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[국내논문] 신생아중환자의 약동학적 다양성에 영향을 미치는 요인
Contributing Factors on Pharmacokinetic Variability in Critically Ill Neonates 원문보기

한국임상약학회지 = Korean journal of clinical pharmacy, v.27 no.2, 2017년, pp.63 - 68  

안숙희 (원광대학교 약학대학)

Abstract AI-Helper 아이콘AI-Helper

Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. The aim of this study was to investigate the factors affecting the pharmacokinetic parameters of drugs, which are commonly used in critically ill neonates. Factors that refl...

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문제 정의

  • 본 종설에서는 신생아에게 주로 사용되는 약물의 약동학 파라미터에 영향을 주는 요인에 대하여 신생아의 성숙(maturation) 정도를 반영하는 특성인자, 장기의 기능, 공존질환과 치료요법, 병용 약물 등의 관점에서 고찰하여 신생아에게 적절한 약물의 용량과 모니터링 지침의 설정에 도움이 되고자 한다.
본문요약 정보가 도움이 되었나요?

질의응답

핵심어 질문 논문에서 추출한 답변
신생아는 어떤 시기인가? 신생아는 각종 장기와 효소의 기능이 미숙하고, 성장과 발달이 이루어지는 시기이다. 따라서 신생아는 성인과 다른 약동학적 특성을 지닌다.
신생아중환자실에서 주로 사용되는 약물은 무엇인가? 신생아중환자실에서 주로 사용되는 aminophylline (theophylline), phenobarbital, gentamicin, amikacin, vancomycin등의 약물은 환자 개인 간의 약물동태학적 특성이 다양하여 약물혈중농도모니 터링(therapeutic drug monitoring, TDM) 서비스를 통하여 용량을 조정하고 있다. 신생아 경련의 일차 치료 약물로 사용되는 phenobarbital의 약동학 연구 결과를 보면, 분포용적의 평균이 0.
신생아는 어떤 약동학적 특성을 갖는가?  따라서 신생아는 성인과 다른 약동학적 특성을 지닌다. 체내 총 수분량은 성인에 비해 증가하고 지방의 양은 감소하며 약물의 단백결합이 감소하여 약물의 분포가 변화한다. 1-2) 또한 간혈류와 간대사효소의 활성, 신장배설의 차이로 인하여 약물의 청소율(clearance)에 변화가 나타난다.2-4) 신생아에서 약물의 분포용적, 반감기, 청소율 등은 소아나 성인과 다른 범위를 나타내며, 개체간의 차이가 크게 나타난다.
질의응답 정보가 도움이 되었나요?

참고문헌 (77)

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