[논문]항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석

김은혜; 윤지현; 이지영; 윤성우

doi:10.15432/jkto.2020.25.2.023

항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석
The Therapeutic Efficacy of Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis 원문보기

大韓癌韓醫學會誌 = Journal of Korean traditional oncology, v.25 no.2, 2020년, pp.23 - 36

김은혜 (강동경희대학교 한방암센터 한방내과) , 윤지현 (강동경희대학교 한방암센터 한방내과) , 이지영 (강동경희대학교 한방암센터 한방내과) , 윤성우 (강동경희대학교 한방암센터 한방내과)

Abstract ▼ AI-Helper

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

주제어

표/그림 (4)

그림 Figure 1. Flow diagram of study screening Abbreviations: RCT, randomized controlled trial.
표 Table 1. The characteristics of the included randomized controlled trials
그림 Figure 2. Risk of bias graph of the included randomized controlled trials. "+", low risk of bias; "?", unclear risk of bias; "-", high risk of bias.
그림 Figure 3. The therapeutic efficacy of herbal medicine in chemotherapy-induced peripheral neuropathy patients. (a) Oral administrated herbal medicine showed a significantly higher effective rate than usual care. (b) Topical herbal medicine showed an improved effective rate than placebo. (c) Also, the effective rate was higher in topical herbal medicine compared with usual care. Abbreviations: po, orally administrated; topical, topical herbal medicine

참고문헌 (35)

통계청. 2019년 사망원인통계. Available from: URL: http://kostat.go.kr
Fitzmaurice C, Allen, C, Barber RM, Barregard L, Bhutta ZA, Brenner H et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA oncology 2017;3(4):524-48.

상세보기
Yarbro CH, Wujcik D, Gobel BH. Cancer nursing: principles and practice. p. 1063. Jones & Bartlett Publishers. 2010.
Oh PJ, Kim YL. Effectiveness of non-pharmacologic interventions in chemotherapy induced peripheral neuropathy: a systematic review and meta-analysis. Journal of Korean Academy of Nursing 2018;48(2):123-42.

원문보기 상세보기
Armstrong T, Almadrones L, Gilbert MR. Chemotherapy-induced peripheral neuropathy. Oncology nursing forum 2005;32(3).
Richardson PG, Briemberg H, Jagannath S, Wen PY, Barlogie B, Berenson J et al. Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. Journal of clinical oncology 2006;24(19):3113-20.

상세보기
Windebank AJ, Grisold W. Chemotherapy induced neuropathy. Journal of the Peripheral Nervous System 2008;13(1):27-46.

상세보기
Tofthagen C, Visovsky C, Beckstead J, Loy I, Eckelman E. Results of a strength and balance training pilot study for colorectal cancer survivors with peripheral neuropathy caused by oxaliplatin. Rehabilitation Oncology 2014;32(4):38-44.

상세보기
Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update. Journal of Clinical Oncology 2020;38(28):3325-48.

상세보기
Fukuda Y, Li Y, Segal RA. A mechanistic understanding of axon degeneration in chemotherapy-induced peripheral neuropathy. Frontiers in neuroscience 2017;11:481.

상세보기
Wickham R. Chemotherapy-induced peripheral neuropathy: a review and implications for oncology nursing practice. Clinical journal of oncology nursing 2007;11(3):361.

상세보기
Smith EML, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. Jama 2013;309(13):1359-67.

상세보기
Tsai JC, Chung HH, Shang CC, YU YC, Fang YL. The effect of integrated TCM with chemotherapy on quality of life and TCM syndrome. Journal of Family Medicine and Disease Prevention 2017;3(49):1-8.
Wang Q, Jiao L, Wang S, Chen P, Bi L, Zhou D et al. Adjuvant Chemotherapy with Chinese Herbal Medicine Formulas Versus Placebo in Patients with Lung Adenocarcinoma after Radical Surgery: a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Biological Procedures Online 2020;22(1):1-10.

상세보기
Ohnishi S, Takeda H. Herbal medicines for the treatment of cancer chemotherapy-induced side effects. Frontiers in Pharmacology 2015:6(14):1-8.
Liu Y, May BH, Zhang AL, Guo X, Lu C, Xue CC et al. Integrative herbal medicine for chemotherapy-induced peripheral neuropathy and hand-foot syndrome in colorectal cancer: a systematic review and meta-analysis. Integrative cancer therapies 2019;18:1534735418817833.
Noh H, Yoon SW, Park B. A systematic review of herbal medicine for chemotherapy induced peripheral neuropathy. Evidence-Based Complementary and Alternative Medicine 2018;2018:6194184.

상세보기
Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ et al. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. Seoul: National Evidence-based Healthcare Collaborating Agency 2011;25.
김수영, 박지은, 서현주, 서혜선, 손희정, 신채민 외. NECA 체계적 문헌고찰 매뉴얼. p. 1-287. 서울. 한국보건의료연구원. 2011
Park JH, Lee JS, Cho CK, Yoo HS. Electroacupuncture for the treatment of the chemotherapy-induced peripheral neuropathy in breast cancer patient: a case report. Journal of Korean Traditional Oncology 2015;20(1):1-9.

원문보기 상세보기
戴惠. 中？熏洗治？紫杉醇化？致周？神？毒性的？床？究. 中？中？？？代？程？育 2017;15(24):96-8.
丁蓉, ？介格, 汪？. ？？四逆？防治？沙利？周？神？毒性的？床？察. 南京中？？大？？？ 2014;5:432-3.
焦蕉, ？路丹, 黎月恒, 李？芳, 唐？云. ？？和血通？方防治？沙利？化？后周？神？毒性？床？察. 云南中？中？？志 2019;(4):10.
李元？, ？？, 薛冬, 李占？, ？？琛, 王薇, 李萍萍. 中？治？化？所致周？神？病？的效果. 中？康？理？？？？ 2017;23(11):1321-5.
？彦？, 田？平, ？？, ？利, ？煌英, 朱世杰 et al. 中？外治化？性周？神？病？的多中心, ？机, ？盲, ？照？床？究. 中？中？？？志 2014;29(8):2682-5.
？？, ？？, ？仲珉, ？福？, ？？？, 崔佳 et al. ？？桂枝五物？熏洗用于化？后周？神？毒性的？床分析. ？？中？？志 2020;47(5):141-3.
王建楠, ？？, ？群浩, ？健？, ？？. 祛麻煎外用治？？沙利？相？外周神？毒性的？床？察. 中？中？？？志 2015;30(4):1347-9.
？邦翔. 益？活血方治？化？？致周？神？病？的效果分析. 中外？？？究 2018;(36):57.
？薇薇. 中？熏洗治？化？致周？神？毒性病？的？床？究. 湖南中？？大？？？ 2019;39(12): 1517-20.
Cavaletti G, Marmiroli P. Chemotherapy-induced peripheral neurotoxicity. Nature Reviews Neurology 2010;6(12):657.

상세보기
Wickham R. Review of a study of duloxetine for painful chemotherapy-induced peripheral neuropathy. Journal of the advanced practitioner in oncology 2013;4(5):361.

상세보기
Vickers AJ, Straus DJ, Fearon B, Cassileth BR. Acupuncture for postchemotherapy fatigue: a phase II study. Journal of clinical oncology 2004;22(9):1731-5.

상세보기
Ezzo J, Richardson MA, Vickers A, Allen C, Dibble S, Issell BF et al. Acupuncture point stimulation for chemotherapy induced nausea or vomiting. Cochrane database of systematic reviews 2006;2
Ben-Arye E, Shavit E, Wiental H, Schiff E, Agour O, Samuels N. Overcoming communication challenges in integrative supportive cancer care: The integrative physician, the psycho-oncologist, and the patient. Complementary therapies in medicine 2016;29:9-15.

상세보기
Cassileth BR, Deng GE, Gomez JE, Johnstone PA, Kumar N, Vickers AJ. Complementary therapies and integrative oncology in lung cancer: ACCP evidence-based clinical practice guidelines. Chest 2007;132(3):340S-354S.

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증