[논문]환경성질환과 환경유해인자의 연관성을 규명하기 위한 독성 연구 고찰

가유진; 지경희

doi:10.5668/jehs.2021.47.6.505

환경성질환과 환경유해인자의 연관성을 규명하기 위한 독성 연구 고찰
A Systematic Review of Toxicological Studies to Identify the Association between Environmental Diseases and Environmental Factors 원문보기

韓國環境保健學會誌 = Journal of environmental health sciences, v.47 no.6, 2021년, pp.505 - 512

가유진 (용인대학교 일반대학원 환경보건학과) , 지경희 (용인대학교 일반대학원 환경보건학과)

Abstract ▼ AI-Helper

Background: The occurrence of environmental disease is known to be associated with chronic exposure to toxic chemicals, including waterborne contaminants, air/indoor pollutants, asbestos, ingredients in humidifier disinfectants, etc. Objectives: In this study, we reviewed toxicological studies related to environmental disease as defined by the Environmental Health Act in Korea and toxic chemicals. We also suggested a direction for future toxicological research necessary for the prevention and management of environmental disease. Methods: Trends in previous studies related to environmental disease were investigated through PubMed and Web of Science. A detailed review was provided on toxicological studies related to the humidifier disinfectants. We identified adverse outcome pathways (AOPs) that can be linked to the induction of environmental diseases, and proposed a chemical screening system that uses AOP, chemical toxicity big data, and deep learning models to select chemicals that induce environmental disease. Results: Research on chemical toxicity is increasing every year, but there is a limitation to revealing a clear causal relationship between exposure to chemicals and the occurrence of environmental disease. It is necessary to develop various exposure- and effect-biomarkers related to disease occurrence and to conduct toxicokinetic studies. A novel chemical screening system that uses AOP and chemical toxicity big data could be useful for selecting chemicals that cause environmental diseases. Conclusions: From a toxicological point of view, developing AOP related to environmental diseases and a deep learning-based chemical screening system will contribute to the prevention of environmental diseases in advance.

주제어

참고문헌 (52)

Koh SB. Environmental diseases. J Korean Med Assoc. 2012; 55(3): 212-213.

상세보기
Korea Ministry of Government Legislation. Environmental Health Act. Available: https://www.law.go.kr/%EB%B2%95%EB%A0%B9/%ED%99%98%EA%B2%BD%EB%B3%B4%EA%B1%B4%EB%B2%95 [accessed 25 August 2021].
Pruss-ustun A, Corvalan C; World Health Organization. Preventing Disease through Healthy Environments: Towards an Estimate of the Environmental Burden of Disease. Geneva: World Health Organization; 2006.
National Institute of Environmental Health Sciences (NIEHS). Environmental Diseases from A to Z. Available: https://www.niehs.nih.gov/health/assets/docs_a_e/environmental_diseases_environmental_diseases_from_a_to_z_english_508.pdf [accessed 25 August 2021].
Zeliger HI. Causes, mechanisms and prevention of environmental diseases. Dual Diagn. 2015; 1(1): 1-18.
National Health Insurance Service (NHIS). "Allergic rhinitis" has the highest number of patients under the age of 10. Available: https://www.nhis.or.kr/nhis/together/wbhaea01600m01.do?modeview&articleNo136900&article.offset0&articleLimit10&srSearchVal%EC%B2%9C%EC%8B%9D [accessed 25 August 2021].
National Health Insurance Service (NHIS). Children with atopic dermatitis has a large number of patients in Jeju, and adults in Seoul, Gyeonggi, and Incheon. Available: https://www.nhis.or.kr/nhis/together/wbhaea01600m01.do?modeview&articleNo127650&article.offset0&articleLimit10&srSearchVal%EC%95%84%ED%86%A0%ED%94%BC [accessed 25 August 2021].
Kwon EJ. Analysis of treatment trends for asthma patients over the past 5 years. Policy Trends. 2019; 13(4): 56-65.
Jung KH. The policy direction on environment diseases and environmental risk of children health. Health Welf Forum. 2009; 152: 100-111.
Ministry of Environment. Systemic Response to Environmental Diseases such as Investigations on the Occurrence of Atopic Skin Diseases in Children. Available: http://www.me.go.kr/home/web/board/read.do?menuId10126&boardMasterId66&boardCategoryId&boardId145848 [accessed 25 August 2021].
Ministry of Environment. Status of Environmental Health Center ('21.09.06). Available: http://www.me.go.kr/home/web/policy_data/read.do?menuId10276&seq7347 [accessed 30 November 2021].
Korea Institute of S&T Evaluation and Planning (KISTEP). Core Technology Development Project for Prevention and Management of Environmental Disease. Available: https://scienceon.kisti.re.kr/commons/util/originalView.do?cnTRKO202000024358&dbtTRKO&rn [accessed 25 August 2021].
Ahn JJ. Asbestos and environmental disease. J Environ Health Sci. 2009; 35(6): 538-541.

원문보기 상세보기
Musk AW, de Klerk N, Reid A, Hui J, Franklin P, Brims F. Asbestosrelated diseases. Int J Tuberc Lung Dis. 2020; 24(6): 562-567.

상세보기
Park EK, Takahashi K, Jiang Y, Movahed M, Kameda T. Elimination of asbestos use and asbestos-related diseases: an unfinished story. Cancer Sci. 2012; 103(10): 1751-1755.

상세보기
Choi KY, Lee SM, Lee CM, Seo SC. Factor analysis of environmental disease by air pollution: analysis and implication of Google Trends data with big data. J Environ Health Sci. 2018; 44(6): 563-571.
Lam J, Koustas E, Sutton P, Padula AM, Cabana MD, Vesterinen H, et al. Exposure to formaldehyde and asthma outcomes: a systematic review, meta-analysis, and economic assessment. PLoS One. 2021; 16(3): e0248258.

상세보기
Jeong SH, Kim JH, Son BK, Hong SC, Kim SY, Lee GH, et al. Comparison of air pollution and the prevalence of allergy-related diseases in Incheon and Jeju City. Korean J Pediatr. 2011; 54(12): 501-506.

원문보기 상세보기
Kim J, Kim H, Lim D, Lee YK, Kim JH. Effects of indoor air pollutants on atopic dermatitis. Int J Environ Res Public Health. 2016; 13(12): 1220.

상세보기
Jeong MH, Kim HR, Park YJ, Chung KH. Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2. Toxicol Appl Pharmacol. 2019; 380: 114691.

상세보기
Jung HN, Zerin T, Podder B, Song HY, Kim YS. Cytotoxicity and gene expression profiling of polyhexamethylene guanidine hydrochloride in human alveolar A549 cells. Toxicol In Vitro. 2014; 28(4): 684-692.

상세보기
Kim HR, Hwang GW, Naganuma A, Chung KH. Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate. J Toxicol Sci. 2016; 41(6): 711-717.

상세보기
Kim HR, Lee K, Park CW, Song JA, Shin DY, Park YJ, et al. Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses. Arch Toxicol. 2016; 90(3): 617-632.

상세보기
Lee YH, Seo DS. Toxicity of humidifier disinfectant polyhexamethylene guanidine hydrochloride by two-week whole body-inhalation exposure in rats. J Toxicol Pathol. 2020; 33(4): 265-277.

상세보기
Lee YH, Seo DS, Lee MJ, Cha HG. Immunohistochemical characterization of oxidative stress in the lungs of rats exposed to the humidifier disinfectant polyhexamethylene guanidine hydrochloride. J Toxicol Pathol. 2019; 32(4): 311-317.

상세보기
Lee JD, Kim HY, Kang K, Jeong HG, Song MK, Tae IH, et al. Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats. Arch Toxicol. 2020; 94(3): 887-909.

상세보기
Lee J, Choi SJ, Jeong JS, Kim SY, Lee SH, Yang MJ, et al. A humidifier disinfectant biocide, polyhexamethylene guanidine phosphate, inhalation exposure during pregnancy induced toxicities in rats. J Hazard Mater. 2021; 404(Pt B): 124007.

상세보기
Nemery B, Hoet PH. Humidifier disinfectant-associated interstitial lung disease and the Ardystil syndrome. Am J Respir Crit Care Med. 2015; 191(1): 116-117.

상세보기
Park EJ, Park SJ, Kim S, Lee K, Chang J. Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution. Toxicol Lett. 2018; 286: 108-119.

상세보기
Park YJ, Jeong MH, Bang IJ, Kim HR, Chung KH. Guanidine-based disinfectants, polyhexamethylene guanidine-phosphate (PHMGP), polyhexamethylene biguanide (PHMB), and oligo(2-(2-ethoxy) ethoxyethyl guanidinium chloride (PGH) induced epithelial-mesenchymal transition in A549 alveolar epithelial cells. Inhal Toxicol. 2019; 31(4): 161-166.

상세보기
Park JS, Park YJ, Kim HR, Chung KH. Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells. J Toxicol Sci. 2019; 44(6): 415-424.

상세보기
Song JA, Park HJ, Yang MJ, Jung KJ, Yang HS, Song CW, et al. Polyhexamethyleneguanidine phosphate induces severe lung inflammation, fibrosis, and thymic atrophy. Food Chem Toxicol. 2014; 69: 267-275.

상세보기
Song J, Kim W, Kim YB, Kim B, Lee K. Time course of polyhexamethyleneguanidine phosphate-induced lung inflammation and fibrosis in mice. Toxicol Appl Pharmacol. 2018; 345: 94-102.

상세보기
Do VQ, Seo YS, Park JM, Yu J, Duong MTH, Nakai J, et al. A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn 2+ and generating reactive oxygen species. Arch Toxicol. 2021; 95(2): 541-556.

상세보기
Lee E, Son SK, Yoon J, Cho HJ, Yang SI, Jung S, et al. Two cases of chloromethylisothiazolinone and methylisothiazolinone-associated toxic lung injury. J Korean Med Sci. 2018; 33(16): e119.

상세보기
Park EJ, Seong E. Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells. Toxicol In Vitro. 2020; 62: 104661.

상세보기
Park EJ, Seong E, Kang MS, Lee GH, Kim DW, Han JS, et al. Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response. Toxicol Appl Pharmacol. 2020; 404: 115182.

상세보기
Choi HY, Lee YH, Lim CH, Kim YS, Lee IS, Jo JM, et al. Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats. Part Fibre Toxicol. 2020; 17(1): 5.

상세보기
Jeon H, Kim D, Yoo J, Kwon S. Effects of benzalkonium chloride on cell viability, inflammatory response, and oxidative stress of human alveolar epithelial cells cultured in a dynamic culture condition. Toxicol In Vitro. 2019; 59: 221-227.

상세보기
Baek W, Shim Y. A study on the improvement of health damage relief regulation due to environmental hazardous factors. J Environ Policy. 2013; 12(1): 75-100.

원문보기 상세보기
Klimisch HJ, Andreae M, Tillmann U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol. 1997; 25(1): 1-5.

상세보기
Lee J, Choi SJ, Jeong JS, Kim SY, Lee SJ, Baek SK, et al. Adverse postnatal developmental effects in offspring from humidifier disinfectant biocide inhaled pregnant rats. Chemosphere. 2022; 286(Pt 2): 131636.

상세보기
Song MK, Kim DI, Lee K. Time-course transcriptomic alterations reflect the pathophysiology of polyhexamethylene guanidine phosphate-induced lung injury in rats. Inhal Toxicol. 2019; 31(13-14): 457-467.

상세보기
Go HN, Lee SH, Cho HJ, Ahn JR, Kang MJ, Lee SY, et al. Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model. Sci Rep. 2020; 10(1): 4099.

상세보기
Pelletier G, Valli VE, Rigden M, Poon R. Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl4-isothiazolin-3-one biocide formulation in Sprague-Dawley rats. Drug Chem Toxicol. 2014; 37(2): 149-155.

상세보기
Park K. An analysis of a humidifier disinfectant case from a toxicological perspective. Environ Health Toxicol. 2016; 31: e2016013.

원문보기 상세보기
Perkins EJ, Ashauer R, Burgoon L, Conolly R, Landesmann B, Mackay C, et al. Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment. Environ Toxicol Chem. 2019; 38(9): 1850-1865.

상세보기
Leem JH, Chung KH. Combined approaches using adverse outcome pathways and big data to find potential diseases associated with humidifier disinfectant. Environ Health Toxicol. 2016; 32: e2017003.

상세보기
Jeong J, Garcia-Reyero N, Burgoon L, Perkins E, Park T, Kim C, et al. Development of adverse outcome pathway for PPARγ antagonism leading to pulmonary fibrosis and chemical selection for its validation: ToxCast database and a deep learning artificial neural network model-based approach. Chem Res Toxicol. 2019; 32(6): 1212-1222.

상세보기
Liu SS, Wang HY, Tang JM, Zhou XM. Hypoxia-induced collagen synthesis of human lung fibroblasts by activating the angiotensin system. Int J Mol Sci. 2013; 14(12): 24029-24045.

상세보기
United States Environmental Protection Agency. EPA is Moving Towards the Future of Chemical Assessments with New Approach Methods. Available: https://www.epa.gov/sciencematters/epa-moving-towards-future-chemical-assessments-new-approach-methods [accessed 25 August 2021].
Tang W, Chen J, Wang Z, Xie H, Hong H. Deep learning for predicting toxicity of chemicals: a mini review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2018; 36(4): 252-271.

상세보기

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증