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NTIS 바로가기한국식품저장유통학회지 = Korean journal of food preservation, v.24 no.7, 2017년, pp.1025 - 1033
In this study, Ledum palustre L. was extracted by 4 different methods (LPW, hot water extraction; LPA, autoclave extraction; LPU, ultrasonification extraction; LPE, 70% ethanol extraction) and LPE was fractionated by using polarity difference of each solvent and used as 4 samples (LPE/H, the n-hexan...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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활성산소의 성질은? | 따라서 이에 대한 연구 개발이 활발해졌으며, 항산화와 항염효과 등의 활성성분 발견을 위한 근거 중심적 연구가 활발하게 진행되고 있다(2-4). 활성산소는 대부분 불안정하여 전자를 잃거나 얻어서 보다 안정된 상태로 가려는 성질이 있으며 이들의 높은 반응성은 생체내에서 산화적손상을 일으킨다(5). 생체의 산화반응 과정 중에 생성되는 활성산소들은 체내의 superoxide dismutase, catalase,glutathione peroxidase와 같은 항산화효소에 의해 제거되지만, reactive oxygen species(ROS)는 지질과산화, 단백질산화, 단백질 분해효소의 활성화, DNA산화와 같은 손상을야기한다(6). | |
DNA산화의 결과로 나타나는 질환은 무엇인가? | 생체의 산화반응 과정 중에 생성되는 활성산소들은 체내의 superoxide dismutase, catalase,glutathione peroxidase와 같은 항산화효소에 의해 제거되지만, reactive oxygen species(ROS)는 지질과산화, 단백질산화, 단백질 분해효소의 활성화, DNA산화와 같은 손상을야기한다(6). 이러한 손상의 결과로 고혈압, 당뇨병, 아토피성 피부염, 류마티스 관절염과 같은 염증성 질환이 발생하게 된다(7-9). 이와 같은 과량의 ROS로 인한 산화적 스트레스가 항산화물질에 의해 감소되는 것이 알려지면서 항산화 물질을 개발하기 위한 연구들이 지속적으로 이루어지고 있으며, 합성 항산화제의 부작용이 증가함에 따라 천연물 유래의 항산화제에 관한 연구가 더욱 활발히 진행되고 있다(10). | |
생체의 산화반응 과정으로 인해 생성되는 활성산소를 제거하는 효소는 무엇인가? | 활성산소는 대부분 불안정하여 전자를 잃거나 얻어서 보다 안정된 상태로 가려는 성질이 있으며 이들의 높은 반응성은 생체내에서 산화적손상을 일으킨다(5). 생체의 산화반응 과정 중에 생성되는 활성산소들은 체내의 superoxide dismutase, catalase,glutathione peroxidase와 같은 항산화효소에 의해 제거되지만, reactive oxygen species(ROS)는 지질과산화, 단백질산화, 단백질 분해효소의 활성화, DNA산화와 같은 손상을야기한다(6). 이러한 손상의 결과로 고혈압, 당뇨병, 아토피성 피부염, 류마티스 관절염과 같은 염증성 질환이 발생하게 된다(7-9). |
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