, H.G., Park, S.Y, Kim, J.S. and Kang, J.W.: Effects of Keumsa Sangwhang (Phellinus linteus) Mushroom Extracts on the IL-12, IFN-y and TNF-a expression in Human. Kor. J. Promot. Dis. Prev., 6, 245-249(2006) 

이 논문을 인용한 문헌 (4)

  1. Youn, Myung-Ja ; O, Kwang-Joong ; Park, Kie-In 2011. "Anti-oxidant Effects of the Water Extracts from the Inonotus Obliquus against Cisplatin- Induced Damage in HEI-OC1 Cells" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 25(3): 451~458 
  2. Cho, Ju-Hyun ; Park, In-Jae ; Choi, Soo-Young ; Baik, Soon-Ok ; Kim, Choong-Sik 2014. "The Hepatoprotective Effect of Acanthopanax senticosus Fermentation Products in Fatty Liver Model" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(1): 40~46 
  3. Cho, Ju-Hyun ; Choi, Goo-Hee ; Park, In-Jae ; Baik, Soon-Ok ; Kim, Hyung-Ha ; Kim, Choong-Sik 2014. "Development of Functional Food Materials from Acanthopanax senticosus-Fermented Mushroom Mycelia" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(3): 411~418 
  4. Cho, Ju-Hyun ; Park, In-Jae ; Baik, Soon-Ok ; Choi, Soo-Young ; Choi, Goo-Hee 2014. "Single- and Repeated-dose Toxicities of Acanthopanax senticosus Fermentation Products in Rats" 한국식품과학회지 = Korean journal of food science and technology, 46(2): 249~255 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일