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NTIS 바로가기약학회지 = Yakhak hoeji, v.60 no.3, 2016년, pp.118 - 127
하혜민 (인제대학교 약학대학) , 천부순 (인제대학교 약학대학)
A growing number of studies have demonstrated that ABCB1 gene polymorphisms are associated with the variability of responses to imatinib. However, the effects of ABCB1 polymorphisms on imatinib response in chronic myeloid leukemia (CML) are inconsistent. The aim of the present study was to clarify t...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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필라델피아 염색체는 어떻게 생성되는가? | 만성 골수성 백혈병은 조혈모세포의 이상으로 과립구 백혈구가 과도하게 증식하는 만성 골수증식성 암이다. 만성 골수성 백혈병 환자에서 발견되는 중요한 특징인 필라델피아 염색체(Philadelphia chromosome)는 9번 염색체의 ABL 유전자와 22번 염색체의 BCR 유전자의 상호전위에 의한 융합으로 생성된다. 이때 생성된 BCR-ABL 융합유전자에 의해 합성되는 발암단백질 P210 BCR-ABL은 강력한 티로신 키나아제(tyrosine kinase) 활성을 가지며 골수구 전구세포의 세포자멸사(apoptosis)를 억제하여 이 세포들의 비정상적인 증폭을 일으켜 결국 백혈병을 초래한다. | |
만성 골수성 백혈병의 급성기는 어떤 상태인가? | 만성 골수성 백혈병은 병기에 따라 급성기(blastic phase, BP), 가속기(accelerated phase, AP), 그리고 만성기(chronic phase, CP)로 나뉜다. 급성기는 말초혈액 혹은 골수에서 모세포(blasts)의 비율이 30%를 넘거나 간, 비장, 임파절을 제외한 골수 외에서 모세포의 침윤이 발견되는 상태이며 가속기는 다음의 기준 중 어느 하나에 속하는 경우에 해당된다: 말초혈액 또는 골수에서의 모세포 비율이 10~30%; 모세포와 전골수세포(promyelocytes)를 합하여 말초혈액 또는 골수에서의 비율이 30% 미만; 말초혈액의 호염기구(basophils) 비율이 20% 이상; 치료와 무관한 혈소판 감소증(<100×103/μl) 또는 치료에 반응하지 않는 혈소판 증가증(>1,000×103/μl); 비장 비대; 필라델피아 염색체 외의 염색체 이상; 지속적인 백혈구증가(>10×103/μl). 반면 골수 외에서 모세포의 침윤이 없이 말초혈액 혹은 골수에서 모세포가 15% 미만, 호염기구가 20% 미만, 모세포와 전골수세포를 합하여 30% 미만, 그리고 혈소판 수가 100×103/μl 이상인 경우는 만성기에 속한다. | |
만성 골수성 백혈병이란? | 만성 골수성 백혈병은 조혈모세포의 이상으로 과립구 백혈구가 과도하게 증식하는 만성 골수증식성 암이다. 만성 골수성 백혈병 환자에서 발견되는 중요한 특징인 필라델피아 염색체(Philadelphia chromosome)는 9번 염색체의 ABL 유전자와 22번 염색체의 BCR 유전자의 상호전위에 의한 융합으로 생성된다. |
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