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NTIS 바로가기한국유화학회지 = Journal of oil & applied science, v.35 no.4, 2018년, pp.1369 - 1378
정갑섭 (동명대학교 식품영양학과) , 노정숙 (동명대학교 식품영양학과)
The purpose of this study was to investigate the effect of skate skin collagen peptide (SCP) according to its molecular weight (1,000 Da) which was divided using the ultrafilatration method. The 200 mg/kg collagen peptide was administrated to obesity-induced db/db mice for 8 weeks. As the results, i...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
콜라겐(collagen)은 무엇인가? | 콜라겐(collagen)은 결합조직의 주성분이며 주로 뼈와 피부에 존재하고, 그 외에 관절, 각 장기의 막 등 동물조직 전체에 분포되어 있는 성분이 며, 최근 식품과 의약품 소재로 널리 사용되고 있다[7]. 생리 기능성을 가지는 활성 콜라겐 펩타 이드는 단백질 분해효소에 의해 가수분해하여 얻어진다. | |
활성산소종은 무엇을 일으키는 가? | 체내에 지질 또는 혈당의 증가는 이들의 대사과정이 활성화되며, 이러한 과정 중 활성산소(reactive oxygen species, ROS)의 생성이 크게 증가한다. 이러한 활성산소종은 생체에 치명적인 산소독성을 일으키며 세포막 분해, 단백질 분해, 지질 산화, DNA 변성 등을 초래하여 세포의 기능장애를 유발하고 암을 비롯한 뇌졸중, 파킨슨 병 등의 뇌질환과 심장질환, 동맥경화, 염증, 노화 등의 각종 질병을 일으키는 것으로 알려져 있다[3-5]. 과도한 활성산소의 생성이 이를 제거하는 항산화 시스템의 작용보다 클 경우, 산화적 스트레스가 발생하게 된다. | |
비만 유발 실험동물인 db/db mice에 체중당 200 mg의 홍어 껍질 유래 콜라겐 펩타이드를 8주간 투여했을 때 체중변화는 어떻게 나타나는 가? | 1. 콜라겐 펩타이드 투여군에서 최종 체중은 비만대조군에 비해 낮았으며, 체중 증가량이 감소하였다. |
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