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NTIS 바로가기동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, v.23 no.6, 2009년, pp.1423 - 1430
정재하 (동국대학교 한의과대학 방제학교실) , 윤현정 (심혈관계질환 천연물 연구개발센터) , 허준영 (동국대학교 한의과대학 방제학교실) , 김재은 (심혈관계질환 천연물 연구개발센터) , 박선동 (심혈관계질환 천연물 연구개발센터)
Rosmarinic acid frequently found as a secondary metabolite in herbs and medicinal plants, has exhibited antimicrobial, antiviral, antioxidative, and anti-inflammatory activities. The proliferation and migration of human aortic smooth muscle cells (HASMC) in response to activation by various stimuli ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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최근 보고된 Rosmarinic acid 활성 작용은? | Rosmarinic acid는 항산화, 항염증, 항바이러스, 항균, 항암 작용 등 많은 생물학적 활성이 보고되고 있다. 또한 최근에는 사람 상피세포에서 NF-κB 활성을 저해함으로써 TNF-α에 의해 유도되는 CCL1과 CCR3를 억제한다는 보고도 있다 18). Rosmarinic acid가 동맥경화 질환의 예방 및 치료에도 활성을 가지는 지 알아보기 위하여 사람동맥평활근세포인 HASMC에 처리하여 분자, 세포생물학적 실험을 수행하였다. | |
Rosemarinic acid는 어디에 함유되어 있는가? | Rosemarinic acid는 꿀풀과 (Lamiaceae herbe) 계통의 Salvia officinalis (sage), 로즈마리 (Rosmarinus officinalis), 하고초 (Prunella vulgaris), 소엽 (Perilla frutescens), 바질 (Ocimum basilicum), 곽향 (Teucrium veronicoides), 형개 (Schizonepeta tenuifolia var. japonica), 향유 (Elsholtzia ciliata), 박하 (Mentha arvensis var. piperascens) 등에 함유되어 있다. Rosemarinic acid는 360. | |
Rosemarinic acid의 분자량은? | piperascens) 등에 함유되어 있다. Rosemarinic acid는 360.32 Da의 분자량을 갖는 polyphenolic compound로서 (α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-oxy]-3,4-dihydroxy-[R-(E)]-benzene-propanoic acid의 구조를 가지고 있다 4). |
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