[논문]The roles of growth factors and hormones in the regulation of muscle satellite cells for cultured meat production

Syed Sayeed Ahmad; Hee Jin Chun; Khurshid Ahmad; Sibhghatulla Shaikh; Jeong Ho Lim; Shahid Ali; Sung Soo Han; Sun Jin Hur; Jung Hoon Sohn; Eun Ju Lee; Inho Choi

doi:10.5187/jast.2022.e114

The roles of growth factors and hormones in the regulation of muscle satellite cells for cultured meat production 원문보기

Journal of animal science and technology : JAST, v.65 no.1, 2023년, pp.16 - 31

Syed Sayeed Ahmad (Department of Medical Biotechnology, Yeungnam University) , Hee Jin Chun (Department of Medical Biotechnology, Yeungnam University) , Khurshid Ahmad (Department of Medical Biotechnology, Yeungnam University) , Sibhghatulla Shaikh (Department of Medical Biotechnology, Yeungnam University) , Jeong Ho Lim (Department of Medical Biotechnology, Yeungnam University) , Shahid Ali (Department of Medical Biotechnology, Yeungnam University) , Sung Soo Han (Research Institute of Cell Culture, Yeungnam University) , Sun Jin Hur (Department of Animal Science and Technology, Chung-Ang University) , Jung Hoon Sohn (Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) , Eun Ju Lee (Department of Medical Biotechnology, Yeungnam University) , Inho Choi (Department of Medical Biotechnology, Yeungnam University)

Abstract ▼ AI-Helper

Cultured meat is a potential sustainable food generated by the in vitro myogenesis of muscle satellite (stem) cells (MSCs). The self-renewal and differentiation properties of MSCs are of primary interest for cultured meat production. MSC proliferation and differentiation are influenced by a variety of growth factors such as insulin-like growth factors (IGF-1 and IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGF-2 and FGF-21), platelet-derived growth factor (PDGF) and hepatocyte growth factor (HGF) and by hormones like insulin, testosterone, glucocorticoids, and thyroid hormones. In this review, we investigated the roles of growth factors and hormones during cultured meat production because these factors provide signals for MSC growth and structural stability. The aim of this article is to provide the important idea about different growth factors such as FGF (enhance the cell proliferation and differentiation), IGF-1 (increase the number of myoblasts), PDGF (myoblast proliferation), TGF-β1 (muscle repair) and hormones such as insulin (cell survival and growth), testosterone (muscle fiber size), dexamethasone (myoblast proliferation and differentiation), and thyroid hormones (amount and diameter of muscle fibers and determine the usual pattern of fiber distributions) as media components during myogenesis for cultured meat production.

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표/그림 (2)

그림 Fig. 1. Cultured meat production based on myogenesis. MSC isolated from selected animals through biopsy or from animal tissues have different proliferation and differentiation properties. The roles of different growth and muscle regulatory factors during myogenesis are also included in the figure. FGF2, HGF, and IGF-1 enhance cell proliferation, and FGF21 aids myotube formation. FGF, fibroblast growth factor; HGF, hepatocyte growth factor; IGF, insulin-like growth factors; MSC, muscle satellite (stem) cel.
표 Table 1. Growth factors, hormones, and other supplements and their functions during myogenesis and cultured meat production. Several GFs (IGFs, insulin, TGF-β, FGF, PDGF, and HGF) and hormones (thyroid hormones, testosterone, and glucocorticoids) and other supplements (heme proteins, transferrin, BMP, and mTOR) and their functions during cultured meat production and myogenesis are mentioned

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후속연구

Technical difficulties related to culture media, such as GF, hormones, identification of animals (age and health), sampling of MSCs, consumer acceptance, and religious standpoints, pose considerable challenges to the establishment of viable large-scale in vitro meat production systems, and thus, more research is required before this meat culturing system can be implemented at industrial levels.

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표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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