[논문]Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis

Fallahzadeh, Hossein; Jalali, Ali; Momayyezi, Mahdieh; Bazm, Soheila

doi:10.5230/jgc.2015.15.4.256

Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis 원문보기

Journal of gastric cancer : jgc, v.15 no.4, 2015년, pp.256 - 261

Fallahzadeh, Hossein (Research Center of Prevention and Epidemiology of Non-Communicable Disease, Shahid Sadoughi University of Medical Sciences) , Jalali, Ali (Department of Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences) , Momayyezi, Mahdieh (Research Center of Prevention and Epidemiology of Non-Communicable Disease, Shahid Sadoughi University of Medical Sciences) , Bazm, Soheila (Department of Health Education, Faculty of Health, Shahid Sadoughi University of Medical Sciences)

Abstract ▼ AI-Helper

Purpose: Gastric cancer is the third leading cause of cancer-related mortality, with the incidence and mortality being higher in men than in women. Various studies have shown that eating carrots may play a major role in the prevention of gastric cancer. We conducted a meta-analysis to determine the relationship between carrot consumption and gastric cancer. Materials and Methods: We searched multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx. The following search terms were used: stomach or gastric, neoplasm or cancer, carcinoma or tumor, and carrot. Statistical analyses were performed using Comprehensive Meta Analysis/2.0 software. Results: We retrieved 81 articles by searching the databases. After considering the inclusion and exclusion criteria, 5 articles were included in this study. The odds ratio (OR) obtained by fixed effects model showed that a 26% reduction in the risk of gastric cancer has been associated with the consumption of carrots) OR=0.74; 95% confidence interval=0.68~0.81; P<0.0001). According to funnel graph, the results showed that the possibility of a publication bias does not exist in this study. Conclusions: The findings of this study showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.

주제어

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문제 정의

Several studies have been conducted to examine the relationship between eating carrots and prevention of gastric cancer worldwide, but they have not been approved. Therefore, this meta-analysis aimed to investigate the relationship between carrot consumption and prevention of gastric cancer.

제안 방법

All articles were adjusted based on age, sex, and smoking criteria. Three articles were adjusted for body mass index,^18,19,21 three articles for alcohol consumption,^15,18,20 two articles for salt intake,^18,21 two for eating fruits and raw vegetables^19,20 and two for consuming vitamins.
Thereafter, all selected studies were analyzed by using the software. In addition, the studies were sub-grouped based on the type of study, sex of the subjects, anatomical view of the gastric (cardia, non-cardia), and a family history of gastric cancer.

이론/모형

We used two models to calculate the OR with 95% CI: random effects (DerSimonian and Laird)¹⁷ method and fixed effects model. We used linear regression Egger’s and Begg’s rank correlation and funnel plot to assess publication bias (P＜0.

성능/효과

Results obtained from observational studies (case-control, cohort) showed that consumption of carrots is associated with a decrease in the risk of gastric cancer. In addition, the results of this study showed that carrot intake could reduce the risk of gastric cancer by up to 26% (OR=0.74; CI=0.68~0.81; P＜0.0001). The present study suggests an inverse relationship between eating carrots and the risk of gastric cancer.
In conclusion, the findings of this study showed an inverse relationship between the consumption of carrots and the risk of gastric cancer. This property of carrots has a greater effect in gastric cardia cancer than in other types of cancer.
The OR is calculated by fixed effects model, which showed that eating carrots decreased the risk of gastric cancer by 26% (OR=0.74; 95% CI=0.68~0.81; P＜0.0001, Fig. 2).

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