Objectives: The aim of this study was to perform a meta analysis of randomized controlled trials (RCTs) that applied Opae-san to peptic ulcer. Methods: The databases NDSL, RISS, KISS, KISTI, Oasis, DBpia, Cochrane, EMBASE, Pubmed, and CNKI were searched to identify RCTs that evaluated the therapeutic response to Opae-san on peptic ulcer. The selected studies were assessed using Cochrane Group's risk of bias tool. Results: 12 RCTs were selected from a total of 312 identified. Combined therapies of Opae-san plus triple therapy were superior to only triple therapy in achieving the effective rate (risk ratio=1.26, 95% CI: 1.17 to 1.35, p<0.001, I2=0%), the helicobacter pylori eradication rate (risk ratio=1.23, 95% CI: 1.12 to 1.34, p<0.001, I2=7%) and the recurrence rate (risk ratio=0.31, 95% CI: 0.12 to 0.82, p=0.02, I2=0%). But only Opae-san was not superior in achieving the effective rate compared to anti gastric secretion drugs. Conclusions: The current evidence suggests that combined therapies of Opae-san plus triple therapy yield a higher effective rate, and helicobacter pylori eradication rate and a lower recurrence rate. However, in most of these studies, it is difficult to evaluate the bias and therefore better designed studies are needed.
헬리코박터 제균치료 및 제산제, 히스타민 제 2형 수용체 길항체, 양성자 펌프 억제제 등의 치료제가 사용
전형적인 증상은 상복부 불쾌감, 더부룩함, 상복부 통증, 속쓰림 등으로 나타나며, 합병증으로는 출혈, 천공, 폐쇄 등이 있다5. 현재 시행되는 치료로는 헬리코박터 제균치료 및 제산제, 히스타민 제 2형 수용체 길항체, 양성자 펌프 억제제 등의 치료제가 사용되며, 일반적인 치료기간은 4주에서 8주 정도이다6.과거에 비해 소화성 궤양의 치료가 꾸준히 발전되어 왔지만 고령화로 인한 동반질환의 증가로 합병증으로 인한 사망률은 약간 감소할 뿐 여전히 높다.
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