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Abstract AI-Helper 아이콘AI-Helper

In this study, we investigated the therapeutic effects of a novel formulation of low-dose calcium and vitamin $D_3$ blended with Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max (RE+), in postmenopausal women. The controls were given either a placebo or high dose calcium and...

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대상 데이터

  • After being imported by the Poongsan Pharmaceutical Company, alcohol was added and processed in steam. Eleutherococcus senticosus (Araliaceae), widely distributed by China (East-North province), was obtained in the fall and also imported by the Poongsan Pharmaceutical Company. The marker substance, 5-HMF (5-(Hydroxymethyl)-2-furaldehyde}, was used for RGX, and Eleutheroside E {(— )-Syringaresinol-4-4'-O- /9-D-Diglucoside} was used for ES.
  • Potential subjects were screened initially by interview to ensure that they were postmenopausal women who were free of chronic diseases, such as known cardiovascular disease, diabetes mellitus, or malignant tumors and previous pathological fractures, and who had a body mass index (BMI; in kg/m2) between 20 and 30. Sixty-seven women were initially recruited, and 41 women were finally enrolled. We randomly assigned the participants to one of three groups.
  • The 41 participants were randomly assigned to one of three groups: RE + , Ca + D, and placebo, resulting in 14, 14, and 13 volunteers, respectively. The BMD and biochemical markers were assessed at the beginning (TO), and at 6 (T6) and 12 months (T12) after administration of the supplements.
  • We randomly assigned the participants to one of three groups. The women enrolled in the study were between 51 and 71 years old, had been postmenopausal for at least three years, and had osteopenia or osteoporosis having lumbar spine BMDs greater than 1.0 SD, below the young adult mean (T-score < —1.0) (WHO, 1994). Subjects who had conditions affecting bone metabolism, such as kidney, liver, parathyroid, and thyroid disease were excluded from the study.

데이터처리

  • RE + : formulation of calcium and vitamin D3, blended with Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max. Data art mean of BMD change ±SD, ap<0.05 compared with TO with paired t-test, bp<0.05 compared with placebo group with ANOVA. There were significant differences in the changes between placebo and RE+ groups by repetitive-measured ANOVA (p<0.
  • Data were presented as mean±SD. Mean differences in each group were avaluated by a student's t-test for paired samples. Percenlage changes in BMD and biochemical markers were calculated [(post-treatment-baseline values)/ baseline valuesX 100] for each group.
  • The BMD of the lumbar spine gradually declined in the placebo group, but it increased in the RE+ and Ca + D groups. The change in the RE+ at T6 was significant with TO by the paired t-test (p < 0.05) and compared with the placebo group by ANOVA (p<0.05). The BMD of the femur declined in the placebo group; the BMD increased in the RE + and Ca + D groups, however, a significant treatment effect was found in T6 and T12, only in the RE + group with TO by the paired t-test (p<0.
  • Percenlage changes in BMD and biochemical markers were calculated [(post-treatment-baseline values)/ baseline valuesX 100] for each group. To determine whether the changes over the course of treatment were significantly different from the baseline in each group, paired t-tests were performed. The repetitive-measured analysis of variance (ANOVA) was used to detect differences in the changes recordec.
  • RE + : formulation of calcium and vitamin D3, blended with Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max. Data art mean of BMD change ±SD, ap<0.05 compared with TO with paired t-test, bp<0.05 compared with placebo group with ANOVA. There were significant differences in the changes between placebo and RE+ groups by repetitive-measured ANOVA (p<0.

이론/모형

  • All three markers were measured at the baseline and 6 and 12 months after treatment by using the competitive enzyme-linked inimunosorbant assay (ELISA). Baseline serum calcium, phosphate, creatinine, and total alkaline phosphatase levels were also determined by routine methods employing an autoanalyzer (Shimadzu CL-7200, Shimadzu Co.
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