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NTIS 바로가기한국식품과학회지 = Korean journal of food science and technology, v.42 no.4 = no.212, 2010년, pp.488 - 493
고정아 (고려대학교 생명공학부) , 임헌선 ((주)한국메디) , 김건희 (덕성여자대학교 식품영양학과) , 박지용 (연세대학교 생명공학과) , 한찬규 (한국식품연구원) , 박현진 (고려대학교 생명공학부)
We investigated the effect of Perilla frutescens (PF) ethanol extract powder (PF-E30) on the local allergic reaction activated by anti-DNP IgE and the mast cell-mediated immediate-type allergic reactions induced by compound 48/80 in a mouse model. One gram of PF powder extracted with 30% ethanol at ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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소엽추출물을 이용한 마우스 모델 실험에서 알수 있는 점은? | acuta Kudo(Labiatae)로, 전통적인 한방 소재로서 기침을 동반한 감기, 구토 및 기관지 천식을 치료하는데 사용되고 있다(4). 마우스 모델 실험에서 소엽추출물의 복강 내 주사는 항원-특이성 IgE(antigen-specific IgE) 생산과 복강 비만세포(mast cell)로부터 히스타민 방출을 억제시켰으며, 이는 소엽의 알레르기 저해 활성을 시사한다고 할 수 있다(5,6). Makino 등(7)은 로즈마린산(rosmarinic acid)이 소엽추출물의 항증진 효과를 나타내는 대표물질 중 하나라고 하였고 비만세포는 화학적 매개자를 방출함으로써 알레르겐에 대응하는 즉시형 알레르기 반응(immediate type allergic reactions)을 유발하는 것으로 현재 입증되어 있다(8). | |
차조기 추출물에 대한 Makino 등의 연구 결과는? | 마우스 모델 실험에서 소엽추출물의 복강 내 주사는 항원-특이성 IgE(antigen-specific IgE) 생산과 복강 비만세포(mast cell)로부터 히스타민 방출을 억제시켰으며, 이는 소엽의 알레르기 저해 활성을 시사한다고 할 수 있다(5,6). Makino 등(7)은 로즈마린산(rosmarinic acid)이 소엽추출물의 항증진 효과를 나타내는 대표물질 중 하나라고 하였고 비만세포는 화학적 매개자를 방출함으로써 알레르겐에 대응하는 즉시형 알레르기 반응(immediate type allergic reactions)을 유발하는 것으로 현재 입증되어 있다(8). 비만세포의 과립소실(degranulation)은 뚜렷한 히스타민 방출을 일으키는 compound 48/80이나 과민반응(anaphylactic reactions)과 관련된 다른 화학적 매개자와 같은 비면역학적 분비 촉진제(non-immunologic secretagogues)에 의하여 유발된다(9,10). | |
소엽은 한방에서 어떤 병을 치료하기 위해 사용되는가? | Britton var. acuta Kudo(Labiatae)로, 전통적인 한방 소재로서 기침을 동반한 감기, 구토 및 기관지 천식을 치료하는데 사용되고 있다(4). 마우스 모델 실험에서 소엽추출물의 복강 내 주사는 항원-특이성 IgE(antigen-specific IgE) 생산과 복강 비만세포(mast cell)로부터 히스타민 방출을 억제시켰으며, 이는 소엽의 알레르기 저해 활성을 시사한다고 할 수 있다(5,6). |
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