[논문]항암제와 한약재의 병용투여 시 암세포 증식억제 효과에 대한 국내 실험연구 문헌고찰

이지은; 최진용; 한창우; 최준용; 박성하; 김소연

doi:10.14374/hfs.2017.25.3.391

항암제와 한약재의 병용투여 시 암세포 증식억제 효과에 대한 국내 실험연구 문헌고찰
A Review on Experimental Research about Anticancer Drug Combined Treatment with Herbal Medicine for Killing or Inhibiting Proliferation of Cancer cells in Korea. 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.25 no.3, 2017년, pp.391 - 412

이지은 (부산대학교 한의학전문대학원 한의학과) , 최진용 (부산대학교 한의학전문대학원 한의학과) , 한창우 (부산대학교 한의학전문대학원 한의학과) , 최준용 (부산대학교 한의학전문대학원 한의학과) , 박성하 (부산대학교 한의학전문대학원 한의학과) , 김소연 (부산대학교 한의학전문대학원 한의학과)

Abstract ▼ AI-Helper

Objective : In this study, we searched the experimental research about combined treatment of anticancer drug and herbal medicine for killing or inhibiting proliferation of Cancer cells searched in OASIS and KISS. This study aimed to analyze the experimental research paper about anticancer drug combined treatment with herbal medicine. Methods : We collected the research paper including killing or inhibiting proliferation of Cancer cells in OASIS and KISS using keyword anticancer drug with herbal medicine, tumor suppressor with herbal medicine, inhibition of Cancer with herbal medicine and combined treatment with herbal medicine. Assorting by cancer cells, we analyzed experimental results cancer cell viability, anticancer drug dosage, tumor weight and survival rate. Also, we checked the effects of herbal medicine on cancer and additive effect reducing side effect of anticancer drug. Results : Total 45 studies were selected. 38 studies reported combined treatment of anticancer drug and herbal medicine was more effective than only anticancer drug. The death of cancer cells was synergistically induced by the cotreatment of anticancer drug and herb extracts. The studies suggest that the cotreatment of anticancer drug and herb extracts could reduce side effect of anticancer drug. In addition, some studies reported cotreatment mechanism like apoptotic death signal processes. In combined treatment of anticancer drug and herb extracts, The expression of Fas/Fas L, Bax, Bcl2, Caspase-3 etc.. was markedly increased in cancer cells. Conclusions : Our results suggest that anticancer drug combined treatment with herbal medicine could be efficient for killing or inhibiting proliferation of cancer cells. However, this paper had some limitation as follows: First, collected studies have been published only for korean journal. Second, results of research and effects of combined treatment are not collected objectively. To solve these problems, more objective and balanced studies should be performed.

주제어

질의응답

핵심어	질문	논문에서 추출한 답변
	항암화학 요법의 경우 일반적으로 치료 횟수가 증가할수록 부작용은 증가하는가, 감소하는가?	서양의학에서의 암 치료법은 외과처치, 방사선요법, 화학요법, 호르몬요법, 면역요법 등이 사용되고 있지만 그에 수반되는 부작용과 한계점으로 보다 효과적이고 부작용이 적은 치료방법이 요구된다. 특히 항암화학 요법의 경우 일반적으로 치료 횟수가 증가할수록 부작용이 증가하는 경향이 있기 때문에 항암치료의 효과보다 부작용이 더 크게 나타난다면 의료진은 항암제의 투여 용량을 조정하거나 약물을 변경 혹은 중단 하는 등의 조치를 취하게 된다. 이러한 문제점을 해결하고 궁극적으로 항암효과를 높이기 위해 새로운 항암제 개발이나 기존에 사용하던 항암제의 병용투여에 대한 연구가 지속적으로 이루어지고 있다.
	한의학에서 사용하는 항암 치료용 한약들이 효과가 있을지라도 서양의학의 항암 치료시 금지되는 이유는 무엇인가?	그러나 항암제와 한약 각각의 약물이 효과적이라고 해도 약물상호작용으로 인해 오히려 항암제의 효과를 저해하거나 부작용을 유발할 가능성이 있기 때문에 항암 치료 중 한약 복용을 금지시키는 경우가 대부분 이다. 설문연구에 따르면 협진이 이루어지고 있는 2 개소 한방병원에서 암환자의 한약 병용투여율은 각각 38.
	서양의학에서의 암 치료법은 무엇이 있는가?	서양의학에서의 암 치료법은 외과처치, 방사선요법, 화학요법, 호르몬요법, 면역요법 등이 사용되고 있지만 그에 수반되는 부작용과 한계점으로 보다 효과적이고 부작용이 적은 치료방법이 요구된다. 특히 항암화학 요법의 경우 일반적으로 치료 횟수가 증가할수록 부작용이 증가하는 경향이 있기 때문에 항암치료의 효과보다 부작용이 더 크게 나타난다면 의료진은 항암제의 투여 용량을 조정하거나 약물을 변경 혹은 중단 하는 등의 조치를 취하게 된다.

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