[논문]건성안 증후군에 대한 전자뜸과 침의 효과 비교 임상연구

박지식; 송지훈; 정민영; 최정화; 박수연

doi:10.6114/jkood.2023.36.1.064

건성안 증후군에 대한 전자뜸과 침의 효과 비교 임상연구
A Comparative Clinical Study on an Electronic Moxibustion with Acupuncture for Dry Eye Syndrome 원문보기

韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.36 no.1, 2023년, pp.64 - 77

박지식 (동신대학교 한의과대학 한방안이비인후피부과학교실) , 송지훈 (동신대학교 한의과대학 한방안이비인후피부과학교실) , 정민영 (동신대학교 한의과대학 한방안이비인후피부과학교실) , 최정화 (동신대학교 한의과대학 한방안이비인후피부과학교실) , 박수연 (동신대학교 한의과대학 한방안이비인후피부과학교실)

Abstract ▼ AI-Helper

Objectives : Recently, the number of patients with dry eye syndrome has been steadily increasing. However, established treatment for it does not yet exist. This study compared electronic moxibustion with acupuncture for patients with dry eye in terms of efficacy and safety. Methods : This trial was designed as an investigator-initiated, single-blinded, comparative, randomized controlled trial. Thirty patients with dry eye were randomized to the electronic moxibustion treatment group(EMG) or the acupuncture treatment group(AG) in equal proportion. The participants who assigned to the EMG were treated with electronic moxibustion to ten acupoints including both sides of BL2, GB14, TE23, and LI4 for 12 minutes. The participants who were assigned to the AG were treated with acupuncture to the same acupoints for 15 minutes. Over 4 weeks, each intervention was carried out twelve times in total. The primary outcome was the ocular surface disease index(OSDI). The secondary outcomes were the subjective symptoms visual analog scale(VAS), quality of life(QoL), Schirmer I test(SIT), and general assessment. Adverse events and vital signs were also investigated for safety assessment. Results : In intragroup comparisons, both the EMG and the AG significantly improved the OSDI scores, the subjective symptoms VAS scores, the QoL scores, and the SIT results after 4 weeks of the trial. However, there were no statistical differences in intergroup comparisons between the two groups after 4 weeks. The safety of electronic moxibustion and acupuncture was confirmed by no occurrence of serious adverse events. Conclusions : Both electronic moxibustion and acupuncture were effective for dry eye syndrome, and they were safe. Electronic moxibustion and acupuncture can be used for dry eye syndrome as equivalent treatments.

주제어

표/그림 (9)

표 Table 1. The OSDI Questionnaire
표 Table 2. Criteria for General Assessment
그림 Fig. 1. The Flow Diagram of the Study At first, thirty patients were enrolled in. They were randomly allocated into the EMG and the AG in equal proportion. After finishing the trial, all participants were analyzed in the final assessment with no dropouts. EMG: electronic moxibustion treatment group, AG: acupuncture treatment group, ITT: intention-to-treat, and PP: per protocol
그림 Fig. 2. Changes in the OSDI Score Both interventions significantly decreased the OSDI score after 2 and 4 weeks. However, there was no statistical significance in intergroup comparisons after 2 and 4 weeks. ^†: p<0.05 on comparing the result after 2 weeks with the baseline, and ^‡: p<0.05 on comparing the result after 4 weeks with the baseline. OSDI: ocular surface disease index, EMG: electronic moxibustion treatment group, and AG: acupuncture treatment group
표 Table 3. General Characteristics of the Participants
그림 Fig. 3. Changes in the VAS Score for Subjective Symptoms Both interventions significantly decreased the VAS score after 2 and 4 weeks. However, there was no statistical significance in intergroup comparisons after 2 and 4 weeks. ^†: p<0.05 on comparing the result after 2 weeks with the baseline, and ^‡: p<0.05 on comparing the result after 4 weeks with the baseline. VAS: visual analog scale, EMG: electronic moxibustion treatment group, and AG: acupuncture treatment group
그림 Fig. 4. Changes in the QoL Score Both interventions significantly improved the QoL after 2 and 4 weeks. However, there was no difference in intergroup comparisons after 2 and 4 weeks. *: p<0.05 on comparing the result between the EMG and the AG, ^†: p<0.05 on comparing the result after 2 weeks with the baseline, and ^‡: p<0.05 on comparing the result after 4 weeks with the baseline. QoL: quality of life, EMG: electronic moxibustion treatment group, and AG: acupuncture treatment group
그림 Fig. 5. Changes in Lacrimation Measured by the SIT Both interventions significantly increased tear secretion after 4 weeks. The increase in the EMG was higher than that of the AG in both eyes. However, there was no statistical significance in intergroup comparison. (A) The SIT result of the left eye. (B) The SIT result of the right eye. *: p<0.05 on comparing the result between the EMG and the AG, and ^†: p<0.05 on comparing the result after 4 weeks with the baseline. SIT: Schirmer Ⅰ test, EMG: electronic moxibustion treatment group, and AG: acupuncture treatment group
표 Table 4. General Assessment Results on the Final Visit

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