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大韓化粧品學會誌 = Journal of the society of cosmetic scientists of Korea, v.37 no.2, 2011년, pp.97 - 119
조완구 (전주대학교 대체의학대학 기초의과학과)
전 세계의 소비자들은 예전에 비해 외모, 건강 및 안락한 삶에 관심을 집중시키고 있다. 이와 같은 경향은 유효성분을 함유한 기능성화장품의 요구 또한 증대시키고 있다. 차별화된 제형을 이용한 감각적인 사용감이 구현된 처방은 실질적인 소비자 인지 수준의 화장품에 이용되고 있으며 그 결과로 화장품시장이 확대되고 있다. 이와 더불어 유효성분의 경피 전달을 통한 소비자 인지 수준의 제품을 개발하기 위해서 화장품 과학자는 첨단 의약품의 다양한 기술을 접목해야 한다. 다양한 경피 흡수 수단의 기술이 기능성 화장품에 사용되고 있다. 본 총설에서는 차세대 경피 전달 시스템으로서 큰 잠재력을 가진 경피 전달 시스템에 대해서 논하고자 한다.
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World consumers are now focusing on their health, well-being and appearance more than ever before. This trend is creating heightened demand for products formulated as cosmeceuticals with active ingredients. A significant number of innovative formulations are now being used in cosmetics with real con...
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 피부는 어떤 수단으로 사용될 수 있는가? | 피부는 인체에서 가장 넓은 기관으로 피하전달을 위한 경피 흡수 수단으로 사용될 수 있다. 경구 투여 시, 약효 발현과 함께 전신적 부작용이 일어날 수 있으며 피하주사의 경우는 일정 약물농도의 국소 적용이 힘들다. | |
| 경피흡수에서 몇 Da 이상의 물질은 피부 흡수가 불가능한가? | 지난 50년 동안, 계면 활성제, 지방산, 지방산 에스테르, 그리고 아존(azone)같은 화합물들이 제한된 가운데도 경피 흡수 증진을 위해서 사용되어 왔다[2]. 경피흡수에서 4500 Da 이상의 물질은 피부 흡수가 불가능하다. 최근 높은 처리량(high-throughput)의 스크리닝 방법 발전과 분자 설계 등의 방법을 이용하여 경피 흡수 촉진 제를 개발하고 있다[3]. | |
| 높은 처리량(high-throughput)의 스크리닝 방법 발전과 분자 설계 등의 방법을 이용한 경피 흡수 촉진 제의 예시는 무엇이 있는가? | 최근 높은 처리량(high-throughput)의 스크리닝 방법 발전과 분자 설계 등의 방법을 이용하여 경피 흡수 촉진 제를 개발하고 있다[3]. 그중 한 가지 예로서 Tat (tran-sactivator of transcription)를 부분적으로 활용한 시도 등이 진행되고 있다[4-6]. HIV-1에서 유래한 TAT (transactivating transcriptional activator) 단백질은 세포 내로의 침투가 용이한 것으로 보고되고 있으며 TAT 펩타이드를 유효한 단백질에 결합하여 단백질의 피부 침투를 연구하였다. |
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