[논문]암 환자의 마약성 진통제로 인한 변비 치료법에 대한 문헌고찰

윤지현; 김은혜; 이지영; 윤성우

doi:10.15432/jkto.2020.25.2.037

암 환자의 마약성 진통제로 인한 변비 치료법에 대한 문헌고찰
A Literature Review of Management for Opioid-Induced Constipation in Cancer Patients 원문보기

大韓癌韓醫學會誌 = Journal of Korean traditional oncology, v.25 no.2, 2020년, pp.37 - 49

윤지현 (강동경희대학교한방병원 한방암센터 한방내과) , 김은혜 (강동경희대학교한방병원 한방암센터 한방내과) , 이지영 (강동경희대학교한방병원 한방암센터 한방내과) , 윤성우 (강동경희대학교한방병원 한방암센터 한방내과)

Abstract ▼ AI-Helper

Objective: Constipation is the most common adverse effect of opioid analgesic therapy in cancer patients. This can be associated with physical and emotional distress to cancer patients. The purpose of this study is to review the standard and alternative interventions of the management for opioid-induced constipation (OIC). Methods: The studies were searched from databases, including Pubmed, Google scholar, KISS, NDSL, and OASIS. The main search terms included such as constipation, opioid, opioid-induced constipation, cancer, management, herb, and acupuncture. Results: The prevention and usual care of constipation is a key tool for the management of OIC. Also, prophylactic laxatives starting concurrently with opiates helped to prevent developing constipation. Peripherally acting μ-opioid receptor antagonists (PAMORAs) significantly reduced OIC and well-tolerated. In addition, acupuncture, herb medicines, and interferential current or transcutaneous electrical nerve stimulation to acupoints had effectiveness in reducing constipation. Conclusion: Preliminary data indicate that PAMORAs and Traditional Korean Medicine may be considered as the management of unresolved OIC. However, due to the limited articles, more systematic and rigorous clinical trials are needed.

주제어

표/그림 (2)

표 Table 1. Summary of PAMORAs for the management of OIC
표 Table 2. Summary of Traditional Korean Medicine for the management of OIC

참고문헌 (51)

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