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NTIS 바로가기대한한방내과학회지 = The journal of internal Korean medicine, v.38 no.6, 2017년, pp.980 - 999
Objectives: This study aimed to evaluate the efficacy of Daegunjoong-tang for improvement of gastrointestinal motility after surgery due to gastrointestinal cancer by analyzing the existing clinical research. Methods: Clinical studies about Daegunjoong-tang for improvement of gastrointestinal motili...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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소화기암이란 무엇인가? | 소화기암이란 위암, 대장암, 직장암, 간암, 담도암, 췌장암 등을 포괄하는 것으로, 인체내에서 음식물을 소화하고 흡수시키기 위한 기본적인 장기에 발생하는 암이다1. 소화기암은 국내암발생률에서 높은 순위를 차지한다. | |
국내 암발생률에 따르면 소화기암들은 어떠한 순위를 가지는가? | 소화기암은 국내암발생률에서 높은 순위를 차지한다. 2014년 국가암등록통계에 따르면, 위암은 국내에서 갑상선암에 이어 두 번째로 많이 발생한 암이며, 대장암은 3위, 간암은 6위, 췌장암은 8위, 담낭 및 기타 담도암은 9위로, 대부분 유병률 10위권 이내에 분포하고 있다2. | |
대건중탕은 어떠한 약재들로 구성되었는가? | 이러한 수술후 위장관 운동성저하로 인한 마비성 장폐쇄에 한의임상에서는 대건중탕을 많이 사용해왔다. 대건중탕은 후한시대 장중경이 저작한≪금궤요략≫에 처음 수록된 처방으로, 촉초, 건강, 인삼, 교이로 구성되어 있다9. 건강과 인삼을 합하여 理中의 의미가 포함되어 있는 방제이다. |
HS Kim. Symptom Cluster and the Relationship of Performance Status, Anxiety, Depression, and Symptom Interference in Patients with Gastrointestinal Cancer: Gastric, Colorectal, Liver Cancer. Journal of The Korean Data Analysis Society 2013;15(5):2571-87.
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Katsuno H, Maeda K, Ohya M, Yoshioka K, Tsunoda A, Koda K, et al.Clinical pharmacology of daikenchuto assessed by transit analysis using radiopaque markers in patients with colon cancer undergoing open surgery: a multicenter double-blind randomized placebo-controlled study (JFMC39-0902 additional study). J Gastroenterol 2016;51(3):222-9.
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Lee KK. Synopsis of Prescriptions of the Golden Chamber. Beijing: People's Medical Publishing House; 1989, p. 253-6.
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Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A, Komatsu Y, et al. Effects of Dai-kenchu-to on intestinal obstruction following laparotomy. J Smooth Muscle Res 1999;35:47-54.
Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, et al. Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model. J Gastroenterol 2011;46(10):1187-96.
Kono T, Koseki T, Chiba S, Ebisawa Y, Chisato N, Iwamoto J, et al. Colonic vascular conductance increased by Daikenchuto via calcitonin generelated peptide and receptor-activity modifying protein 1. J Surg Res 2008;150(1):78-84.
Yamada T, Matsumoto S, Matsuda MKA, Shinji S, Yokoyama Y, Takahashi G. The effect of Daikenchuto on postoperative intestinal motility in patients with right-side colon cancer. Surg Today 2017;47(7):865-71.
Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, et al. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol Gastrointest Liver Physiol 2010; 298(6):G970-5.
Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Ver 5.1.0 [updated Mar 2011]. The Cochrane Collaboration 2011 Available from http://handbook.cochrane.org.
Hoshino N, Kawada K, Hida K, Wada T, Takahashi R, Yoshitomi M, et al. Effect of Daikenchuto (TJ-100) on gastrointestinal symptoms following laparoscopic colectomy in patients with colon cancer: study protocol for a randomized controlled trial. Trials 2017 Nov 21;18(1):553.
Katsuno H, Maeda K, Kaiho T, Kunieda K, Funahashi K, Sakamoto J, et al. Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902). Jpn J Clin Oncol 2015;45(7):650-6.
Yoshikawa K, Shimada M, Wakabayashi G, Ishida K, Kaiho T, Kitagawa Y, et al. Effect of Daikenchuto a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial. J Am Coll Surg 2015;221(2):571-8.
Endo S, Nishida T, Nishikawa K, Nakajima K, Hasegawa J, Kitagawa T, et al. Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. Am J Surg 2006;192(1):9-13.
Okada K, Kawai M, Hirono S, Fujii T, Kodera Y, Sho M, et al. Evaluation of the efficacy of daikenchuto (TJ-100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebocontrolled trial. Surgery 2016;159(5):1333-41.
Shimada M, Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, et al. Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001). Int J Clin Oncol 2015;20(1):95-104.
Sato Y, Katagiri F, Inoue S, Itoh H, Takeyama M. Dai-kenchu-to raises levels of calcitonin generelated peptide and substance P in human plasma. Biol Pharm Bull 2004;27(11):1875-7.
Kono T, Kaneko A, Omiya Y, Ohbuchi K, Ohno N, Yamamoto M. Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine. Am J Physiol Gastrointest Liver Physiol 2013; 304(4):G428-36.
Mochiki E, Yanai M, Ohno T, Kuwano H. The effect of traditional Japanese medicine (Kampo) on gastrointestinal function. Surg Today 2010; 40(12):1105-11.
Shibata C, Sasaki I, Naito H, Ueno T, Matsuno S. The herbal medicine Dai-Kenchu-Tou stimulates upper gut motility through cholinergic and 5-hydroxytryptamine 3 receptors in conscious dogs. Surgery 1999;126(5):918-24.
Lee NH, Cho JH, Son CG, Yoo HS, Lee YW, Yoon DH, et al. Analysis of Studies on Quality of Life according to Cancer Types and Symptoms. Korean J Orient Int Med 2006;27(3):555-60.
Lee EH, Park HB, Kim MW, Kang SH, Lee HJ, Lee WH, et al. Analyses of the Studies on Cancer-Related Quality of Life Published in Korea. Radiat Oncol J 2002;29(4):359-66.
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