최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.25 no.3, 2010년, pp.19 - 25
Objective : The aim of this study was to investigate anti-inflammatory activity of SD-01 methanol extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods : Cytotoxic activity of SD-01 methanol extract on RAW 264.7 cells was measured using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-z...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
염증반응의 만성화에 의해 유발되는 질환은? | 반복적인 조직의 손상이나 재생에 의해 염증반응이 지속되면 염증관련 세포에서 활성 산소종 (reactive oxygen species, ROS)과 활성 질소종 (reactive nitrogen species, RNS)이 과다 생성됨으로써 염증성 관련 질환이 유발된다1). 류마티스 관절염, 동맥경화증, 위염, 천식 등이 염증반응의 만성화에 의해 유발되는 질환이다2). | |
천연약물에서 신약을 찾기 시작한 배경이 된 화학합성물을 이용한 신약개발의 어려움은? | 신약개발은 전형적인 지식기반 연구개발로 고부가가치를 창출하는 21세기형 산업이다. 그러나 화학합성물로부터 신약개발은 신물질에서 허가까지 평균 14.9년이 걸리며, 성공률 또한 낮으며, 개발비용은 날로 높아지고 있다. 따라서 최근에 이러한 어려움의 돌파구로 신약연구부문에서는 천연약물 (한약)에서 신약을 찾기 시작했고, 이에 대한 특허 건수도 꾸준히 증가하고 있다15). | |
ROS의 역할은? | ROS는 다양한 세포 스트레스 메커니즘에 관여하고 있고 염증반응에 관련된 메카니즘인 nuclear factor-kappa B (NF-κB)의 활성을 조절한다는 보고도 있다3). 실제로 뛰어난 항산화 물질이 NF-κB의 활성을 억제하고4), 세포 내의 ROS 생성을 감소시킨다는5) 보고가 있다. |
Azad N, Rojanasakul Y, Vallyathan V. Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev. 2008 ; 11(1) : 11-5.
Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 2003 ; 24(1) : 25-9.
Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through downregulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002 ; 23(6) : 983-91.
Bai SK, Lee SJ, Na HJ, Ha KS, Han JA, Lee H, Kwon YG, Chung CK, Kim YM. beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Exp Mol Med. 2005 ; 37(4) : 323-34.
Kamata H, Manabe T, Kakuta J, Oka S, Hirata H. Multiple redox regulation of the cellular signaling system linked to AP-1 and NFkappaB: effects of N-acetylcysteine and H2O2 on the receptor tyrosine kinases, the MAP kinase cascade, and IkappaB kinases. Ann N Y Acad Sci. 2002 ; 973 : 419-22.
Desai A, Vyas T, Amiji M. Cytotoxicity and apopotosis enhancement in brain tumor cells upon coadministration of paclitaxel and ceramide in nanoemulsion formulations. J Pharm Sci. 2008 ; 97(7) : 2745-56.
Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med. 1999 ; 27 : 612-6.
Rong Y, Geng Z, Lau BH. Ginko biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic Biol Med. 1996 ; 20 : 121-7.
Wang S, Chen Y, He D, He L, Yang Y, Chen J, Wang X. Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation. J Ethnopharmacol. 2007 ; 114(3) : 458-62.
Moynagh PN. The NF-kappaB pathway. J Cell Sci. 2005 ; 118(Pt 20) : 4589-92.
Hyun-kyoo Shin, The research on the strategy for the globlization of the oriental medicine, 보건복지부, 2001, p.3
Shin HK , Sung HJ. Research tendency of the middle & long period future estimating Oriental medicine, Korean J Oriental medicine. 1996 ; 2 : 491-3.
Huang CH, Horng LY, Chen CF, Wu RT. Chinese herb Radix Polygoni Multiflori as a therapeutic drug for liver cirrhosis in mice. J Ethnopharmacol. 2007 ; 114(2) : 199-206.
Zhang YZ, Shen JF, Xu JY, Xiao JH, Wang JL. Inhibitory effects of 2,3,5,4'-tetrahydroxystilbene-2 -O-beta-D-glucoside on experimental inflammation and cyclooxygenase 2 activity. J Asian Nat Prod Res. 2007 ; 9(3-5) : 355-63.
Li RW, David Lin G, Myers SP, Leach DN. Anti-inflammatory activity of Chinese medicinal vine plants. J Ethnopharmacol. 2003 ; 85(1) : 61-7.
Chan YC, Wang MF, Chen YC, Yang DY, Lee MS, Cheng FC. Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils. Am J Chin Med. 2003 ; 31(1) : 71-7.
Chan CM, Chan YW, Lau CH, Lau TW, Lau KM, Lam FC, Che CT, Leung PC, Fung KP, Lau CB, Ho YY. Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis. J Ethnopharmacol. 2007 ; 109(1) : 10-20.
Chan YC, Wang MF, Chang HC. Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice. Am J Chin Med. 2003;31(2):171-9.
Wang SX, Hu LM, Gao XM, Guo H, Fan GW. Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect. Neurochem Res. 2010 ; 35(7) : 1029-37.
Salvianolic acid B attenuates hepatocyte apoptosis by regulating mediators in death receptor and mitochondrial pathways. Exp Biol Med. 2010 ; 235(5) : 623-32.
Su CC, Chen GW, Lin JG. Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells. Int J Mol Med. 2008 ; 22(5) : 613-8.
Liu JJ, Liu WD, Yang HZ, Zhang Y, Fang ZG, Liu PQ, Lin DJ, Xiao RZ, Hu Y, Wang CZ, Li XD, He Y, Huang RW. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Ann Hematol. 2010 May 30. [Epub ahead of print]
Tian HL, Yu T, Xu NN, Feng C, Zhou LY, Luo HW, Chang DC, Le XF, Luo KQ. A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer Lett. 2010 May 20. [Epub ahead of print]
Kim AJ, Kim YO, Shim JS, Hwang JK. Immunostimulating activity of crude polysaccharide extract isolated from Curcuma xanthorrhiza Roxb. Biosci Biotechnol Biochem. 2007 ; 71(6) : 1428-38.
Kang YJ, Park KK, Chung WY, Hwang JK, Lee SK. Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. J Pharmacol Sci. 2009 ; 111(3) : 276-84.
Handayani T, Sakinah S, Nallappan M, Pihie AH. Regulation of p53-, Bcl-2- and caspasedependent signaling pathway in xanthorrhizolinduced apoptosis of HepG2 hepatoma cells. Anticancer Res. 2007 ; 27(2) : 965-71.
Oh HI, Shim JS, Gwon SH, Kwon HJ, Hwang JK. The effect of xanthorrhizol on the expression of matrix metalloproteinase-1 and type-I procollagen in ultraviolet-irradiated human skin fibroblasts. Phytother Res. 2009 ; 23(9) : 1299-302.
Lee LY, Shim JS, Rukayadi Y, Hwang JK. Antibacterial activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against foodborne pathogens. J Food Prot. 2008 ; 71(9) : 1926-30.
Choi BM, Lee JA, Gao SS, Eun SY, Kim YS, Ryu SY, Choi YH, Park R, Kwon DY, Kim BR. Brazilin and the extract from Caesalpinia sappan L. protect oxidative injury through the expression of heme oxygenase-1. Biofactors. 2007 ; 30(3) : 149-57.
Washiyama M, Sasaki Y, Hosokawa T, Nagumo S. Anti-inflammatory constituents of Sappan Lignum. Biol Pharm Bull. 2009 ; 32(5) : 941-4.
Bae IK, Min HY, Han AR, Seo EK, Lee SK. Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. Eur J Pharmacol. 2005 ; 513(3) : 237-42.
Zhong X, Wu B, Pan YJ, Zheng S. Brazilein inhibits survivin protein and mRNA expression and induces apoptosis in hepatocellular carcinoma HepG2 cells. Neoplasma. 2009 ; 56(5) : 387-92.
Kim KJ, Yu HH, Jeong SI, Cha JD, Kim SM, You YO.I nhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus. J Ethnopharmacol. 2004 ; 91(1):81-7.
Gomez PF, Pillinger MH, Attur M, Marjanovic N, Dave M, Park J, Bingham CO 3rd, Al-Mussawir H, Abramson SB. Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts. J Immunol. 2005 ; 175(10) : 6924-30.
Abul KA, Andrew HL, Shiv P. 세포분자면역학, 6판. 서울 : 이퍼블릭. 2008 : 271-96.
Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002 ; 2(10) : 725-34.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.