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NTIS 바로가기Journal of applied biological chemistry, v.57 no.4, 2014년, pp.379 - 386
강한철 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) , 김종범 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) , 노경희 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) , 김현욱 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) , 이경렬 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) , 김순희 (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration)
Chromatin is an instructive DNA structure that can widely respond to external signals. An important change of chromatin is the modifications of histone for this regulation. There are accumulating lists of these modifications and the complexity of their action is gradually understood. It is evident t...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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크로마틴이란 무엇인가? | 크로마틴은 DNA 구조를 다시 결정해주는 것과 같은 존재로 각종 신호에 폭넓게 반응한다. 크로마틴의 중요한 변화는 이러한 조절을 위한 히스톤의 변이이다. | |
히스톤 변이는 chromatin을 재구성하는 효소들의 집합에 관여할 때 어떤 에너지를 사용하는가? | 히스톤 변이는 chromatin의 구조 조절에 관여하는 역할 이외에도 chromatin을 재구성하는 효소들의 집합에도 관여를 한다(Bannister와 Kouzarides, 2011). 이러한 경우에 효소들은 nucleosome을 재구성하기 위하여 ATP 를 분해시킨 에너지를 사용하게 된다. | |
히스톤의 변화의 역할은 무엇인가? | 이러한 변화들에 대한 지식이 점점 축적되고 있으며 이러한 반응의 복잡성이 점점 더 명확히 이해되고 있다. 히스톤의 변화가 대부분의 생명체의 반응에 있어서 DNA 의 발현 또는 억제를 통하여 중요한 역할을 한다는 사실이 명확해지고 있다. Nucleosome 의 표면은 각종 변화를 수용할 수 있다. |
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