[논문]기침에 대한 반하사심탕의 효과 : 체계적인 문헌고찰과 메타분석

한승희; 선승호

doi:10.22246/jikm.2021.42.3.385

기침에 대한 반하사심탕의 효과 : 체계적인 문헌고찰과 메타분석
The Effect of Banhasasim-tang in Cough: A Systematic Review and Meta-analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.3, 2021년, pp.385 - 402

한승희 (상지대학교부속한방병원 한방내과) , 선승호 (상지대학교부속한방병원 한방내과)

Abstract ▼ AI-Helper

Objective: This study confirms the safety and efficacy of Banhasasim-tang (BST) against cough through systematic review and meta-analysis. Methods: PubMed, Cochrane, ScienceDirect, Wiley online library, OASIS, KISS, NDSL, RISS, Science and Technology Society Village, DBpia, CNKI, J-STAGE, and CiNii were used as search engines. The search period was from the start of search engine support to June 30. 2020. And search language was not limited. Cochrane's risk of bias (RoB) tool was used to evaluate the quality of the studies. A meta-analysis of the total effective rate (TER), cough symptom score, and spirometry results was performed using the Review Manager program. Results: 6 studies were finally selected. The group using BST showed significant symptom relief, as the odds ratio (OR) value of TER was 5.56 times higher (95% CI: 3.50, 8.82, P<0.0001) compared to the control groups. The reported adverse effects did not occur in the intervention group. In addition, the cough symptom score and spirometry results showed that BST was more effective than Western medicine alone. Conclusion: BST can be expected to relieve cough, and it can be applied to chronic cough that is not treated with existing treatments. However, due to the low quality of the selected articles, additional high-quality RCTs will be required in the future.

주제어

표/그림 (11)

그림 Fig. 1. Prisma flow diagram for process of literature search.
표 Table 1. Characteristics of Randomized Controlled Trials Included in the Meta-Analysis
그림 Fig. 2. Risk of bias graph.
그림 Fig. 3. Summary of risk of bias.
그림 Fig. 4. Funnel plot for the outcome of effective rate.
그림 Fig. 5. Results of meta-analysis for total effective rate (BST vs WM). BST : Banhasasim-tang, WM : Western medicine
그림 Fig. 6. Results of meta-analysis for total effective rate (only BST vs WM). BST : Banhasasim-tang, WM : Western medicine
그림 Fig. 7. Results of meta-analysis for total effective rate (BST+WM vs WM). BST : Banhasasim-tang, WM : Western medicine
그림 Fig. 8. Results of meta-analysis for total effective rate (BST vs CPOS). BST : Banhasasim-tang, CPOS : Codeine phosphate oral solution
그림 Fig. 9. Results of meta-analysis for total effective rate (chronic cough patient). BST : Banhasasim-tang, WM : Western medicine
그림 Fig. 10. Results of meta-analysis for cough symptom score. BST : Banhasasim-tang, WM : Western medicine

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