[논문]SARS-CoV, MERS-CoV, and 2019-nCoV viruses: an overview of origin, evolution, and genetic variations

Krishnamoorthy, Sarayu; Swain, Basudev; Verma, R. S.; Gunthe, Sachin S.

doi:10.1007/s13337-020-00632-9

[해외논문] SARS-CoV, MERS-CoV, and 2019-nCoV viruses: an overview of origin, evolution, and genetic variations 원문보기

Virusdisease, v.31 no.4, 2020년, pp.411 - 423

Krishnamoorthy, Sarayu (EWRE Division, Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, 600 036 India) , Swain, Basudev (EWRE Division, Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, 600 036 India) , Verma, R. S. (Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600 036 India) , Gunthe, Sachin S. (EWRE Division, Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, 600 036 India)

Abstract ▼ AI-Helper

Coronaviruses are single stranded RNA viruses usually present in bats (reservoir hosts), and are generally lethal, highly transmissible, and pathogenic viruses causing sever morbidity and mortality rates in human. Several animals including civets, camels, etc. have been identified as intermediate hosts enabling effective recombination of these viruses to emerge as new virulent and pathogenic strains. Among the seven known human coronaviruses SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV) have evolved as severe pathogenic forms infecting the human respiratory tract. About 8096 cases and 774 deaths were reported worldwide with the SARS-CoV infection during year 2002; 2229 cases and 791 deaths were reported for the MERS-CoV that emerged during 2012. Recently ~ 33,849,737 cases and 1,012,742 deaths (data as on 30 Sep 2020) were reported from the recent evolver SARS-CoV-2 infection. Studies on epidemiology and pathogenicity have shown that the viral spread was potentially caused by the contact route especially through the droplets, aerosols, and contaminated fomites. Genomic studies have confirmed the role of the viral spike protein in virulence and pathogenicity. They target the respiratory tract of the human causing severe progressive pneumonia affecting other organs like central nervous system in case of SARS-CoV, severe renal failure in MERS-CoV, and multi-organ failure in SARS-CoV-2. Herein, with respect to current awareness and role of coronaviruses in global public health, we review the various factors involving the origin, evolution, and transmission including the genetic variations observed, epidemiology, and pathogenicity of the three potential coronaviruses variants SARS-CoV, MERS-CoV, and 2019-nCoV.Electronic supplementary materialThe online version of this article (10.1007/s13337-020-00632-9) contains supplementary material, which is available to authorized users.

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116. Zhou P Yang X-L Wang X-G A pneumonia outbreak associated with a new coronavirus of probable bat origin Nature 2020 579 270 3 10.1038/s41586-020-2012-7 32015507

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117. Ziad AM Nischay M Kevin JO Middle east respiratory syndrome coronavirus in bats, Saudi Arabia Emerg Infect Dis J 2013 19 1819 10.3201/eid1911.131172

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118. Zumla A Hui DS Perlman S Middle East respiratory syndrome Lancet 2015 386 995 1007 10.1016/S0140-6736(15)60454-8 26049252

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활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
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표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
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