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Journal of virology : JVI, v.95 no.11, 2021년, pp.e02477-20 - e02477-20
Zhang, Yufei (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , Huang, Kun (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , Wang, Ting (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , Deng, Fei (State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China) , Gong, Wenxiao (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , Hui, Xianfeng (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , Zhao, Ya (State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China) , He, Xinlin (State Key Laboratory of Agricultural Microbiolog) , Li, Chengfei , Zhang, Qiang , Chen, Xi , Lv, Changjie , Lin, Xian , Yang, Ying , Sun, Xiaomei , Shi, Zhengli , Chen, Huanchun , Zou, Zhong , Jin, Meilin
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Aged BALB/c mice are in use as a model of disease caused by SARS-CoV-2. Our research demonstrated SARS-CoV-2 can rapidly adapt in aged BALB/c mice through causing mutations at the RBD of the S protein.Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and mortality in ...
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