최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기대한임상독성학회지 = Journal of the Korean society of clinical toxicology, v.20 no.2, 2022년, pp.39 - 44
정성필 (연세의대 응급의학교실) , 문정미 (전남의대 응급의학교실) , 전병조 (전남의대 응급의학교실)
N-Acetylcysteine (NAC) is the standard antidote treatment for preventing hepatotoxicity caused by acetaminophen (AAP) poisoning. This review summarizes the recent evidence for the treatment of AAP poisoning. Several alternative intravenous regimens of NAC have been suggested to improve patient safet...
Chung SP, Kim SH, Lee HS. Acetaminophen Poisoning. J?Korean Soc Clin Toxicol 2008;6:1-8.
Chun BJ, Moon JM, Kim SH. Antidote for acetaminophen?poisoning: N-acetylcysteine. J Korean Med Assoc 2013;56:1067-75.
Rumack BH, Bateman DN. Acetaminophen and acetylcysteine?dose and duration: past, present and future. Clin Toxicol (Phila)?2012;50:91-8.
Green JL, Heard KJ, Reynolds KM, Albert D. Oral and Intravenous?Acetylcysteine for Treatment of Acetaminophen Toxicity: A?Systematic Review and Meta-analysis. West J Emerg Med?2013;14:218-26.
Bourdeaux C, Bewley J. Death from paracetamol overdose despite?appropriate treatment with N-acetylcysteine. Emerg Med J?2007;24:e31.
Schwartz EA, Hayes BD, Sarmiento KF. Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. Ann?Emerg Med 2009;54:421-3.
Lucyk SN, Yarema MC, Sivilotti ML, Johnson DW, NettelAguirre A, Victorino C, et al. Outcomes of Patients With Premature?Discontinuation of the 21-h Intravenous N-Acetylcysteine?Protocol After Acute Acetaminophen Overdose. J Emerg Med?2016;50:629-37.
Wong A, Graudins A. Simplification of the standard three-bag?intravenous acetylcysteine regimen for paracetamol poisoning?results in a lower incidence of adverse drug reactions. Clin?Toxicol (Phila) 2016;54:115-9.
Chiew AL, Reith D, Pomerleau A, Wong A, Isoardi KZ,?Soderstrom J, et al. Updated guidelines for the management of?paracetamol poisoning in Australia and New Zealand. Med J?Aust 2020;212:175-83.
Pettie JM, Caparrotta TM, Hunter RW, Morrison EE, Wood DM,?Dargan PI, et al. Safety and Efficacy of the SNAP 12-hour?Acetylcysteine Regimen for the Treatment of Paracetamol?Overdose. EClinicalMedicine 2019;11:11-7.
Baumgartner K, Filip A, Liss D, Devgun J, Schwarz E, Mullins?M. N-acetylcysteine for acetaminophen toxicity: The one-bag?regimen. Br J Clin Pharmacol 2021;87:2399-400.
Marks DJB, Dargan PI, Archer JRH, et al. Outcomes from massive paracetamol overdose: a retrospective observational study.?Br J Clin Pharmacol 2017;83:1263-72.
Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Clin Toxicol?(Phila) 2019;57:686-91.
Chiew AL, Isbister GK, Kirby KA, et al. Massive paracetamol?overdose: an observational study on the effect of activated charcoal and increased acetylcysteine dose (ATOM 2). Clin Toxicol?2017;55:1055-65.
Sivilotti ML, Juurlink DN, Garland JS, Lenga I, Poley R, Hanly?LN, et al. Antidote removal during haemodialysis for massive?acetaminophen overdose. Clin Toxicol (Phila) 2013;51:855-63.
Wiegand TJ, Margaretten M, Olson KR. Massive acetaminophen?ingestion with early metabolic acidosis and coma: treatment with?IV NAC and continuous venovenous hemodiafiltration. Clin?Toxicol (Phila) 2010;48:156-9.
Fannin RD, Russo M, O'Connell TM, Gerrish K, Winnike JH,?Macdonald J, et al. Acetaminophen dosing of humans results?in blood transcriptome and metabolome changes consistent?with impaired oxidative phosphorylation. Hepatology 2010;51:227-36.
Prill S, Bavli D, Levy G, Ezra E, Schmalzlin E, Jaeger MS, et al.?Real-time monitoring of oxygen uptake in hepatic bioreactor?shows CYP450-independent mitochondrial toxicity of paracetamol and amiodarone. Arch Toxicol 2016; 90:1181-91.
Downs JW, Cumpston KL, Kershner EK, Troendle MM, Rose?SR, Wills BK. Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. Clin Toxicol?(Phila) 2021;59:932-6.
Edwards DA, Fish SF, Lamson MJ, et al. Prediction of acetaminophen level from clinical history of overdose using a pharmacokinetic model. Ann Emerg Med 1986;15:1314-9.
Chiew AL, Buckley NA. Acetaminophen Poisoning. Crit Care?Clin 2021;37:543-61.
Elms AR, Owen KP, Albertson TE, Sutter ME. Fatal myocardial?infarction associated with intravenous N-acetylcysteine error.?Int J Emerg Med 2011;4:54.
Bailey B, Blais R, Letarte A. Status epilepticus after a massive?intravenous N-acetylcysteine overdose leading to intracranial?hypertension and death. Ann Emerg Med 2004;44:401-6.
Lewis JC, Lim M, Lai L, Mendoza E, Albertson TE,?Chenoweth JA. Evaluation of N-acetylcysteine dose for the?treatment of massive acetaminophen ingestion. Clin Toxicol?(Phila) 2022;60:507-13.
Gosselin S, Juurlink DN, Kielstein JT, Ghannoum M, Lavergne?V, Nolin TD, et al. Extracorporeal treatment for acetaminophen?poisoning: recommendations from the EXTRIP workgroup. Clin?Toxicol (Phila) 2014;52:856-67.
Ali M, Misurati M, Rodgers R, Pooni J. Haemodiafiltration as?an effective treatment option for massive paracetamol overdose. BMJ Case Rep 2019;12:e228920.
Gaber M, Wong A, Koutsogiannis Z, Greene SL. Massive paracetamol overdose associated with mitochondrial dysfunction?and pancytopenia, without hepatotoxicity. Eur J Emerg Med?2016;23:460-2.
Wong A, Tong RLK, Ryan L, Crozier T, Graudins A. The use?of sustained low efficiency dialysis (SLED) in massive paracetamol overdose. Clin Toxicol (Phila) 2018;56:229-31.
Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity:?pathophysiology, clinical manifestations, and management. J?Med Toxicol 2008;4:2-6.
Filip AB, Berg SE, Mullins ME, Schwarz ES; Toxicology?Investigators Consortium (ToxIC). Fomepizole as an adjunctive?therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020.?Clin Toxicol (Phila) 2022:1-6.
Pourbagher-Shahri AM, Schimmel J, Shirazi FM, Nakhaee S,?Mehrpour O. Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. Toxicol Lett 2022;355:47-61.
Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez?FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J?Biol Chem 1996;271:12063-7.
Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke?H, Rumack BH, et al. The Effect of 4-Methylpyrazole on?Oxidative Metabolism of Acetaminophen in Human Volunteers.?J Med Toxicol 2020;16:169-76.
Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke?MW, Freudenthal BD, et al. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity?in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicol Sci?2019;170:57-68.
Schiodt FV, Ott P, Christensen E, Bondesen S. The value of?plasma acetaminophen half-life in antidote-treated acetaminophen overdosage. Clin Pharmacol Ther 2002;71:221-5.
Chiu MH, Jaworska N, Li NL, Yarema M. Massive Acetaminophen?Overdose Treated Successfully with N-Acetylcysteine, Fomepizole,?and Hemodialysis. Case Rep Crit Care 2021;2021:6695967.
Cuninghame S, Lotfy K, Cameron P. Massive acetaminophen?overdose with metabolic acidosis refractory to N-acetylcysteine,?fomepizole, and renal replacement therapy. Toxicol Rep 2021;8:804-7.
Ghannoum M, Kazim S, Grunbaum AM, Villeneuve E, Gosselin?S. Massive acetaminophen overdose: effect of hemodialysis on?acetaminophen and acetylcysteine kinetics. Clin Toxicol (Phila)?2016;54:519-22.
Kiernan EA, Fritzges JA, Henry KA, Katz KD. Case Rep Emerg?Med 2019;2019:9301432.
Woolum JA, Hays WB, Patel KH. Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose. Am J Emerg Med 2020;38:692.e5-692.e7.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.