[논문]C57BLKS/J-<tex>$db/db$</tex> 마우스에서 흑삼의 항당뇨 효과

강신정; 김애정

doi:10.9799/ksfan.2011.24.4.770

C57BLKS/J-$db/db$ 마우스에서 흑삼의 항당뇨 효과
Anti-Diabetic Effect of Black Ginseng in C57BLKS/J-$db/db$ Mice 원문보기

한국식품영양학회지 = The Korean journal of food and nutrition, v.24 no.4, 2011년, pp.770 - 776

강신정 (중부대학교 한약자원학과) , 김애정 (경기대학교 대체의학대학원 대체의학과)

초록
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본 연구는 흑삼의 항당뇨 효과를 알아보고자 4그룹(정상군, 당뇨 쥐, 당뇨 쥐에게 백삼을 투여한 군, 당뇨 쥐에게 흑삼을 투여한 군)으로 나누어 6주간 실시하였다. 6주 후 식품섭취량, 체중 증가량을 비교하였는데, 식품섭취량, 체중 증가량에는 그룹 간에 유의적인 차이가 나타나지 않았으나, OGTT(oral glucose tolerance test)와 IPITT(intraperitoneal insulin tolerance test) 경우는 흑삼 투여군에서 긍정적인 결과를 나타내었다. 또한 혈청 포도당과 인슐린농도에 미친 영향을 비교, 분석한 결과, 흑삼 투여군에서 공복 시 혈당, 혈청 포도당, 인슐린 농도가 유의적으로 감소하였다. 이 결과를 미루어 볼 때 흑삼이 백삼에 비해 당뇨를 치료하는데 더 효과적일 것으로 판단된다.

주제어

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문제 정의

In short, the principal objective of this study was to determine which type of ginseng (white or black) has more effective on the anti-diabetic effect in C57BL/KSJ-db/db mice, a type 2 diabetic mice model.
This study was designed for the comparison of anti-diabetic effect between white (WG) and black ginseng (BG) in C57BLKS/ J-db/db mice. Six-weeks-old mice male db/db mice were administrated with once daily 300 ㎎/㎏ of each of WG and BG for 6 weeks, db/m mice as normal group and db/db mice as diabetic positive group were fed without treatment of WG and BG.

가설 설정

6) Means in the same row not sharing a common superscript are significantly different(p<0.05) between groups.

제안 방법

In this study, we measured an oral glucose tolerance test (OGTT) and an IPITT to determine the effects of WG and BG administration at five weeks of the experiment (Table 4 and 5). We observed that BG treatment progressively reduced blood glucose level compared to the positive diabetic group at 90 min after the glucose load even thought two type of treatment groups failed to return to the baseline after 120 min.
For finding out anti-diabetic effect, food consumption, body weight gain, oral glucose tolerance test (OGTT), intraperitoneal insulin tolerance test (IPITT) and blood level of glucose and insulin were examined. The results were summarized by comparing the results getting from db/db mice administrating WG and BG with those of diabetic positive group for 6 weeks. BG treatment group showed more significant differences on fasting blood glucose, suppression level against increasing blood insulin compared with that of WG group.
The two types of materials (WG and BG) were intraperitoneally administered at a concentration of 300 ㎎/㎏ body weight using sonde once per day for 6 weeks. All procedures involving animals were approved by Experimental Animal Care Committee of Chungbuk University, Chungbuk, Korea.

데이터처리

Results were expressed as mean±SD of 8 mice per group and statistical significance was assessed via one-way analysis of variance (ANOVA) and Duncan's multiple range test using SAS software (SAS analysis system, ver. 8.1).

성능/효과

But the BG group showed a rapid removal of blood glucose compared to the WG group. Our results clearly indicate that the BG treatment exhibited the most efficient removal of blood glucose over the entire period during the OGTT and IPITT.

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