$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

뽕잎 추출물 기원 Flavonoid Rich Fraction의 항비만효과
Anti-obesity Effect of the Flavonoid Rich Fraction from Mulberry Leaf Extract 원문보기

韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.28 no.6, 2020년, pp.395 - 411  

고은지 (강원대학교 바이오헬스융합학과) ,  류병렬 (강원대학교 바이오헬스융합학과) ,  양수진 (강원대학교 생약자원개발학과) ,  백종섭 (강원대학교 바이오헬스융합학과) ,  유수지 (강원대학교 바이오헬스융합학과) ,  김현복 (농촌진흥청 국립농업과학원) ,  임정대 (강원대학교 바이오헬스융합학과)

Abstract AI-Helper 아이콘AI-Helper

Background: This study investigated the anti-obesity effect of the flavonoid rich fraction (FRF) and its constituent, rutin obtained from the leaf of Morus alba L., on the lipid accumulation mechanism in 3T3-L1 adipocyte and C57BL/6 mouse models. Methods and Results: In Oil Red O staining, FRF (1,00...

주제어

참고문헌 (42)

  1. Ahn J, Lee H, Kim S, Park J and Ha T. (2008). The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochemical and Biophysical Research Communications. 373:545-549. 

  2. Ali AT, Hochfeld WE, Myburgh R and Pepper MS. (2013). Adipocyte and adipogenesis. European Journal of Cell Biology. 92:229-236. 

  3. Alihaid G, Grimaldi P and Negrel R. (1992). Cellular and molecular aspects of adipose tissue development. Annual Review of Nutrition. 12:207-233. 

  4. Ann JY, Eo H and Lim Y. (2015). Mulberry leaves(Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high fat diet-fed mice. Genes Nutrition. 10:1-13. 

  5. Arcri DP, Bartchewsky W, dos Santos TW, Oliveira KA, Funck A, Pedrazzoli J, de Souza MF, Saad MJ, Bastos DH, Gambero A, Carvalho Pde O and Ribeiro ML. (2009). Antiobesity effects of yerba mateextract(Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity. 17:2127-2133. 

  6. Attila H, Katalin V, Danko B, Zoltan K, Edit W, Anasztasia H, Istvan Z and Yusty-Jouan H. (2013). In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract. Phytotherapy Research. 27:847-851. 

  7. Bartchewsky W, Tanila W, Oliveira K, Deoliveira CC, Gotardo EM, Pedrazzoli J Jr, Gambero A, Ferraz LF, Carvalho Pde O and Ribeiro ML. (2011). Anti-inflammatory effects of yerba mate extract(Ilex paraguariensis) ameliorate insulin resistance in mice with high fat dietinduced obesity. Molecular and Cellular Endocrinology. 335:110-115. 

  8. Boney AM, Moats-ataats BM, Stiles AD and Dercole AJ. (1994). Expression of insulin-like growth factor-I(IGF-1) and IGF-binding proteins during adipogenesis. Endocrinology. 135: 1863-1868. 

  9. Cannon B and Nedergaard J. (2004). Brownadipose tissue: Function and physiological significance. Physiological Rev. 84:277-359. 

  10. Choi I, Park Y, Choi H and Lee EH. (2006). Anti-adipogenic activity of rutin in 3T3-L1 cells and mice fed with high-fat diet. BioFactors. 26:273-281. 

  11. Emamat H, Nouri M, Foroughi F, Rismanchi M, Eini-Zinab H and Hekmatdoost A. (2016). An accessible and pragmatic experimental model of nonalcoholic fatty liver disease. Middle East Journal of Digestive Diseases. 8:109-115. 

  12. Fu Y, Luo N, Klein RL and Garvey WT. (2005). Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. Journal of Lipid Research. 46:1369-1379. 

  13. Han MH, Kim HJ, Jeong JW, Park C, Kim BW and Choi YH. (2018). Inhibition of adipocyte differentiation by anthocyanins isolated from the fruit of Vitis coignetiae Pulliat is associated with the activation of AMPK signaling pathway. Toxicological Research. 34:13-21. 

  14. Hwang JY, Wu YX, Hwang DI, Bae SJ and Kim T. (2014). Anti-obesity effect of Polygala tenuifolia. Korean Journal of Food Preservation. 21:97-106. 

  15. Jayarathne S, Koboziev I, Park OH, Oldewage-Theron W, Shen CL and Moustaid-Moussa N. (2017). Anti-inflammatory and anti-obesity properties of food bioactive components: Effects on adipose tissue. Preventive Nutrition and Food Science. 22:251-262. 

  16. Kajimura S, Spiegelman BM and Seale P. (2015). Brown and beige fat: Physiological roles beyond heat generation. Cell Metabolism. 22:546-559. 

  17. Khalilpourfarshbafi M, Gholami K, Murugan DD, Sattar MZA and Abdullah NA. (2019). Differential effects of dietary flavonoids on adipogenesis. European Journal of Nutrition. 58:5-25. 

  18. Kim GS, Park HJ, Woo JH, Kim MK, Koh PO, Min W, Ko YG, Kim CH, Won CK and Cho JH. (2012). Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC Complement. Alternative Medicine. 12:31. 

  19. Kim HB, Seo SD, Koo HY, Seok YS, Kim SL and Sung GB. (2013). Quantitative analysis of 1-deoxynojirimycin in mulberry leaves. Journal of Sericultural and Entomological Science. 51:20-29. 

  20. Kim JE and Chen J. (2004). Regulation of peroxisome proliferatoractivated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes. 53:2748-2756. 

  21. Kim KH. (1997). Regulation of mammalian acetyl-coenzyme a carboxylase. Annual Review of Nutrition. 17:77-99. 

  22. Kim SK, Kim SY, Kim HJ and Kim AJ. (2001). The effect of mulberry-leaf extract on the body fat accumulation in obese fa/fa male zucker rats. Journal of the Korean Society of Food Science and Nutrition. 30:516-520. 

  23. Lefterova MI and Lazar MA. (2009). New developments in adipogenesis. Trends in Endocrinology and Metabolism. 20:107-114. 

  24. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ, Liu XS and Lazar MA. (2008). PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes and Development. 22:2941-2952. 

  25. Lowell BB and Spiegelman BM. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature. 404:652-660. 

  26. Maratos-Flier E. (2008). The long reach of leptin. Nature Medicine. 14:604-606. 

  27. Mattews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC. (1985). Hemeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetolodia. 282: 412-419. 

  28. Prince PS and Kamalakkannan N. (2006). Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. Journal of Biochemical and Molecular Toxicology. 20:96-102. 

  29. Rosenbaum M and Leibel RL. (1999). clinical review 107: Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. Journal of Clinical Endocrinology and Metabolism. 84:1784-1789. 

  30. Rucker D, Padwal R, Li SK, Curioni C and Lau DC. (2007). Long term pharmacotherapy for obesity and overweight: Updated metanalysis. British Medical Journal. 335:1194-1199. 

  31. Samuel Wu YH, Chiu CH, Yang DJ, Lin YL, Tseng JK and Chen YC. (2013). Inhibitory effects of litchi(Litchi chinensis Sonn.) flower-water extracts on lipase activity and diet-induced obesity. Journal of Functional Foods. 5:923-929. 

  32. Schmid B, Rippmann JF, Tadayyon M and Hamilton BS. (2005). Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochemical and Biophysical Research Communications. 328:1073-1082. 

  33. Skurk T, Alberti-Huber C, Herder C and Hauner H. (2007). Relationship between adipocyte size and adipokine expression and secretion. Journal of Clinical Endocrinology and Metabolism. 92:1023-1033. 

  34. Song Y, Park HJ, Kang SN, Jang SH, Lee SJ, Ko YG, Kim GS and Cho JH. (2013). Blueberry peel extracts inhibit adipogenesis in 3T3-L1 cells and reduce high-fat diet-induced obesity. PLoS ONE. 8:e69925. 

  35. Spiegelman BM and Flier JS. (1996). Adipogenesis and obesity: Rounding out the big picture. Cell. 87:377-389. 

  36. Tao Y and Zhang Y. (2013). Rapid screening and identification of glucosidase inhibitors from mulberry leaves using enzyme immobilized magnetic beads coupled with HPLC/MS and NMR. Biomed Chromatography. 27:148e155. 

  37. Torgerson JS, Hauptman J, Boldrin MN and Sjostrom L. (2004). XENical in the prevention of diabetes in obese subjects(XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. 27:155-161. 

  38. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW and Inoue K. (2004). P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 424:778-783. 

  39. Van der Wier B, Koek GH, Bast A and Haenen GRMM. (2015). The potential of flavonoids in the treatment of nonalcoholic fatty liver disease. Critical Reviews in Food Science and Nutrition. 57:834-855. 

  40. Wongs-Aree C, Giusti M and Schwartz S. (2006). Anthocyanins derived only from delphinidin in the blue petals of Clitoria ternatea. In Proceedings of the IV International Conference on Managing Quality in Chains-The Integrated View on Fruits and Vegetables Quality, Bangkok, Thailand. 30:437-442. 

  41. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ and Spiegelman BM. (1999). Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity. Molecular Cell. 3:151-158. 

  42. You Y, Yuan X, Lee HJ, Huang W, Jin W and Zhan J. (2015). Mulberry and mulberry wine extract increase the number of mitochondria during brown adipogenesis. Food and Function. 6:401-408. 

저자의 다른 논문 :

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로